Navigation Links
UNC scientists win $1.6 million stimulus award to accelerate decoding of human genome
Date:10/15/2009

Ever since the first genome sequence was published in 2001, scientists have been working to figure out what the sequence means. An analogy is walking across a desert and finding a large book in a language you don't know, then trying to figure out what the book is saying.

"In the case of the human genome, the book is a blueprint to building cellsand ultimatelythe whole human. But we don't yet understand its language," said Morgan Giddings, Ph.D., associate professor of microbiology and immunology and of biomedical engineering at the University of North Carolina at Chapel Hill.

Giddings and UNC colleague Xian Chen, Ph.D., associate professor of biochemistry and biophysics, have been developing methods for decoding the human blueprint by studying the things the blueprint produces: proteins. They relate the proteins back to the blueprint itself, to further decode the language of the genome blueprint.

Giddings and Chen have been awarded a $1.6 million 2-year "Grand Opportunities" (GO) grant from the National Human Genome Research Institute to accelerate this research. Their effort will be part of a consortium of investigators studying the human genome blueprint, titled the "ENCyclopedia Of DNA Elements" (ENCODE). The consortium's overall goal is to assemble a comprehensive catalog of functional elements in the human genome.

With their GO grant, Giddings and Chen will generate, analyze, and release to the public large-scale data sets that allow linking of the protein products in cells to their genomic blueprints. According to Giddings, "this will significantly promote our understanding of the language of the human genome, enhancing efforts to solve pressing human health issues like heart disease and cancer by understanding how errors in the blueprint lead to disease, and how we might fix those errors."

Giddings is a member of the Carolina Center for Genome Sciences, and Chen is technology development director for
'/>"/>

Contact: Les Lang
llang@med.unc.edu
919-966-9366
University of North Carolina School of Medicine
Source:Eurekalert  

Page: 1 2

Related biology news :

1. UK scientists working to help cut ID theft
2. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
3. Comet probes reveal evidence of origin of life, scientists claim
4. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
5. Male elephants get photo IDs from scientists
6. Scientists retrace evolution with first atomic structure of an ancient protein
7. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
8. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
9. Clemson scientists shed light on molecules in living cells
10. Scientists tackle mystery mountain illness
11. T. rex quicker than Becks, say scientists
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UNC scientists win $1.6 million stimulus award to accelerate decoding of human genome
(Date:7/28/2014)... the bug hunter, but the target of his work ... identified with special methods and instruments. Benjamin Hause, an ... Laboratory at Kansas State University, recently published an article ... is an important find in the United States. , ... know what it was," Hause said. "We used next-generation ...
(Date:7/28/2014)... that can help advance the genetic engineering of ... has been developed by researchers with the U.S. ... a multi-institutional partnership led by Lawrence Berkeley National ... an assay that enables scientists to identify and ... components in the biosynthesis of plant cell walls. ...
(Date:7/28/2014)... for Biologically Inspired Engineering at Harvard University today ... commercialized by a newly formed private company to ... medicine products. The announcement follows a ... Development (OTD) and the start-up Emulate Inc., relating ... Organs-on-Chips platform. , "This is a big ...
Breaking Biology News(10 mins):Researcher using next-generation sequencing to rapidly identify pathogens 2Researcher using next-generation sequencing to rapidly identify pathogens 3How sweet it is 2How sweet it is 3Wyss Institute's technology translation engine launches 'Organs-on-Chips' company 2Wyss Institute's technology translation engine launches 'Organs-on-Chips' company 3
... pays to be rare—think of a one-of-a-kind diamond, a ... , Now, new research suggests that being rare has ... University of Toronto Mississauga who in the 1980s discovered ... fruit flies, has identified the benefit of rarity in ...
... the La Jolla Institute for Allergy & Immunology have ... be reduced ?and in some cases eliminated ?through the ... the immune system. The research team’s findings, based ... implications for other chronic virus infections, such as hepatitis ...
... how ocean circulation is working in the current that ... from underwater volcanoes. The details are published in Nature ... Garabato of the National Oceanography Centre, Southampton (formerly based ... 'short-circuit' in the circulation of the world's oceans that ...
Cached Biology News:Survival of the rarest: Fruit flies shed light on the evolution of behavior 2LIAI scientists make important finding on cytomegalovirus transmission 2'Short-circuit' found in ocean circulation 2
(Date:7/29/2014)... (PRWEB) July 29, 2014 EXpressLO LLC, ... lift out specimen preparation solutions, has been granted patent ... for specimen manipulation methods incorporating a unique specimen carrier ... This is the second company patent for EXpressLO LLC ... , These complementary patents extend EXpressLO’s portfolio ...
(Date:7/28/2014)... July 28, 2014 The Workgroup for ... on the use of health IT to create efficiencies ... Plan Identifier (HPID) Workgroup has developed an issue ... Plan and Payer?” The HPID Workgroup, a part of ... the Centers for Medicare and Medicaid Services (CMS) to ...
(Date:7/28/2014)... , July 28, 2014 Research ... "Global Synthetic Biology Market 2014-2018" report to ... The term synthetic biology covers the designing ... organisms as well as the redesigning of natural biological ... considered to be a form of extreme genetic engineering ...
(Date:7/28/2014)... Boston, MA (PRWEB) July 28, 2014 ... with two researchers to further develop potential treatments for ... brain tumor, in combination with their patented vaccine platform, ... and Duke University, are based on the work of ... of Neurosurgery at The Preston Robert Tisch Brain Tumor ...
Breaking Biology Technology:EXpressLO LLC Granted Second U.S. Patent for Innovative Specimen Preparation Methods 2WEDI’s HPID Workgroup Announces Release of Issue Brief: “What is the Difference Between a Health Plan and Payer?” 2Global Synthetic Biology Market 2014-2018 2String of Collaborations Launch Immunomic Therapeutics’ Brain Tumor Program Pipeline 2String of Collaborations Launch Immunomic Therapeutics’ Brain Tumor Program Pipeline 3String of Collaborations Launch Immunomic Therapeutics’ Brain Tumor Program Pipeline 4
... one of six states to receive a $50,000 grant ... network further into the Internet age. , ,Wisconsin's grant ... of Justice Assistance, which houses the Wisconsin Justice ... maintaining, promoting and coordinating automated justice information systems. , ...
... the learning acquired in the program but rather the blue-chip roster ... mythology goes, you can call on a fellow alum to help ... will be of value once again. , ,Though I can't say ... can attest to the power of alumni connections. , ,While I'm ...
... of health-care and business technology, announced a seven-year contract with ... Information System (MMIS). The new system is expected to be ... contracts EDS to implement its InterChange health system on the ... Services . The contract is worth approximately $189 million and ...
Cached Biology Technology:State receives grant for justice information sharing 2Pay attention to your alumni connections when job hunting 2Pay attention to your alumni connections when job hunting 3Pay attention to your alumni connections when job hunting 4State picks long-time vendor for $189m Medicaid information system 2
... (GST) is commonly used as a fusion ... (1). The GSTTag sequence has been reported ... cases the solubility of its fusion partners. ... form, GSTTag fusion proteins can be purified ...
... applications for the use of small interfering ... via the RNA interference (RNAi) pathway have ... molecular biology fields. siRNA for experimental use ... or enzymatically, and then transfected into the ...
... unique collision reaction interface (CRI) system*, ... troublesome spectroscopic interferences. The result is ... the worry of complex multipole or ... And, by coupling autotuning of all ...
Acetylcholinesterase (human brain, AChE)...
Biology Products: