Navigation Links
UNC team discovers promising target for new pancreatic cancer treatments
Date:11/5/2010

Chapel Hill, NC One of the most frustrating problems faced by doctors who treat pancreatic cancer is the lack of effective therapeutic options. More than 38,000 people in the United States die of the disease each year, and new drugs and treatments are desperately needed.

For almost three decades, scientists and physicians have known that a gene called the KRAS oncogene is mutated in virtually all pancreatic cancers, making it an important target for scientists looking for a way to stop the growth of pancreatic cancer tumors. The problem is that the KRAS gene triggers cancer cell growth in numerous ways, through multiple cell signaling pathways, and scientists have had difficulty determining which one will be the most promising to block an important first step in designing a drug for use in patients.

In a paper published today in the Journal of Biological Chemistry, a team from UNC Lineberger Comprehensive Cancer Center has narrowed the focus of this scientific quest to a protein called RGL2.

According to Channing Der, PhD, who led the research, "The pathway we talk about this paper is one we have investigating for more than five years. We think it is an attractive target for achieving what has, to date, been impossible: making a KRAS-blocking drug."

Der, who is a distinguished professor of pharmacology and UNC Lineberger member, says, "We are particularly optimistic about RGL2 because we know that this protein is a critical component of KRAS signaling to another class of proteins called Ral GTPases, which are essential for the growth of almost all pancreatic tumors."

Working with Jen Jen Yeh, MD, assistant professor of surgery, Sharon Campbell, PhD, professor of biochemistry and biophysics, Der and his laboratory team were able to demonstrate that RGL2 is overexpressed not only in pancreatic tumor cells grown in the laboratory but also in tissue taken from pancreatic cancer patients.

According to Der, "Many ideas work in the artificial environment of cell culture but not in real cancer patients. Our work with actual pancreatic tumor tissue makes us optimistic that our new understanding of this pathway can lead to a therapeutic impact for the cancer patient."


'/>"/>

Contact: Ellen de Graffenreid
edegraff@med.unc.edu
919-962-3405
University of North Carolina School of Medicine
Source:Eurekalert

Related biology news :

1. International team discovers gene associated with epilepsy
2. Texas A&M anthropologist discovers long-lost primate in Indonesia
3. Stowers Institutes Workman Lab discovers novel histone demethylase protein complex
4. UCSF discovers new glucose-regulating protein linked with diabetes
5. Biologist discovers pink-winged moth in Chiracahua Mountains
6. NTU professor discovers method to efficiently produce less toxic drugs using organic molecules
7. La Jolla Institute discovers novel tumor suppressor
8. IU discovers stone tools, rare animal bones -- clues to Caribbeans earliest inhabitants
9. Case Western Reserve University discovers Merkel cell originates from skin, not the neural crest
10. Iowa State University researcher discovers Ebolas deadly secret
11. CSHL-led team discovers rare mutation dramatically increasing schizophrenia risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2017)... , April 17, 2017 NXT-ID, Inc. ... company, announces the filing of its 2016 Annual Report on Form ... Exchange Commission. ... Form 10-K is available in the Investor Relations section of the ... on the SEC,s website at http://www.sec.gov . 2016 ...
(Date:4/11/2017)... , April 11, 2017 No ... but researchers at the New York University Tandon ... of Engineering have found that partial similarities between ... systems used in mobile phones and other electronic ... The vulnerability lies in the fact ...
(Date:4/5/2017)... , April 4, 2017 KEY FINDINGS ... anticipated to expand at a CAGR of 25.76% during ... diseases is the primary factor for the growth of ... report: https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global ... product, technology, application, and geography. The stem cell market ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... ... August 15, 2017 , ... JULABO USA introduces its new ... website makes it easy to navigate through the site whether you’re in the ... product information, educational industry content and visit the company’s social media accounts, all ...
(Date:8/11/2017)... , Aug. 11, 2017  Market ... New York Times article regarding the telemedicine ... according to Kalorama Information.  The article, ... for That"  used information from Kalorama ... Monitoring & Telemedicine Market  (Sleep, Diabetes, ...
(Date:8/10/2017)... ... August 09, 2017 , ... As ... industry reach its ideal customers with the right message. Their effective, cutting-edge inbound ... Midwest company, we realize how crucial the agriculture industry is,” said David Phelps, ...
(Date:8/10/2017)... (PRWEB) , ... August 09, 2017 , ... Okyanos Center ... take place at the Pelican Bay Hotel in Freeport, Grand Bahama on September 27, ... is required. , With oversight from the Ministry of Health’s National Stem Cell ...
Breaking Biology Technology: