Navigation Links
UNC scientists pinpoint link between light signal and circadian rhythms
Date:12/29/2010

Chapel Hill, NC In a new paper published this week in the Proceedings of the National Academy of Sciences, Aziz Sancar, MD, PhD, the Sarah Graham Kenan Professor of Biochemistry and Biophysics in the UNC School of Medicine, and his colleagues have taken an important step in understanding the underlying molecular signals that influence a broad array of biological processes ranging from the sleep-wake cycle to cancer growth and development.

Scientists who work in this field, known as chronobiology, have identified the genes that direct circadian rhythms in people, mice, fruit flies, fungi and several other organisms. However, the mechanisms by which those genes interact with light in the organism's environment have not been well understood.

Circadian rhythms are the physical, mental and behavioral changes that follow the earth's 24 hour cycle, responding primarily to light and darkness in an organism's environment.

About 15 years ago, Sancar discovered a human protein called cryptochrome which acts as a core component of the molecular clock in mammals. The protein is also found in fruit flies, other insects, and plants.

"Cryptochrome 'resets' the circadian clock, but we were not sure how it worked," said Sancar, who is also a member of UNC Lineberger Comprehensive Cancer Center.

Using fruit flies (Drosophilia melanogaster), the team purified cryptochrome and developed a biochemical test that shows when and how the protein transmits signals.

"We can now detect the protein at work. When we expose cryptochrome to blue light in fruit flies, a millisecond of light exposure has a half-life during which we can examine the mechanism in the laboratory," said Sancar. "We can follow the molecular signals after light exposure and have a reliable model to test various hypotheses about how light interacts with the circadian systems we know are so important to biological processes."

The research may be useful to scientists who study the circadian clock's relationship to sleep disorders, jet lag, cancer, bipolar disorder, depression and other diseases.


'/>"/>

Contact: Ellen de Graffenreid
edegraff@med.unc.edu
919-962-3405
University of North Carolina School of Medicine
Source:Eurekalert

Related biology news :

1. Scripps Research scientists identify key interaction in hepatitis C virus
2. SU scientists find that in the evolutionary mating game, brawn and stealth rule
3. CSHL scientists show in unprecedented detail how cortical nerve cells form synapses with neighbors
4. Damon Runyon Cancer Research Foundation awards breakthrough scientists
5. UCSB scientists demonstrate biomagnification of nanomaterials in simple food chain
6. Scientists and physicians use genetic sequencing to identify and treat unknown disease
7. Scientists decipher 3 billion-year-old genomic fossils
8. Scripps Research scientists show prions mutate and adapt to host environment
9. Scientists discover powerful biomarker panel for the early detection of breast cancer
10. Scientists identify the largest network of protein interactions related to Alzheimers disease
11. Polar bears: On thin ice? Extinction can be averted, scientists say
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/15/2016)... New York , June 15, 2016 /PRNewswire/ ... a new market report titled "Gesture Recognition Market by ... and Forecast, 2016 - 2024". According to the report, ... USD 11.60 billion in 2015 and is estimated ... reach USD 48.56 billion by 2024.  ...
(Date:6/2/2016)... , June 2, 2016 The Department ... has awarded the 44 million US Dollar project, for the ... Vehicle Plates including Personalization, Enrolment, and IT Infrastructure , ... in the production and implementation of Identity Management Solutions. Numerous ... however Decatur was selected for the ...
(Date:5/20/2016)... 2016  VoiceIt is excited to announce its ... By working together, VoiceIt and VoicePass will ... VoicePass take slightly different approaches to voice biometrics, ... and usability. ... partnership. "This marketing and technology partnership ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... ... announce the launch of their brand, UP4™ Probiotics, into Target stores nationwide. The ... is proud to add Target to its list of well-respected retailers. This list ...
(Date:6/23/2016)... 23, 2016 /PRNewswire/ - FACIT has announced the ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" or ... of a portfolio of first-in-class WDR5 inhibitors for ... as WDR5 represent an exciting class of therapies, ... medicine for cancer patients. Substantial advances have been ...
(Date:6/23/2016)... 2016 Houston Methodist Willowbrook Hospital has ... Association to serve as their official health care ... Willowbrook will provide sponsorship support, athletic training services, ... coaches, volunteers, athletes and families. "We ... Association and to bring Houston Methodist quality services ...
(Date:6/23/2016)... -- The Prostate Cancer Foundation (PCF) is pleased to announce 24 new ... prostate cancer. Members of the Class of 2016 were selected from a pool ... Read More About the Class of 2016 PCF Young Investigators ... ... ...
Breaking Biology Technology: