Navigation Links
UR study reveals chemo's toxicity to brain, possible treatment
Date:12/17/2009

Researchers have developed a novel animal model showing that four commonly used chemotherapy drugs disrupt the birth of new brain cells, and that the condition could be partially reversed with the growth factor IGF-1.

Published early online in the journal Cancer Investigation, the University of Rochester Medical Center study is relevant to the legions of cancer survivors who experience a frustrating decline in cognitive function after chemotherapy treatment, known as chemo-brain.

"It is not yet clear how our results can be generally applied to humans but we have taken a very significant step toward reproducing a debilitating condition and finding ways to treat it," said Robert Gross, M.D., Ph.D., professor of Neurology and of Pharmacology and Physiology at URMC and principal investigator of the study.

Chemo-brain is a newly recognized condition. The URMC team found surprising data about how the four drugs impact the brain, Gross said, and they are the first to report that the experimental insulin-like growth factor, IGF-1, may be beneficial.

The study was funded by a Department of Defense grant to Gross and by the National Cancer Institute to co-investigator and lead author, Michelle Janelsins, Ph.D., research assistant professor of Radiation Oncology at the James P. Wilmot Cancer Center.

More than 11 million Americans are living today after receiving a cancer diagnosis. Many of them have endured chemotherapy and although the side effects during treatment are well known, the lingering neurological effects are more puzzling. Patients often report memory lapses, trouble concentrating, confusion, difficulty multi-tasking and slow thinking for weeks, months or years after treatment ends.

The URMC team hypothesized that cognitive problems might stem from chemo destroying the ability of brain cells to regenerate in the hippocampus, which is primarily involved in memory formation and mood. They sought a
'/>"/>

Contact: Leslie Orr and Leslie White
Leslie_Orr@urmc.rochester.edu
585-275-5774
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Study shows loss of 15-42 percent of mammals in North America
2. UA-led study grapples with health effects of low-intensity warfare
3. Killer catfish? Venomous species surprisingly common, study finds
4. Berkeley Lab researchers participate in Homeland Security study of subway airflow
5. Study reveals H1N1 unexpected weakness
6. Tropical birds waited for land crossing between North and South America: UBC study
7. Studying hair of ancient Peruvians answers questions about stress
8. Study confirms association between tobacco smoke and behavioral problems in children
9. Study reveals how Arctic food webs affect mercury in polar bears
10. Study finds new relationship between gene duplication and alternative splicing in plants
11. Spices halt growth of breast stem cells, U-M study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2015)... 9, 2015  Unchained Labs just can,t get ... of Avid Nano. Avid Nano designs, develops and ... Also today, Unchained Labs UNcaged ... to use protein sizing system. The pUNk is ... hydrodynamic size, size distribution, aggregation population and molecular ...
(Date:7/8/2015)... NEW YORK , July 8, 2015 ... today announced BD & Guidepoint Mentor, ... free access to Guidepoint,s expert network services. ... developing cutting-edge technologies to improve healthcare delivery and outcomes ... manager, each start-up entrepreneur will be able to directly ...
(Date:7/7/2015)... Research and Markets ... the "Capacitive Fingerprint Sensors Patent Landscape" ... date, fingerprint sensing technology is the most reliable ... well developed. This patent landscape focuses on fingerprint ... domain of capacitive fingerprint sensors is closely linked ...
Breaking Biology News(10 mins):Unchained Labs just can't get enough, acquires Avid Nano, rocks out the new pUNk! 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 3Worldwide Capacitive Fingerprint Sensors Patent Landscape Market Report 2015-2020 - Main IP Holders include Seiko Epson, AuthenTec, Sony and STMicroelectronics 2
... 23, 2009) Actor and pancreatic cancer patient Patrick ... his compromised immune system underscores the sensitivity of the ... disease, rather than the disease itself. Lungs are ... open wound. Consequently, the body has developed an elaborate ...
... Regional warming and drought stress are the "dominant contributors" ... forests across the West during the past 50 years, a ... of all areas studied. The findings, to be published ... persistent increase in the mortality rate would ultimately cause a ...
... researchers have discovered there are differing taste pathways for ... smoking-cessation products. "We learned some of nicotine,s ... of the Duke Department of Neurobiology. "This is the ... activated by nicotine, and how these pathways are integrated ...
Cached Biology News:Research elucidates way lungs fight bacteria and prevent infection 2Warmer climate causing huge increase in tree mortality across the West 2Warmer climate causing huge increase in tree mortality across the West 3Nicotine activates more than just the brain's pleasure pathways 2
(Date:7/30/2015)... Grenoble, France and Dallas, TX, USA (PRWEB) , ... ... ... manufacturer of innovative nano and microsystems, has appointed Francois Vieillard as Sales & ... & Marketing at executive positions, Francois Vieillard will be responsible for reinforcing Tronics’ ...
(Date:7/30/2015)...   Senomyx , Inc. (NASDAQ: SNMX ), ... discover, develop, and commercialize novel flavor ingredients for the ... results for the second quarter 2015. ... on track to achieve our commercial and financial goals," ... the Company. "Since our last quarterly earnings report, our ...
(Date:7/30/2015)... ... July 30, 2015 , ... As part of its 2015 growth plan and as a follow ... service business units, Whitehouse Laboratories is pleased to announce that it has begun construction ... Center of Excellence and will be strictly dedicated to basic USP 51, USP 61, and ...
(Date:7/29/2015)... 29, 2015 US-Australian drug discovery company, Novogen ... it is committed to progressing its ground-breaking technology platforms ... and to ensure the Company delivers the best value ... Iain Ross , said the Company currently had an ... programs, discovery programs and academic partnerships and initiatives, and ...
Breaking Biology Technology:Tronics appoints Francois Vieillard as Sales and Marketing Director 2SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 2SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 3SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 4SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 5SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 6SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 7SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 8SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 9Whitehouse Labs Formally Announces Plans to Open a Microbiological Laboratory 2Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 2Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 3Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 4Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 5Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 6Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 7Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 8Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 9Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 10
... for applications from microelectronics to power lines because of ... could stop those electrons in their tracks? Rice ... the Aharonov-Bohm effect -- the interaction between electrically charged ... to carbon nanotubes. While doing so, they came ...
... ... fundraising campaign for spinal muscular atrophy gene therapy. , ... (PRWEB) July 8, 2010 -- Richmond-based FightSMA ... FightSMA is collaborating with the Santa Barbara –based Gwendolyn Strong Foundation , ...
... July 8 Bion Environmental Technologies, Inc. (OTC Bulletin ... forum on July 14 , hosted by SUNY ... Campus Center auditorium.  The forum, sought by Bion along with ... address Bion,s proposed beef cattle production facility that would be ...
Cached Biology Technology:Magnets trump metallics 2FightSMA Launches Gene Therapy Fundraising Campaign: “Realizing the Dream” 2FightSMA Launches Gene Therapy Fundraising Campaign: “Realizing the Dream” 3FightSMA Launches Gene Therapy Fundraising Campaign: “Realizing the Dream” 4Bion Confirms Participation in SUNY Oswego's Forum 2Bion Confirms Participation in SUNY Oswego's Forum 3Bion Confirms Participation in SUNY Oswego's Forum 4
ABCA1 Immunogen: Mouse ABCA1-expressing HeLa stable transfectants. Storage: -20 C, Avoid Freeze/Thaw Cycles...
... Rabbit polyclonal to ADAMTS16 ( ... Antigen: Synthetic ... of human ADAMTS-16. Note: the amino ... Entrez GeneID: 170690 ...
Goat polyclonal to SART3 ( Abpromise for all tested applications). Antigen: Synthetic peptide: MSNADFAKLFLRK, corresponding to C terminal amino acids 951-963 of Human SART3 Entrez Gene ID: 9...
JAB1 Immunogen: Synthetic peptide, conjugated to KLH, corresponding to residues S(201) E Y Q T I P L N K I E D F G V(216) of human JAB1. The sequence is identical in mouse and rat. Storage: -...
Biology Products: