Navigation Links
UPCI researchers target 'cell sleep' to lower chances of cancer recurrence
Date:8/1/2013

PITTSBURGH, Aug. 1, 2013 An international research team led by University of Pittsburgh Cancer Institute (UPCI) scientists discovered that by preventing cancer cells from entering a state of cellular sleep, cancer drugs are more effective, and there is a lower chance of cancer recurrence. The findings, which will be published in the August 15 issue of the journal Cancer Research and are available online, are the first to show that it is possible to therapeutically target cancer cells to keep them from entering a cellular state called quiescence, or "cell sleep." Quiescence can be a dangerous source of tumor recurrence because cancer drugs don't typically destroy quiescent cells.

"Successful cancer therapy often is hampered by tumor cell quiescence because these cells remain viable and are a reservoir for tumor progression," said Anette Duensing, M.D., assistant professor of pathology at UPCI. "By inhibiting a key regulator of quiescence, we are able to kill a larger fraction of cancer cells."

Dr. Duensing and her colleagues made the discovery while studying gastrointestinal stromal tumors (GISTs), which are uncommon tumors that begin in the walls of the gastrointestinal tract. According to the American Cancer Society, about 5,000 cases of GISTs occur each year in the United States with an estimated five-year survival rate of 45 percent in patients with advanced disease.

GISTs are caused by a single gene mutation, which means they can be successfully treated with the targeted therapy drug imatinib, known by the trade name Gleevec. Unlike traditional chemotherapy, which kills all rapidly dividing cells, targeted therapy stops cancer by interfering with specific molecules needed for tumor growth.

Unfortunately, GISTs rapidly develop resistance to the treatment and complete cancer remission using Gleevec is rare. A key regulator of the cancer cell sleep process is a protein complex called DREAM, which is named for the multiple pro
'/>"/>

Contact: Allison Hydzik
hydzikam@upmc.edu
412-647-9975
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. UNH researchers find African farmers need better climate change data to improve farming practices
5. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
6. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
7. Researchers print live cells with a standard inkjet printer
8. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
9. Researchers reveal how a single gene mutation leads to uncontrolled obesity
10. Researchers discover novel therapy for Crohns disease
11. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... 1, 2014 Smart technology emphasis grows ... and improved security: NXT-ID, Inc. (OTCBB: NXTD), eBay Inc. (NASDAQ: ... ), Apple Inc. (NASDAQ: AAPL ), Visa Inc. ... NXT-ID, Inc., (OTCQB: NXTD) a biometric authentication company focused ... the second series of 30 second spots on CNBC for ...
(Date:7/10/2014)... SHELTON, Conn. , July 2, 2014 NXT-ID, Inc., ... market, reports that CEO Mr. Gino Pereira was ... radio show in Tampa Florida . Mr. ... radio host Cedric Harris and how the Wocket™ ... secure alternative.  Cedric Harris tells ...
(Date:7/10/2014)... GOTHENBURG, Sweden , July 7, 2014 ... won its first major design win (DW). A Chinese Top ... with the planned start of mass production in October 2014. ... with a Chinese Top 5 smartphone OEM, which has a ... 2014 and a target sales volume for this phone of ...
Breaking Biology News(10 mins):Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 2Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 3Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 4Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 5Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 2Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 3Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 4FPC Wins DW for 1021 Touch Sensor for Flagship Smartphone from Chinese Top 5 Smartphone OEM 2
... Va.Coinciding with the observance of Nuclear Medicine Week (October ... (October), SNM released today a new fact sheet highlighting ... improving the ways in which breast cancer is diagnosed ... effective, safe and painless imaging tool for diagnosing and ...
... a study in mice has found that inactivating a ... increase energy expenditure and help lower diet-induced obesity. These ... might lead to some new roads in weight-loss ... to continually "burn fat" in order to maintain body ...
... of spring: a swarm of bees on the move. But how ... of the community know the way remains a mystery. Curious to ... homes, Tom Seeley, a neurobiologist from Cornell University, and engineers Kevin ... to find out how swarms are guided to their new home ...
Cached Biology News:SNM releases new fact sheet on breast cancer and molecular imaging 2Making metabolism more inefficient can reduce obesity 2Bee swarms follow high-speed 'streaker' bees to find a new nest 2
(Date:7/10/2014)... 10, 2014 OMICS Group’s 5th International ... 18-20 August, 2014 at Double Tree by Hilton Beijing, ... developments in Analytical & Bioanalytical research methods only to ... on this occasion, Dr. Srinubabu Gedela, MD of OMICS ... is a remarkable one in bringing a unique and ...
(Date:7/10/2014)... 2014 Senior supply chain management executives ... addressed the challenges of “Reducing Cost, Lead Time, & ... strategic sourcing. Describing the partnership of the Bio Supply ... Management Institute ( SCMI) of the University of ... at the Kroc Institute of Peace and Justice in ...
(Date:7/10/2014)... 10, 2014 On July 9 ... , presented Russia,s first national ... The Company is developing a unique project called ... develops a number of innovative drugs based on monoclonal ... ceremony took place at the International Exhibition "Innoprom 2014" ...
(Date:7/10/2014)... 10, 2014 /PRNewswire-iReach/ -- Tute Genomics, the ... announced an agreement with Lineagen, Inc., to ... NextStep Dx PLUS.  Lineagen, focused on ... disorders, currently offers FirstStep Dx PLUS, ... used by healthcare providers as a first-line ...
Breaking Biology Technology:A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4
... JOLLA, Calif., Sept. 11 TorreyPines Therapeutics,Inc. (Nasdaq: ... Kurtz, President and,Chief Executive Officer of TorreyPines, will ... Tuesday, September 18th at 2:30 p.m., local,time (5:30 ... presentation will be available live. You can,access the ...
... of Novel Strategies to Induce and Monitor Humoral and ... Infection by Respiratory Viruses, LEIDEN, The Netherlands, September ... Institute Pharma is being conducted by a,multi-member Dutch consortium ... development. The aim of the project is to develop,novel ...
... Sept. 11 Jazz,Pharmaceuticals, Inc. (Nasdaq: JAZZ ... Chief Executive Officer, will provide a corporate,presentation at ... NY on,September 24, 2007 at 4:00 p.m. Eastern ... may be accessed by visiting the,Investors section of ...
Cached Biology Technology:A Large-Scale Research Project by a Dutch Consortium Addressing a Global Problem 2A Large-Scale Research Project by a Dutch Consortium Addressing a Global Problem 3A Large-Scale Research Project by a Dutch Consortium Addressing a Global Problem 4A Large-Scale Research Project by a Dutch Consortium Addressing a Global Problem 5
... activity is expressed in g per ml and ... saline, pH 6.8, of a 1 mg per ... lowest concentration to agglutinate a 2% suspension of ... incubation at 25 C. Preparation Note: ...
... These handy dispensers save space ... wipers, hats, and other garb. ... storage bins for small parts ... manufacturing. Clear acrylic. Open-slot design ...
... Proteolytic degradation is critical to the ... and regulatory proteins as important and ... metabolism, heat shock and stress response, ... receptors and ion channels, cell cycle ...
... houses Ocean Optics LIBS2000+ Spectrometers (sold separately) ... (UP) Ablation Chamber to offer numerous configuration ... systems features include a high-power 1064 nm ... precise X-Y sample positioning, laser spot diameter ...
Biology Products: