Navigation Links
UQ research targets West Nile virus and dengue fever
Date:12/11/2008

Research conducted at The University of Queensland could contribute to the development of a vaccine and cure for West Nile virus and Dengue fever.

Led by Associate Professor Alexander Khromykh, a team of researchers from UQ's School of Molecular and Microbial Sciences identified a novel characteristic of the virus family to which these diseases belong.

The team found all flaviviruses produced a small molecule which, among other functions, controlled the host's response to viral infection.

This molecule, called a subgenomic noncoding ribonucleic acid (sfRNA), is a part of the virus genome.

"To develop new and effective antiviral strategies, we have to know as much as possible about the virus, or virus family, that we are fighting," Dr Khromykh said.

"As sfRNA is produced by all flaviviruses we tested so far, targeting it with an antiviral therapy may be effective for the whole range of flaviviruses.

"By using reverse genetic engineering we were able to generate viruses that do not produce this sfRNA and showed that these engineered viruses are no longer able to kill their hosts or elicit disease symptoms.

"These engineered viruses offer great potential as vaccine candidates as they are expected to elicit an antiviral immune response similar to the normal virus infection without causing a disease."

Dr Khromykh said by studying mice infected with these engineered West Nile viruses, the team learned more about how the body attempted to combat a flavivirus infection.

The part of the virus the infected cells in the body are unsuccessful in destroying forms the sfRNA, which helps the virus to kill cells and cause potentially deadly diseases, he said.

"We identified sfRNA as a potential antiviral target for the large group of medically important viruses," Dr Khromykh said.

"Moreover, the knowledge obtained from our studies with West Nile virus should be readily applicable for designing anti-viral drugs and engineering similar vaccine candidates for other medically important flaviviruses."


'/>"/>

Contact: Penny Robinson
penny.robinson@uq.edu.au
61-733-659-723
Research Australia
Source:Eurekalert

Related biology news :

1. CSHL researchers map changing epigenetic modifications that enable transposons to run amok
2. New research shows how gene function drives natural selection in important class of genetic elements
3. UNH researchers track lobster migrations to improve population estimates
4. Siblings of mentally disabled face own lifelong challenges, according to researchers
5. Caltech researchers get first look at how groups of cells coordinate their movements
6. Computation and genomics data drive bacterial research into new golden age
7. Leeds research points to new therapy for hepatitis C treatment
8. Properties of unusual virus revealed in research
9. U of Minnesota researcher finds link between aggression, status and sex
10. Researchers study virus with unusual properties
11. Dune and dirty: Hurricane teaches lessons through ecosystem research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... -- The report "Video Surveillance Market by ... Devices), Software (Video Analytics, VMS), and Service (VSaaS, Installation ... 2022", published by MarketsandMarkets, the market was valued at ... reach USD 75.64 Billion by 2022, at a CAGR ... considered for the study is 2016 and the forecast ...
(Date:3/23/2017)... Research and Markets has announced the addition of the ... to 2025" report to their offering. ... The Global Vehicle Anti-Theft System Market ... the next decade to reach approximately $14.21 billion by 2025. ... for all the given segments on global as well as regional ...
(Date:3/20/2017)... -- PMD Healthcare announces the release of its new ... (WMS), a remote, real-time lung health monitoring and management ... a Medical Device, Digital Health, and Chronic Care Management ... solutions that empower people to improve their healthcare and ... the first ever personal spirometer, Spiro PD, which was ...
Breaking Biology News(10 mins):
(Date:5/18/2017)... Mass. (PRWEB) , ... May 18, 2017 , ... ... the procedure on April 28, 2017 at the Prince Of Wales Private Hospital. ... cervical disc at level C6-C7. The patient failed conservative treatments prior to undergoing ...
(Date:5/18/2017)... ... May 16, 2017 , ... Clinical Supplies Management (“CSM”), a ... the company continues to grow. CSM has doubled in size over the past ... an aggressive growth strategy. , Roger Gasper joins CSM as Chief Financial Officer. ...
(Date:5/18/2017)... ... May 17, 2017 , ... ... expertise, and further enhances its scientific power by providing investigators access to ... has agreed to join the scientific advisory board. “We are committed to ...
(Date:5/18/2017)... ... May 17, 2017 , ... ... business process optimization firm for the life sciences and healthcare industries, is honored ... and Traceability for Medical Devices conference in Brussels, Belgium. , Crowley played a ...
Breaking Biology Technology: