Navigation Links
UNC scientists turn human skin cells into insulin-producing cells
Date:9/17/2008

CHAPEL HILL Researchers at the University of North Carolina at Chapel Hill School of Medicine have transformed cells from human skin into cells that produce insulin, the hormone used to treat diabetes.

The breakthrough may one day lead to new treatments or even a cure for the millions of people affected by the disease, researchers say.

The approach involves reprogramming skin cells into pluripotent stem cells, or cells that can give rise to any other fetal or adult cell type, and then inducing them to differentiate, or transform, into cells that perform a particular function in this case, secreting insulin.

Several recent studies have shown that cells can be returned to pluripotent state using "defined factors" (specific proteins that control which genes are active in a cell), a technique pioneered by Dr. Shinya Yamanaka, a professor at Kyoto University in Japan.

However, the UNC study is the first to demonstrate that cells reprogrammed in this way can be coaxed to differentiate into insulin-secreting cells. Results of the study are published online in the Journal of Biological Chemistry.

"Not only have we shown that we can reprogram skin cells, but we have also demonstrated that these reprogrammed cells can be differentiated into insulin-producing cells which hold great therapeutic potential for diabetes," said study lead author Yi Zhang, Ph.D., Howard Hughes Medical Institute investigator, professor of biochemistry and biophysics at UNC and member of the Lineberger Comprehensive Cancer Center.

"Of course, there are many years of additional studies that are required first, but this study provides hope for a cure for all patients with diabetes," said John Buse, M.D., Ph.D., president of the American Diabetes Association and professor and chief of the endocrinology division in the UNC School of Medicine's department of medicine.

About 24 million Americans suffer from diabetes, a dise
'/>"/>

Contact: Les Lang
llang@med.unc.edu
919-966-9366
University of North Carolina School of Medicine
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Scientists isolate cancer stem cells
2. Scientists form alliance to develop nanotoxicology protocols
3. Scientists point to forests for carbon storage solutions
4. US Air Force technology helps scientists understand plant root function
5. Best way to treat malaria: Avoid using same drug for everyone, scientists say
6. Scientists uncover Ebola cell-invasion strategy
7. Scientists use remote satellite imaging to predict outbreaks of infectious disease
8. Scientists develop new method to investigate origin of life
9. Caltech scientists create DNA tubes with programmable sizes for nanoscale manufacturing
10. Indiana U researchers launch social networking and research management tool for scientists
11. CSHL scientists identify new drug target against virulent type of breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UNC scientists turn human skin cells into insulin-producing cells
(Date:2/9/2015)... , Feb. 9, 2015  Lintec of America ... methods for carbon nanotube (CNT) macrostructures, including sheets, yarns ... Dallas (UTD). Leveraging the vast industrial resources ... Tokyo, Japan , Lintec of America is forming ... Richardson, TX , focusing on scaling up the ...
(Date:2/5/2015)... 5, 2015  Marken is starting its 35 th ... launched a new marketing campaign to solidify its place ... new campaign focuses on First as a ... The first headline in the series, ... with its client,s priorities. Marken recognizes the need to ...
(Date:2/5/2015)... OXFORD, Conn. , Jan. 26, 2015 NXT-ID, ... or the "Company"), a biometric authentication company focused on ... a new corporate website ( http://www.nxt-id.com/ ) as part ... Wocket™ smart wallet. The Company launched its new consumer ... Gino Pereira , CEO of NXT-ID said, "Our ...
Breaking Biology News(10 mins):Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 2Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 3Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 4Marken Launches New Patient-Centric Campaign 2NXT-ID, Inc. Launches New Corporate Website As Part Of Ongoing 2015 Branding Initiatives For Wocket Smart Wallet 2NXT-ID, Inc. Launches New Corporate Website As Part Of Ongoing 2015 Branding Initiatives For Wocket Smart Wallet 3
... in cells that may help to kill tumors with heat. ... by a combination of heat and an anti-cancer drug that ... ability of heat to switch off essential survival mechanisms in ... underlying principles are still unclear. In a recent publication ...
... with large, lace-like wings that live in a wide variety ... but the larvae are ferocious predators of other insects, frequently ... after killing them using their enormous, sucking tube-like jaws. ... in the genus Semachrysa is described from the ...
... that the extremely hot, dry and windy conditions on Black ... rolls, -similar to streamers of wind flowing through the air ... the first of its kind to produce such detailed, high-resolution ... for future fire management and warning systems. The work ...
Cached Biology News:Unusual weather events identified during the Black Saturday bushfires 2
(Date:3/3/2015)... -- Thingee Corporation, a software development company for the Life ... Adoption: Making Reps, Lives Easier" during the 2015 Synergistix ...  in Deerfield Beach, Florida , taking ... to learn how technology can help them do their ... audience for the Thingee presentation. ...
(Date:3/3/2015)... (PRWEB) March 03, 2015 Genedata, ... drug discovery and life science research, today announced ... (TM) enterprise platform for use at Pfizer biopharma ... Europe. Genedata is supporting Pfizer’s global deployment and ... (GBT), Centers for Therapeutic Innovation (CTI), and Pharmaceutical ...
(Date:3/3/2015)... FRANCISCO , March 3, 2015  Johnson & ... @ South San Francisco (JLABS @SSF), ... Boulevard, South San Francisco, Calif. ... accommodate up to 50 startups from across the healthcare ... health.  The first resident startups have ...
(Date:3/3/2015)... Nev. , March 3, 2015  PDL BioPharma, ... ) today announced that the third of three shareholder ... dismissed without prejudice. On February 2, 2015, ... last September on behalf of a putative class of ... Inc., et al., No. 2:14-CV-01526-APG-NJK (D. Nev.), was voluntarily ...
Breaking Biology Technology:Thingee to present at 11th Annual Synergistix Users Conference 2Genedata Biologics Licensed by Pfizer Inc. 2Genedata Biologics Licensed by Pfizer Inc. 3Johnson & Johnson Innovation Opens JLABS @South San Francisco and Announces First Five Resident Startups 2Johnson & Johnson Innovation Opens JLABS @South San Francisco and Announces First Five Resident Startups 3Johnson & Johnson Innovation Opens JLABS @South San Francisco and Announces First Five Resident Startups 4Johnson & Johnson Innovation Opens JLABS @South San Francisco and Announces First Five Resident Startups 5PDL BioPharma Announces Dismissal of Third and Final Shareholder Lawsuit 2
... Stallergenes,S.A. officially inaugurates its new pharmaceutical production ... comply with the most stringent EMEA (European Medicines,Agency) ... this unit will,produce desensitisation treatments for all markets, ... worth more than 20 million euros will incorporate ...
... Sept. 10 Signalife, Inc. (Amex:,SGN) announced that the company,s ... stock to be effected in the form of a,reverse stock ... on September,19, 2008, which will be the record date and ... time of such reverse stock split, all,outstanding shares of Signalife ...
... - Abstracts 185 and 1112, Sanofi-aventis, ... from,two randomized clinical studies presented at the European ... Meeting demonstrating that the,"basal plus" insulin strategy with ... insulin) and APIDRA(R) once daily,(prandial insulin) (insulin glulisine ...
Cached Biology Technology:Stallergenes Inaugurates the Biggest Pharmaceutical Allergen Production Unit in the World 2Signalife Announces Reverse Stock Split, Preferred Stock Dividend and $5 Million Investment 2Signalife Announces Reverse Stock Split, Preferred Stock Dividend and $5 Million Investment 3Signalife Announces Reverse Stock Split, Preferred Stock Dividend and $5 Million Investment 4Signalife Announces Reverse Stock Split, Preferred Stock Dividend and $5 Million Investment 5Signalife Announces Reverse Stock Split, Preferred Stock Dividend and $5 Million Investment 6Sanofi Aventis : New Study Results Support the "Basal Plus" Strategy With LANTUS(R) and APIDRA(R) to Improve Blood Sugar Control in Patients With Type 2 Diabetes 2Sanofi Aventis : New Study Results Support the "Basal Plus" Strategy With LANTUS(R) and APIDRA(R) to Improve Blood Sugar Control in Patients With Type 2 Diabetes 3Sanofi Aventis : New Study Results Support the "Basal Plus" Strategy With LANTUS(R) and APIDRA(R) to Improve Blood Sugar Control in Patients With Type 2 Diabetes 4
Antibodies were affinity purified using epitopes specific to Alpha4 immobilized on solid support....
Prepared in distilled water....
in vitro Translation, Accessory Products...
... Origami host strains are K-12 derivatives ... reductase (trxB) and glutathione reductase (gor) genes, ... the cytoplasm. Studies have shown that expression ... than in another host even though overall ...
Biology Products: