Navigation Links
UR study reveals chemo's toxicity to brain, possible treatment
Date:12/17/2009

Researchers have developed a novel animal model showing that four commonly used chemotherapy drugs disrupt the birth of new brain cells, and that the condition could be partially reversed with the growth factor IGF-1.

Published early online in the journal Cancer Investigation, the University of Rochester Medical Center study is relevant to the legions of cancer survivors who experience a frustrating decline in cognitive function after chemotherapy treatment, known as chemo-brain.

"It is not yet clear how our results can be generally applied to humans but we have taken a very significant step toward reproducing a debilitating condition and finding ways to treat it," said Robert Gross, M.D., Ph.D., professor of Neurology and of Pharmacology and Physiology at URMC and principal investigator of the study.

Chemo-brain is a newly recognized condition. The URMC team found surprising data about how the four drugs impact the brain, Gross said, and they are the first to report that the experimental insulin-like growth factor, IGF-1, may be beneficial.

The study was funded by a Department of Defense grant to Gross and by the National Cancer Institute to co-investigator and lead author, Michelle Janelsins, Ph.D., research assistant professor of Radiation Oncology at the James P. Wilmot Cancer Center.

More than 11 million Americans are living today after receiving a cancer diagnosis. Many of them have endured chemotherapy and although the side effects during treatment are well known, the lingering neurological effects are more puzzling. Patients often report memory lapses, trouble concentrating, confusion, difficulty multi-tasking and slow thinking for weeks, months or years after treatment ends.

The URMC team hypothesized that cognitive problems might stem from chemo destroying the ability of brain cells to regenerate in the hippocampus, which is primarily involved in memory formation and mood. They sought a
'/>"/>

Contact: Leslie Orr and Leslie White
Leslie_Orr@urmc.rochester.edu
585-275-5774
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Study shows loss of 15-42 percent of mammals in North America
2. UA-led study grapples with health effects of low-intensity warfare
3. Killer catfish? Venomous species surprisingly common, study finds
4. Berkeley Lab researchers participate in Homeland Security study of subway airflow
5. Study reveals H1N1 unexpected weakness
6. Tropical birds waited for land crossing between North and South America: UBC study
7. Studying hair of ancient Peruvians answers questions about stress
8. Study confirms association between tobacco smoke and behavioral problems in children
9. Study reveals how Arctic food webs affect mercury in polar bears
10. Study finds new relationship between gene duplication and alternative splicing in plants
11. Spices halt growth of breast stem cells, U-M study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... in about one per eight hundred births, Down syndrome ... genetic cause of intellectual disability. It results from a ... third copy of chromosome 21 (1% of the human ... team in the Department of Genetic Medicine and Development ... published in Nature , shed light on how ...
(Date:4/17/2014)... Clemson professor Rajendra Singh Thursday as a "Champion ... expand solar deployment in the residential, commercial and ... Professor of Electrical and Computer Engineering and director ... a local hero leading the charge across the ... solar power and driving policy changes at the ...
(Date:4/17/2014)... channels are implicated in many serious conditions such as ... potential target for drug therapies. Unfortunately, there is still ... Cambridge research provides fresh and unexpected insight into the ... components - β-subunit molecules - which are responsible for ... published in the most recent edition of the ...
Breaking Biology News(10 mins):Trisomy 21: How an extra little chromosome throws the entire genome off balance 2Trisomy 21: How an extra little chromosome throws the entire genome off balance 3White House honors Clemson professor as 'Champion of Change' for solar deployment 2Structure of sodium channels different than previously believed 2
... with the fact that the American bison, or buffalo, is ... love them as an important symbol of their countryand as ... found in a public survey released today by the Wildlife ... populations in the North America. The survey is part ...
... COLLEGE STATION, Nov. 18, 2008 A team led ... group of primates not seen alive in 85 years. ... of a small mouse and weighing less than 2 ... collected for a museum in 1921. Several scientists believed ...
... crucial role in sustaining the biodiversity of Europe,s ... workshop organised by the European Science Foundation (ESF). ... rivers against a combined onslaught from human development ... ecosystems and changing both the physical and biological ...
Cached Biology News:New national survey says public reveres bison 2New national survey says public reveres bison 3Texas A&M anthropologist discovers long-lost primate in Indonesia 2Alpine rivers hold important clues for preserving biodiversity and coping with climate change 2Alpine rivers hold important clues for preserving biodiversity and coping with climate change 3
(Date:1/14/2014)... WASHINGTON , Jan. 14, 2014  3D Communications, a leading provider ... scientific, regulatory, business, and media events in the United ... its former associate Virginia Cox , JD, is returning to ... Virginia Cox re-joins 3D after more than two years ...
(Date:1/14/2014)... , Jan. 14, 2014 The largest international ... medicinal plants and therapeutic derivatives thereof has endorsed ... and researchers about the challenges of adulterated herb ... ) The Society for Medicinal ...
(Date:1/14/2014)... Canada (PRWEB) January 14, 2014 In ... its motives and methods in product development and promotion ... the industry. This mistrust, fueled by concerns about the ... fed by reports of spectacular fines to the world’s ...
(Date:1/14/2014)... ®, provider of RapidResponse ®, a cloud-based supply chain ... S&OP ) service, is proud to be a gold sponsor ... at the Hilton San Diego Bayfront, January 30 – 31, ... , Director of Supply Chain at Amgen, as she presents ...
Breaking Biology Technology:Former FDA Associate Commissioner Returns To 3D Communications 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2
... Bok appointed Senior Director, Commercial Development;Sam Zeller appointed Senior ... LEXINGTON, Mass., Dec. 17 Microbia Precision Engineering, ... senior management team and bioproduct commercialization capabilities with the ... Development and Sam Zeller as Senior Director of Regulatory ...
... , , Acquisition will expand Abbott,s ... , CARLSBAD, Calif. and ABBOTT PARK, Ill., Dec. 17 ... (NYSE: ABT ) announced today that Abbott has exercised ... Inc., an Isis subsidiary, for a closing purchase price of $175 ...
... Trusted LASIK Surgeons launched its revolutionary Trusted LASIK Surgeons ... order to provide a resource for consumers seeking to ... directory apart is a unique screening process ensuring that ... eye surgery and laser eye surgery in the United ...
Cached Biology Technology:Microbia PE Bolsters Senior Management Team; Positions Company for Commercializing Proprietary Bioproducts 2Microbia PE Bolsters Senior Management Team; Positions Company for Commercializing Proprietary Bioproducts 3Abbott Exercises Its Option to Acquire Ibis Biosciences, a Subsidiary of Isis 2Abbott Exercises Its Option to Acquire Ibis Biosciences, a Subsidiary of Isis 3Abbott Exercises Its Option to Acquire Ibis Biosciences, a Subsidiary of Isis 4Abbott Exercises Its Option to Acquire Ibis Biosciences, a Subsidiary of Isis 5Hawaii LASIK Eye Surgery Expert Dr. John D. Olkowski Qualifies and Lists with Trusted LASIK Surgeons 2Hawaii LASIK Eye Surgery Expert Dr. John D. Olkowski Qualifies and Lists with Trusted LASIK Surgeons 3Hawaii LASIK Eye Surgery Expert Dr. John D. Olkowski Qualifies and Lists with Trusted LASIK Surgeons 4Hawaii LASIK Eye Surgery Expert Dr. John D. Olkowski Qualifies and Lists with Trusted LASIK Surgeons 5Hawaii LASIK Eye Surgery Expert Dr. John D. Olkowski Qualifies and Lists with Trusted LASIK Surgeons 6Hawaii LASIK Eye Surgery Expert Dr. John D. Olkowski Qualifies and Lists with Trusted LASIK Surgeons 7
... GELase™ Agarose Gel-Digesting Preparation contains a ... for simple, quantitative recovery of intact DNA ... agarose gels following electrophoresis in TAE, TBE, ... be digested directly in the TAE, TBE, ...
... in-house demand is causing shortages in your laboratory ... can cause unwanted distractions, problems and delays. ... hard work and endeavour! Bring us your idea ... it internationally. We work under ISO 9001 quality ...
... demand is causing shortages in your laboratory ... This can cause unwanted distractions, problems and ... for your hard work and endeavour! Bring ... it up and market it internationally. We ...
... demand is causing shortages in your laboratory or ... cause unwanted distractions, problems and delays. ... work and endeavour! Bring us your idea and ... internationally. We work under ISO 9001 quality assurance ...
Biology Products: