Navigation Links
UQ research targets West Nile virus and dengue fever
Date:12/11/2008

Research conducted at The University of Queensland could contribute to the development of a vaccine and cure for West Nile virus and Dengue fever.

Led by Associate Professor Alexander Khromykh, a team of researchers from UQ's School of Molecular and Microbial Sciences identified a novel characteristic of the virus family to which these diseases belong.

The team found all flaviviruses produced a small molecule which, among other functions, controlled the host's response to viral infection.

This molecule, called a subgenomic noncoding ribonucleic acid (sfRNA), is a part of the virus genome.

"To develop new and effective antiviral strategies, we have to know as much as possible about the virus, or virus family, that we are fighting," Dr Khromykh said.

"As sfRNA is produced by all flaviviruses we tested so far, targeting it with an antiviral therapy may be effective for the whole range of flaviviruses.

"By using reverse genetic engineering we were able to generate viruses that do not produce this sfRNA and showed that these engineered viruses are no longer able to kill their hosts or elicit disease symptoms.

"These engineered viruses offer great potential as vaccine candidates as they are expected to elicit an antiviral immune response similar to the normal virus infection without causing a disease."

Dr Khromykh said by studying mice infected with these engineered West Nile viruses, the team learned more about how the body attempted to combat a flavivirus infection.

The part of the virus the infected cells in the body are unsuccessful in destroying forms the sfRNA, which helps the virus to kill cells and cause potentially deadly diseases, he said.

"We identified sfRNA as a potential antiviral target for the large group of medically important viruses," Dr Khromykh said.

"Moreover, the knowledge obtained from our studies with West Nile virus should be readily applicable for designing anti-viral drugs and engineering similar vaccine candidates for other medically important flaviviruses."


'/>"/>

Contact: Penny Robinson
penny.robinson@uq.edu.au
61-733-659-723
Research Australia
Source:Eurekalert

Related biology news :

1. CSHL researchers map changing epigenetic modifications that enable transposons to run amok
2. New research shows how gene function drives natural selection in important class of genetic elements
3. UNH researchers track lobster migrations to improve population estimates
4. Siblings of mentally disabled face own lifelong challenges, according to researchers
5. Caltech researchers get first look at how groups of cells coordinate their movements
6. Computation and genomics data drive bacterial research into new golden age
7. Leeds research points to new therapy for hepatitis C treatment
8. Properties of unusual virus revealed in research
9. U of Minnesota researcher finds link between aggression, status and sex
10. Researchers study virus with unusual properties
11. Dune and dirty: Hurricane teaches lessons through ecosystem research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/7/2017)... -- Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH), ... the LEERINK Partners 6th Annual Global Healthcare Conference at ... 15, 2017 at 10 a.m. Eastern Time. ... accessed at http://wsw.com/webcast/leerink28/zbh .  The webcast will be ... Investor Relations website at http://investor.zimmerbiomet.com . ...
(Date:2/3/2017)... Biomedical Research Institute announced that its Board of Trustees has ... Institute,s new President and CEO. Dr. Schlesinger will take the ... currently the Chair of the Department of Microbial Infection and ... at Ohio State University. "We are delighted to ... Texas Biomed," said Dr. James O. Rubin , Board ...
(Date:2/2/2017)... NEW YORK , Feb. 2, 2017  EyeLock ... has released a new white paper " What You ... The problem of ensuring user authenticity is a ... protect the authentication of users. However, traditional authentication schemes ... Biometric authentication offers an elegant ...
Breaking Biology News(10 mins):
(Date:2/18/2017)... ... February 17, 2017 , ... The BMT ... the Center for International Blood & Marrow Transplant Research (CIBMTR) will take place ... , The combined scientific sessions offer investigators, clinicians, laboratory technicians, clinical research ...
(Date:2/17/2017)... February 17, 2017 According ... by Product (Consumables, Service), Type (Safety, Efficacy, Validation), ... Drug Discovery and Development, Disease-Risk) - Global Forecast ... projected to reach USD 53.34 Billion by 2021 ... a CAGR of 13.8% during the forecast period ...
(Date:2/17/2017)... ... February 17, 2017 , ... Academy of Model Aeronautics (AMA), ... maker of unmanned aircraft systems (UAS), are launching a joint program to promote ... and support educational outreach efforts. , AMA and DJI will collaborate on other ...
(Date:2/16/2017)... ... , ... Avomeen & MichBio will be hosting a BioMixer next week Thursday, ... Services (4840 Venture Dr., Ann Arbor, Michigan 48108). BioMixers are a casual, members-only ... with peers, make new connections and talk bio biz. , Cost:, ...
Breaking Biology Technology: