Navigation Links
UQ research targets West Nile virus and dengue fever

Research conducted at The University of Queensland could contribute to the development of a vaccine and cure for West Nile virus and Dengue fever.

Led by Associate Professor Alexander Khromykh, a team of researchers from UQ's School of Molecular and Microbial Sciences identified a novel characteristic of the virus family to which these diseases belong.

The team found all flaviviruses produced a small molecule which, among other functions, controlled the host's response to viral infection.

This molecule, called a subgenomic noncoding ribonucleic acid (sfRNA), is a part of the virus genome.

"To develop new and effective antiviral strategies, we have to know as much as possible about the virus, or virus family, that we are fighting," Dr Khromykh said.

"As sfRNA is produced by all flaviviruses we tested so far, targeting it with an antiviral therapy may be effective for the whole range of flaviviruses.

"By using reverse genetic engineering we were able to generate viruses that do not produce this sfRNA and showed that these engineered viruses are no longer able to kill their hosts or elicit disease symptoms.

"These engineered viruses offer great potential as vaccine candidates as they are expected to elicit an antiviral immune response similar to the normal virus infection without causing a disease."

Dr Khromykh said by studying mice infected with these engineered West Nile viruses, the team learned more about how the body attempted to combat a flavivirus infection.

The part of the virus the infected cells in the body are unsuccessful in destroying forms the sfRNA, which helps the virus to kill cells and cause potentially deadly diseases, he said.

"We identified sfRNA as a potential antiviral target for the large group of medically important viruses," Dr Khromykh said.

"Moreover, the knowledge obtained from our studies with West Nile virus should be readily

Contact: Penny Robinson
Research Australia

Page: 1 2

Related biology news :

1. CSHL researchers map changing epigenetic modifications that enable transposons to run amok
2. New research shows how gene function drives natural selection in important class of genetic elements
3. UNH researchers track lobster migrations to improve population estimates
4. Siblings of mentally disabled face own lifelong challenges, according to researchers
5. Caltech researchers get first look at how groups of cells coordinate their movements
6. Computation and genomics data drive bacterial research into new golden age
7. Leeds research points to new therapy for hepatitis C treatment
8. Properties of unusual virus revealed in research
9. U of Minnesota researcher finds link between aggression, status and sex
10. Researchers study virus with unusual properties
11. Dune and dirty: Hurricane teaches lessons through ecosystem research
Post Your Comments:
(Date:4/2/2015)... , April 2, 2015 Fingerprint ... fingerprint sensor FPC1025 from the distributor World Peace Industrial ... during Q2 2015 although the major part of the ... will be used by smartphone manufacturers in ... is included in the communicated revenue guidance of + ...
(Date:3/30/2015)... 2015 Research and Markets ( ... Gesture Recognition Market in Automotive Sector 2014-2018" report ... Global Gesture Recognition market in Automotive Sector to grow ... Gesture recognition is the ability of a ... an individual. Gesture recognition technology can be 2D-based or ...
(Date:3/24/2015)... Fla. , March 24, 2015   ... management solutions, today announced that its U.are.U ® ... accessory retailer Goorin Bros . to achieve ... biometrics-based solution secures access to the POS terminal, ... increased risk of data breaches. ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2Global Gesture Recognition Market in Automotive Sector Report 2015 - Growing Number of Partnerships 2Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2
... a $3 million five-year contract to Biomark Inc., of ... equipment to conduct on-going fish studies throughout the 17 ... endangered fish recovery programs. "This contract provides ... behavior that we rely upon to inform our river ...
... at the recent United Nations meeting emphasized nutrition as ... of State Hillary Clinton said a key focus is ... of Missouri nutrition experts say getting back to basics ... families and communities in many ways. As ...
... University,s Courant Institute of Mathematical Sciences, was today named ... highest honor bestowed by the United States government on ... of this year,s National Medal of Science will receive ... year. Varadhan, who has been recognized for his ...
Cached Biology News:Contract awarded for equipment to support on-going fish studies in the West 2Eating balanced meals, farm-fresh produce benefits families, communities, nutrition researchers say 2NYU mathematician Varadhan named recipient of National Medal of Science 2
(Date:4/16/2015)... OncoTAb, Inc., a University ... company, announced today the appointment of physician and ... Operating Officer (COO). Cooper brings to OncoTAb more ... diagnostic and biotechnology platforms in the fields of ... career transcends the field of medical and scientific ...
(Date:4/16/2015)... Mass. , April 16, 2015  In recognition of ... collaborated with hemophilia advocacy groups to illuminate more than 15 ... , including Boston,s Zakim Bridge and ... New Orleans, Mercedes-Benz Superdome and ... occur during the evening of April 17, and coincide with ...
(Date:4/16/2015)... 2015  RegeneRx Biopharmaceuticals, Inc. (OTCQB: RGRX) ("the ... venture with G-treeBNT (ReGenTree LLC) has retained Ora, ... for the orphan disorder, neurotrophic keratopathy (NK), and ... syndrome (DES) in the U.S.  Both trials will ... year.  Each of these eye disorders was being ...
(Date:4/16/2015)... 16, 2015 ChemRar ... investment and R&D group, and Lancet, Russian ... development and commercialization of new medicines in ... intention to stimulate the innovative development of ... (Logo: ,     (Logo: , ...
Breaking Biology Technology:OncoTAb Names Dr. David L. Cooper as COO 2Biogen Shines A Light On Hemophilia Community By Illuminating U.S. Landmarks Red On World Hemophlia Day 2Biogen Shines A Light On Hemophilia Community By Illuminating U.S. Landmarks Red On World Hemophlia Day 3Biogen Shines A Light On Hemophilia Community By Illuminating U.S. Landmarks Red On World Hemophlia Day 4RegeneRx JV Retains Ora, Inc. to Conduct Phase 3 Trial for NK and Phase 2b/3 Trial for Dry Eye Syndrome in U.S. 2RegeneRx JV Retains Ora, Inc. to Conduct Phase 3 Trial for NK and Phase 2b/3 Trial for Dry Eye Syndrome in U.S. 3RegeneRx JV Retains Ora, Inc. to Conduct Phase 3 Trial for NK and Phase 2b/3 Trial for Dry Eye Syndrome in U.S. 4RegeneRx JV Retains Ora, Inc. to Conduct Phase 3 Trial for NK and Phase 2b/3 Trial for Dry Eye Syndrome in U.S. 5Lancet and ChemRar High Tech Center Have Announced a Partnership in the Development and Production of Novel Drugs in Russia 2
... because they either dont understand it or they dont feel ... the value of networking and when they should network. , ... arises (such as a new job or a product to ... is a process over time. If done effectively, their needs ...
... EAU CLAIRE -- In the latest of a string of ... has announced a fiber-optic gigabit Ethernet adapter compatible with Mac ... Adapters with Small Tree's OS X drivers means Apple-based ... can now take advantage of optical fiber's greater range than ...
... , a company specializing in patient-specific molecular data ... its president and chief executive officer, it announced ... and CEO of Pel-Freez Clinical Systems , ... biology and serologic products for solid organ and ...
Cached Biology Technology:Dispelling the top five myths about attending networking events 2Dispelling the top five myths about attending networking events 3Dispelling the top five myths about attending networking events 4
Request Info...
384 Cluster Tube Racks...
The antibody recognizes the peptide sequence ESESQGPK (aa 441-448) of human class III beta-tubulin specific for neurones....
... Immunogen: Partially purified chicken ... detects vitamin D receptor (VDR) from ... and fish tissues. This antibody ... glucocorticoid receptors. MA1-710 detects both ...
Biology Products: