Navigation Links
UNC study helps clarify link between high-fat diet and type 2 diabetes
Date:4/11/2011

CHAPEL HILL, N.C. A diet high in saturated fat is a key contributor to type 2 diabetes, a major health threat worldwide. Several decades ago scientists noticed that people with type 2 diabetes have overly active immune responses, leaving their bodies rife with inflammatory chemicals.

In addition, people who acquire the disease are typically obese and are resistant to insulin, the hormone that removes sugar from the blood and stores it as energy.

For years no one has known exactly how the three characteristics are related. But a handful of studies suggest that they are inextricably linked.

New research from the University of North Carolina at Chapel Hill School of Medicine adds clarity to the connection. The study published online April 10 in the journal Nature Immunology finds that saturated fatty acids but not the unsaturated type can activate immune cells to produce an inflammatory protein, called interleukin-1beta.

"The cellular path that mediates fatty acid metabolism is also the one that causes interleukin-1beta production," says senior study co-author Jenny Y. Ting, PhD, William Kenan Rand Professor in the Department of Microbiology and Immunology.

"Interleukin-1beta then acts on tissues and organs such as the liver, muscle and fat (adipose) to turn off their response to insulin, making them insulin resistant. As a result, activation of this pathway by fatty acid can lead to insulin resistance and type 2 diabetes symptoms." Ting is also a member of the UNC Lineberger Comprehensive Cancer Center, and the UNC Inflammatory Diseases Institute.


'/>"/>

Contact: Les Lang
llang@med.unc.edu
919-966-9366
University of North Carolina School of Medicine
Source:Eurekalert  

Page: 1

Related biology news :

1. Clinical study suggests estrogen levels and breast health can be altered
2. New genetic study helps to solve Darwins mystery about the ancient evolution of flowering plants
3. People control thoughts better when they see their brain activity: UBC study
4. Soy increases effectiveness of radiation at killing lung cancer, Wayne State study shows
5. Chimpanzees contagious yawning evidence of empathy, not just sleepiness, study shows
6. Chemical engineers at UCSB design molecular probe to study disease
7. Birds must choose between mating, migrating, study finds
8. Study finds link between chronic depression and accelerated immune cell aging
9. Drought-exposed leaves adversely affect soil nutrients, study shows
10. Economics, physics are roadblocks for mass-scale algae biodiesel production, study finds
11. Chimp, bonobo study sheds light on the social brain
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UNC study helps clarify link between high-fat diet and type 2 diabetes
(Date:3/2/2017)... March 2, 2017 Summary This ... understand Merck KGaA and its partnering interests and activities ... Description The Partnering Deals and Alliance since ... activity of one of the world,s leading life sciences ... upon purchase to ensure inclusion of the most up ...
(Date:2/28/2017)... --  Acuant , a leading provider of data capture ... new and core technologies building upon the acquisition of ... desktop Acuant FRM TM facial recognition and match ... manual review of identity documents by accredited professionals. ... most accurate capture software to streamline workflows by securely ...
(Date:2/26/2017)... DALLAS , Feb. 25, 2017  Securus ... justice technology solutions for public safety, investigation, corrections ... of Recidivism and Reentry. "Too often, ... State prisons and county jails are trying to ... of inmates and friends and family members. While significant ...
Breaking Biology News(10 mins):
(Date:3/22/2017)... 22, 2017  Ascendis Pharma A/S (Nasdaq: ASND), ... technology to address significant unmet medical needs in ... full year ended December 31, 2016. ... company as we broadened our pipeline and pursued ... disease company with an initial focus on endocrinology," ...
(Date:3/22/2017)... 2017 Good Start Genetics, a leading family ... 130 million covered lives mark through its most recent ... Texas . With newly signed contracts nationally and ... strong payor acceptance based on the quality of its ... counseling, its industry-leading customer care and support and its ...
(Date:3/22/2017)... March 22, 2017   iSpecimen ®, the ... Doctors Pathology Service (DPS), a full-service anatomic ... the United States , has joined a ... Information Network (DHIN) to make human biospecimens and ... The novel program, announced in 2015 as a collaboration ...
(Date:3/22/2017)... 2017 MarketNewsUpdates.com News Commentary  ... The traditional ways ... pressured as of late due to the rise of the ... a dramatic impact on patient,s quality of life as Biotech ... identifying new forms of opioid formulations that prevent abuse. Biotech ...
Breaking Biology Technology: