Navigation Links
UNC study helps clarify link between high-fat diet and type 2 diabetes
Date:4/11/2011

CHAPEL HILL, N.C. A diet high in saturated fat is a key contributor to type 2 diabetes, a major health threat worldwide. Several decades ago scientists noticed that people with type 2 diabetes have overly active immune responses, leaving their bodies rife with inflammatory chemicals.

In addition, people who acquire the disease are typically obese and are resistant to insulin, the hormone that removes sugar from the blood and stores it as energy.

For years no one has known exactly how the three characteristics are related. But a handful of studies suggest that they are inextricably linked.

New research from the University of North Carolina at Chapel Hill School of Medicine adds clarity to the connection. The study published online April 10 in the journal Nature Immunology finds that saturated fatty acids but not the unsaturated type can activate immune cells to produce an inflammatory protein, called interleukin-1beta.

"The cellular path that mediates fatty acid metabolism is also the one that causes interleukin-1beta production," says senior study co-author Jenny Y. Ting, PhD, William Kenan Rand Professor in the Department of Microbiology and Immunology.

"Interleukin-1beta then acts on tissues and organs such as the liver, muscle and fat (adipose) to turn off their response to insulin, making them insulin resistant. As a result, activation of this pathway by fatty acid can lead to insulin resistance and type 2 diabetes symptoms." Ting is also a member of the UNC Lineberger Comprehensive Cancer Center, and the UNC Inflammatory Diseases Institute.


'/>"/>

Contact: Les Lang
llang@med.unc.edu
919-966-9366
University of North Carolina School of Medicine
Source:Eurekalert  

Page: 1

Related biology news :

1. Clinical study suggests estrogen levels and breast health can be altered
2. New genetic study helps to solve Darwins mystery about the ancient evolution of flowering plants
3. People control thoughts better when they see their brain activity: UBC study
4. Soy increases effectiveness of radiation at killing lung cancer, Wayne State study shows
5. Chimpanzees contagious yawning evidence of empathy, not just sleepiness, study shows
6. Chemical engineers at UCSB design molecular probe to study disease
7. Birds must choose between mating, migrating, study finds
8. Study finds link between chronic depression and accelerated immune cell aging
9. Drought-exposed leaves adversely affect soil nutrients, study shows
10. Economics, physics are roadblocks for mass-scale algae biodiesel production, study finds
11. Chimp, bonobo study sheds light on the social brain
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UNC study helps clarify link between high-fat diet and type 2 diabetes
(Date:4/17/2014)... have hit on a novel method to help ... and most effective treatment possible., Kidney stones represent ... developing world. If left untreated, apart from being ... and other complications. In many patients treated successfully, ... more effective pathological approach to diagnosis and treatment ...
(Date:4/17/2014)... meeting painted a stark warning on the possible effects ... greenhouse effect 32 times that of carbon dioxide. Now ... substances act as fully regenerable electron acceptors which helps ... wetlands instead of being released to the atmosphere. However, ... it may enter into a vicious cycle to release ...
(Date:4/17/2014)... University researchers have detected new early-warning signs of the ... could have far-reaching implications for the diagnosis and treatment ... 25 million Americans. , "We had not expected to ... early stages," said Ann Elsner, professor and associate dean ... of the study. "We set out to study the ...
Breaking Biology News(10 mins):Methane climate change risk suggested by proof of redox cycling of humic substances 2New technique detects microscopic diabetes-related eye damage 2New technique detects microscopic diabetes-related eye damage 3
... Gary Hoyle, PhD, professor, University of Louisville School of ... research to develop an effective medical treatment to counteract ... of terrorism. The National Institute of Environmental Health Sciences ... have awarded Hoyle $2.6 million over five-years to further ...
... in the southeastern United States, and for scientists trying to ... ) is not cooperating. So far botanists have ... plant to boiling water, dry heat up to 284 degrees ... coax them into germination. Nothing has worked. "Complete ...
... and conservation successes in the face of rapid environmental ... plants adapt to local climate. To improve scientists, ... 7, 2011 issue of Science helps define ... The National Science Foundation partly funded the study, ...
Cached Biology News:UofL researcher awarded $2.6 million NIH grant renewal 2Super-tough seed coat keeps Michaux's sumac on critically endangered list 2
(Date:1/15/2014)... and SAN JOSE, California , January 15, ... developing antibody-drug conjugates for cancer, today announced the appointment of ... Dr Reynolds has over 20 years, development experience gained in ... Seattle Genetics. "I am delighted to welcome Tom ...
(Date:1/15/2014)... Toronto, Canada (PRWEB) January 15, 2014 ... perspectives on nonclinical and clinical safety assessment in biosimilars. ... a path for biosimilar drug development, however the complex ... regards to quality, safety and efficacy extremely challenging. Based ...
(Date:1/15/2014)... 2014 More than 5 million Americans ... in 3 seniors will die with Alzheimer’s or another ... figures have shocked many Americans into looking for ways ... these tragic age-related cognitive disorders. Jonathan Weisman, president of ...
(Date:1/15/2014)... 2014 The Microcompetition with Foreign DNA theory ... of these latent viruses is the Epstein Barr Virus (EBV), ... arthritis (RA) is a chronic inflammatory disease that destroys the ... that RA patients have high concentrations of EBV DNA in ...
Breaking Biology Technology:Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3
... April 12, 2011 Drs. Rodney Landreneau and ... non small cell lung cancer study at the 2011 Society ... Landreneau is Director of the Lung Center at UPMC Shady ... at UPMC Passavant Medical Center and Director of the Division ...
... 12, 2011 Biotech Medical, Inc. is set to ... SpectraSan™ "Hungry Enzymes". The products will be available for ... a Pet Stain & Odor Eraser, Spa & Whirlpool ... All-Purpose Cleaner & Degreaser, Glass & Stainless Steel Cleaner ...
... Dr. Fresh®, Inc., maker of the popular FireFly® children,s ... to raise awareness and funds for Smile Train, the ... company will donate $1 for every new "Like" on ... Smile Train.  The organization provides life-changing surgery for poor ...
Cached Biology Technology:Precision Therapeutics' ChemoFx® Demonstrates Significant Role in Selection of Chemotherapy Doublets in Non Small Cell Lung Cancer 2Biotech Medical, Inc. Introduces a Full Line of Enzyme Cleaners 2FireFly® Toothbrush Facebook Campaign Raises Funds for Smile Train 2