Navigation Links
UNC spin-off receives $3 million Small Business Innovation Research Grant
Date:9/29/2011

Chapel Hill, NC G-Zero Therapeutics, an RTP company started in 2008 based on technologies from the University of North Carolina at Chapel Hill, has been awarded a $3 million Phase II Small Business Innovation Research Grant from the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health.

The grant will fund commercialization of technology developed by UNC professor of medicine and genetics, Norman Sharpless, MD, to protect patients from cellular damage caused by radiation or cancer chemotherapy.

Sharpless, who is associate director for translational research at UNC Lineberger Comprehensive Cancer Center, leads a team that has been testing drugs to inhibit enzymes involved in cell division. His group showed that treatment with certain of these agents causes specific groups of bone marrow cells to temporarily stop dividing (which they termed 'pharmacological quiescence' or PQ).

Scientists have demonstrated that cells which are not dividing are resistant to agents that damage DNA, like radiation and chemotherapy. Therefore, by inducing PQ with potent and selective inhibitors of cell division, Sharpless has shown mice are protected from lethal doses of radiation and chemotherapy. Previously, Sharpless' lab has shown that the induction of PQTM even up to 20 hours after radiation exposure protects mice from a lethal dose of radiation. As opposed to existing technologies to prevent radiation or chemotherapy toxicity, PQ protects all the normal cells of blood, including platelets, red cells and white cells.

This technology has been licensed to G-Zero Therapeutics, which will use this new funding to further commercialize these discoveries. The research was also funded by an innovation grant from the University Cancer Research Fund.

"Our goal is a simple, non-toxic pill that decreases radiation toxicity even when given after radiation exposure. We believe this approach coul
'/>"/>

Contact: Ellen de Graffenreid
edegraff@med.unc.edu
919-962-3405
University of North Carolina School of Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Tyco International To Pursue Spin-Off of Electrical & Metal Products Business
2. TGen spin-off MedTrust Online enables cancer doctors to quickly obtain best-available information
3. Diaphragm pacing system receives FDA approval for use with ALS patients
4. University of Oklahoma ecology and evolutionary biology graduate student receives EPAs STAR Fellowship award
5. Salk scientist receives distinguished NIH award for transformative research
6. University of Pittsburgh receives $3.54 million translational bioengineering research award
7. UOG entomologist receives new grant monies to combat the rhino beetle
8. Danforth Center Collaborative Research Program receives funding to improve crop yield in Africa
9. Marine Science Institute receives $7 Million grant to study the impact of the Deepwater Horizon
10. UC Riverside plant biotechnologist receives prestigious Jefferson Science Fellowship
11. Hawaii receives funding for liver cancer research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... learned a great deal about complex social behavior by ... something to teach too. , With their unusually large ... parrots live in a complex social environment---not merely in ... or ants, but in a dynamic setting of alliances ... intelligent mammals: dolphins, whales, primates, and social carnivores, like ...
(Date:9/16/2014)... Environmental Health at the Mailman School of Public Health ... asthma and prenatal exposure to two phthalates used in ... in the journal Environmental Health Perspectives . ... higher levels of the chemicals, butylbenzyl phthalate (BBzP) and ... percent increase in risk of developing asthma between age ...
(Date:9/16/2014)... CLEVELAND, Ohio (September 17, 2014)The North American Menopause ... for the comprehensive care of midlife womenon everything ... feature, "The North American Menopause Society Recommendations for ... today in the Society,s journal Menopause . ... recommendations for the care of midlife women freely ...
Breaking Biology News(10 mins):Being social: Learning from the behavior of birds 2Phthalates heighten risk for childhood asthma 2Phthalates heighten risk for childhood asthma 3
... A team of scientists from the University Hospitals of ... bowel diseases have low bone mass and poor bone architecture ... at increased risk of fracture. Inflammatory bowel disease ... inflammation of the bowel. Two of the most common disorders ...
... new study presented today at the World Congress on ... a commonly used injectible contraceptive, is associated with higher ... in combination with estrogens. Depot medroxyprogesterone acetate ... birth control drug which is injected every 3 months. ...
... muscle tissue experiences trauma or disease, such as ... as "satellite cells" respond to repair and regenerate ... neuromuscular diseases, such as muscular dystrophy, which affect ... researchers have used time-lapse photography to document satellite ...
Cached Biology News:Caught on tape: Muscle stem cells captured on video by MU researcher 2
(Date:9/17/2014)... (PRWEB) September 17, 2014 Escape Alert, LLC ... pets which will alert owners if their pet has escaped ... from an implanted microchip in the pet’s body. This is ... for pets have been around for many years, they are ... not able to track a pet’s location or alert the owner ...
(Date:9/17/2014)... September 17, 2014 NASA’s MESSENGER has ... Engineering Corporation is proud to have one of its ... MESSENGER mission is a scientific investigation of the planet ... be sent there, and has provided a vast amount ... V27200 family of latch valves utilize solenoids that also ...
(Date:9/17/2014)... September 17, 2014 The ... , a multi-stakeholder non-profit collaborative building a global ... clinical research, today announced Phase 3 of its ... , Amir H. Kalali, Vice-President, Global Head, ... Bajpai, President, Compliance and Quality Integration (CQI) Consulting ...
(Date:9/16/2014)... 2014 This report analyzes the worldwide markets for ... Hardware, and Biocontent. The report provides separate comprehensive analytics for ... , Europe , Asia-Pacific ... of World. Annual estimates and forecasts are provided for the ... provided for these markets. Market data and analytics are derived ...
Breaking Biology Technology:Implantable Microchip for Pets with GPS Tracking - Patent Filed by Escape Alert, LLC. 2Implantable Microchip for Pets with GPS Tracking - Patent Filed by Escape Alert, LLC. 3Global Standards Initiative for Clinical Research Sites Advances 2Global Standards Initiative for Clinical Research Sites Advances 3Global Standards Initiative for Clinical Research Sites Advances 4Global Bioinformatics Industry 2Global Bioinformatics Industry 3Global Bioinformatics Industry 4Global Bioinformatics Industry 5Global Bioinformatics Industry 6Global Bioinformatics Industry 7Global Bioinformatics Industry 8Global Bioinformatics Industry 9Global Bioinformatics Industry 10Global Bioinformatics Industry 11Global Bioinformatics Industry 12Global Bioinformatics Industry 13Global Bioinformatics Industry 14Global Bioinformatics Industry 15Global Bioinformatics Industry 16Global Bioinformatics Industry 17Global Bioinformatics Industry 18Global Bioinformatics Industry 19Global Bioinformatics Industry 20Global Bioinformatics Industry 21Global Bioinformatics Industry 22Global Bioinformatics Industry 23
... photonics and renewable energy will be the focus of ... to 14, 2009 at McMaster University in Hamilton, Ontario, ... in conjunction with the event. , The 4th Nano ... the 14th Canadian Semiconductor Technology Conference (CSTC2009) will bring ...
... UC Riverside have made an accidental discovery in ... information in computers can be transported or stored. ... electrons possess that makes them behave like tiny ... of spin-based semiconductor technology such as ultrahigh-speed computers. ...
... programs give sponsors easy-to-use tools to store, mine and ... transfer knowledge base to ensure enrollment success, NEWTON, ... technology leader, announced the release of a new,product, "Center ... in-house recruitment capabilities for clinical,trial sponsors. The goal is ...
Cached Biology Technology:Joint nanotechnology forum to focus on electronics, photonics, renewable energy 2Discovery by UC Riverside physicists could enable development of faster computers 2Discovery by UC Riverside physicists could enable development of faster computers 3TCN e-Systems Offers Trial Sponsors Solutions for Creating In-House Center of Excellence in Patient Recruitment 2TCN e-Systems Offers Trial Sponsors Solutions for Creating In-House Center of Excellence in Patient Recruitment 3TCN e-Systems Offers Trial Sponsors Solutions for Creating In-House Center of Excellence in Patient Recruitment 4
Anti-ADAM-12 (Meltrin Alpha); amino terminal region; rabbit host...
Mouse monoclonal [3G8] to MDMA ( Abpromise for all tested applications)....
Fluorescein isothiocyanate (FITC) mouse anti-human IFN-alpha2 25 tests...
Rabbit Anti-melatonin (different linkage) Polyclonal Antibody...
Biology Products: