Navigation Links
US Tox21 to begin screening 10,000 chemicals
Date:12/7/2011

A high-speed robotic screening system, aimed at protecting human health by improving how chemicals are tested in the United States, begins today to test 10,000 compounds for potential toxicity. The compounds cover a wide variety of classifications, and include consumer products, food additives, chemicals found in industrial processes, and human and veterinary drugs. A complete list of the compounds is publicly available at http://www.epa.gov/ncct/dsstox.

Testing this 10,000 compound library begins a new phase of an ongoing collaboration between the National Institutes of Health, the U.S. Environmental Protection Agency, and the U.S. Food and Drug Administration, referred to as Tox21. NIH partners include the National Toxicology Program (NTP), administered by the National Institute of Environmental Health Sciences (NIEHS), and the NIH Chemical Genomics Center (NCGC), part of the NIH Center for Translational Therapeutics (NCTT), housed at the National Human Genome Research Institute (NHGRI).

"There has never been a compound library like this before," said NIEHS/NTP Director Linda Birnbaum, Ph.D.

Birnbaum is especially excited that some of the compounds the NTP has brought forward for testing are mixtures of chemicals. "All of us are exposed to many different chemicals at the same time, not just one chemical at a time," she said. "These new technologies allow us to more rapidly advance our understanding of not only individual chemicals, but mixtures of chemicals as well."

A subset of the NTP portion of the 10,000 compound library will focus on pilot testing several formulations or mixtures of compounds, a priority area for NIEHS/NTP. The library constituents were selected after a thorough analysis of existing scientific studies, more than 200 public chemical databases, and chemical nominations received from internal and external partners. Each test compound will undergo a thorough chemical analysis to verify its identity and determine its purity, concentration, and stability.

The goal of the testing is to provide results that will be useful for evaluating if these chemicals have the potential to disrupt processes in the human body to an extent that leads to adverse health effects.

The compounds will be tested in the Tox21 robotic screening system at the NCGC in Rockville, Md. The Tox21 robot, unveiled earlier this year, was purchased with funds provided by the NTP as part of its contribution to the Tox21 partnership.

"The robot has undergone rigorous testing since it was installed and unveiled earlier this year. It's ready to start testing this large compound library," said NHGRI Director Eric Green, M.D., Ph.D. "This is a milestone for Tox21, because it will allow us to test chemicals at a rate previously impossible for anyone to do by hand."

The development of methods for evaluating chemical toxicity has the potential to revolutionize the assessment of new environmental chemicals and the development of new drugs for therapeutic use.

"We are happy to contribute NCGC's pharmaceutical collection of approximately 3,500 compounds of approved and investigational drugs as part of the Tox21 program," said NCTT Scientific Director Christopher Austin, M.D. "Drug toxicity is one of the primary reasons that the development of new drugs fails and approved drugs are removed from the market, and the ability to better predict toxicity would improve the efficiency of drug development enormously."

The EPA seeks to understand the molecular basis of such chemicals to better protect human health and that of the environment.

"The Tox21 partnership integrates revolutionary advances in molecular biology, chemistry, and computer science, to quickly and cost-effectively screen the thousands of chemicals in use today," said Paul Anastas, Ph.D., assistant administrator of the EPA Office of Research and Development. "The innovative robotics screening technology will generate chemical toxicity data that EPA has never had before."

The FDA, also a partner in Tox21, emphasizes the value of this effort for the public. "The Tox21 rapid assessment of drug toxicity can become a powerful safety tool for protecting the American public. It also has the potential to help bring innovative drugs to market by allowing drug developers to identify unsafe candidate drugs early," said Janet Woodcock, M.D., director of the FDA Center for Drug Evaluation and Research.


'/>"/>
Contact: Robin Mackar
rmackar@niehs.nih.gov
919-541-0073
NIH/National Institute of Environmental Health Sciences
Source:Eurekalert

Related biology news :

1. Sentara begins international trial -- open at only 24 US locations
2. The Marine Mammal Center begins new leptospirosis study in California
3. Methane gas levels begin to increase again
4. Marine scientists to assess environment before offshore drilling begins in US arctic waters
5. Worlds top minds to celebrate the birth and life of beginnings
6. Is this the beginning of the end of plant breeding?
7. Brain-computer interface, developed at Brown, begins new clinical trial
8. UC Davis begins $2.8 million in studies of agricultural nitrogens impacts
9. Global curbs on overfishing are beginning to work
10. The ends of mRNAs may prevent the beginnings of cancer
11. Scientists begin to untangle root cause of Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2017)... , May 16, 2017   Bridge Patient ... organizations, and MD EMR Systems , an ... partner for GE, have established a partnership to ... product and the GE Centricity™ products, including Centricity ... These new integrations will allow ...
(Date:4/24/2017)... 2017 Janice Kephart , former ... Strategy Partners, LLP (IdSP) , today issues the ... Trump,s March 6, 2017 Executive Order: Protecting ... can be instilled with greater confidence, enabling the ... refugee applications are suspended by until at least ...
(Date:4/18/2017)... 2017  Socionext Inc., a global expert in SoC-based imaging and ... the M820, which features the company,s hybrid codec technology. A demonstration ... Probe, Inc., will be showcased during the upcoming Medtec Japan at ... the Las Vegas Convention Center April 24-27. ... Click here for an ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... first-ever genomics analysis platform specifically designed for life science researchers to analyze ... pioneering researcher Rosalind Franklin, who made a major contribution to the discovery ...
(Date:10/11/2017)... ... October 11, 2017 , ... The ... context, enabling overexpression experiments and avoiding the use of exogenous expression plasmids. The ... transformative for performing systematic gain-of-function studies. , This complement to loss-of-function studies, ...
(Date:10/11/2017)... Alto, CA, USA (PRWEB) , ... October 11, 2017 , ... ... set to take place on 7th and 8th June 2018 in San Francisco, CA. ... policy influencers as well as several distinguished CEOs, board directors and government officials from ...
(Date:10/11/2017)... , Oct. 11, 2017  VMS BioMarketing, a leading provider ... nationwide oncology Clinical Nurse Educator (CNE) network, which will launch ... for communication among health care professionals to enhance the patient ... office staff, and other health care professionals to help women ... cancer. ...
Breaking Biology Technology: