Navigation Links
UNC scientists identify cellular communicators for cancer virus
Date:11/8/2010

Chapel Hill - A new discovery by UNC scientists describes how cells infected by the Epstein-Barr virus (EBV) produce small vesicles or sacs called exosomes, changing their cellular "cargo" of proteins and RNA. This altered exosome enters cells and can change the growth of recipient cells from benign to cancer-producing.

In this way, virus-infected cells can have wide-ranging effects and potentially manipulate other cells throughout the body. The findings are reported in the November 8, 2010 early online edition of the Proceedings of the National Academy of Sciences.

Nancy Raab-Traub, PhD, professor of microbiology and Immunology, said, "Exosomes may be the Trojan Horse through which EBV gains control of cells that are not even infected. Importantly, the production of exosomes may provide a new therapeutic target that can be blocked to reduce cancer growth." Raab-Traub is a Sarah Graham Kenan Professor and member of UNC Lineberger Comprehensive Cancer Center.

Epstein-Barr Virus (EBV) is perhaps the world's most successful virus as almost everyone is infected with it for life. EBV cannot be eliminated by the immune system and is constantly secreted into saliva where it is effectively transmitted. Infection with the virus rarely causes disease; however, EBV is found in several major cancers, including lymphoma and cancer of the nose and throat, where its proteins hijack the cell's growth regulatory mechanisms to induce uncontrolled cell growth characteristic of cancer.

Through exosomes, a protein called latent membrane protein 1, that is considered the EBV oncogene, can be delivered to uninfected cells. Significantly, EBV also changes the entire contents of the exosomes to deliver cellular proteins that are also activated in cancers. This surprising finding reveals that one infected cell can have wide-ranging effects and induce the unchecked growth of neighboring cells.

The immune system is constantly on guard
'/>"/>

Contact: Dianne Shaw
dgs@med.unc.edu
919-966-5905
University of North Carolina School of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists discover how the songbirds brain controls timing during singing
2. Scientists pinpoint key defense against parasite infection
3. McMaster scientists turn skin into blood
4. Scientists at IRB Barcelona discover a new protein critical for mitochondria
5. Scientists find that evergreen agriculture boosts crop yields
6. VIMS scientists help solve mystery of alien pod
7. Speed installation of system to monitor vital signs of global ocean, scientists urge
8. Media alert: Agronomists, crop and soil scientists to convene in Long Beach
9. Scientists describe new approach for identifying genetic markers for common diseases
10. Rictor protein offers scientists a new molecular target for cancer therapies
11. USDA scientists helping keep in-demand smoked salmon safe to eat
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... have shown that excessive iron is closely ... Previous studies from Chunyan Guo and co-workers ... shown that baicalin prevented iron accumulation after ... 1 expression, and increased ferroportin 1 expression ... disease rats. However, the relationship between iron ...
(Date:8/27/2014)... As of seven hours ago the Happy Camp Complex ... Northern California, the July complex had consumed 35,530 as ... seventeen fires on the Happy Camp Ranger District of ... the area on August 11, 2014. All but three ... following is a list of contained fires and their ...
(Date:8/27/2014)... Researchers from North Carolina State University have found that century-old ... affect a common insect pest that can weaken and kill ... studies found that scale insect populations increase on oak and ... that these pests may also increase with global warming," says ... lead author of a paper on the work. , "More ...
Breaking Biology News(10 mins):Happy Camp and July Fire Complexes in California 2Museum specimens, modern cities show how an insect pest will respond to climate change 2
... cells are encased within a protective lipid membrane. The ... that transport nutrients, ions, and water into and out ... recognize each other in the body, and make the ... mapped out nearly all of the membrane proteins in ...
... must be standardized among laboratories and across platforms around ... exploration, an Oregon Health & Science University researcher says. ... gene chips, risk having their research results called into ... the OHSU School of Medicine. , Spencer, director of ...
... development requires billions of neurons to migrate to the appropriate ... connect to other nerve cells in an intricate network. Growth ... for steering axons in the right direction, guided by a ... way. Some signals lure the axons to extend and grow ...
Cached Biology News:Study: 'homemade' gene expression technology unreliable 2Study: 'homemade' gene expression technology unreliable 3Cerebral navigation: How do nerve fibers know what direction to grow in? 2
(Date:8/27/2014)... OR (PRWEB) August 27, 2014 According ... “Consolidation continues to reshape the look and feel of ... Consumer demand for higher-quality ingredients will push for more ... American market have experienced strong market growth in the ... attributes in their food and cosmetics to fit a ...
(Date:8/26/2014)... the thinnest-possible semiconductor, a new class of nanoscale ... , The University of Washington researchers have demonstrated ... be connected in an atomically seamless fashion known ... basis for next-generation flexible and transparent computing, better ... "Heterojunctions are fundamental elements of electronic and photonic ...
(Date:8/26/2014)... MA (PRWEB) August 26, 2014 The ... Faces of ALS (YFALS) community issued the following statement ... movement bringing awareness and driving new funding specifically for ... bucket of water and some ice would raise all ... together with our families, and on behalf of the ...
(Date:8/26/2014)... An analysis by Replikins, Ltd. of Pubmed ... strains in Pubmed, has revealed extensive conservation and sharing ... and sharing of specific Replikin gene structures has permitted ... it did for the H5N1 influenza vaccine and the ... found to be effective (1,2). This ...
Breaking Biology Technology:Daring to be Different Raw Materials & Ingredient Supply Shortage Fuels Vital Force™ Technology New Ingredient Enhancements 2Daring to be Different Raw Materials & Ingredient Supply Shortage Fuels Vital Force™ Technology New Ingredient Enhancements 3Scientists craft atomically seamless, thinnest-possible semiconductor junctions 2ALS TDI’s Young Faces of ALS Ambassadors Thank You for Accepting the Ice Bucket Challenge to End ALS 2ALS TDI’s Young Faces of ALS Ambassadors Thank You for Accepting the Ice Bucket Challenge to End ALS 3ALS TDI’s Young Faces of ALS Ambassadors Thank You for Accepting the Ice Bucket Challenge to End ALS 4
... April 15 ,BioHorizons, Inc. ("BioHorizons") announced today the ... ("ILS"), first announced on January,30, 2008. Implant Logic ... Boggan, CEO of BioHorizons, commented, "We are excited,to ... Implant Placement,planning software and CAD/CAM surgical guides. This ...
... Pain-Management Market ... ... Inc. (NYSE: AOB ), a leading marketer, distributor and,manufacturer ... Company, Inc. (OTC Bulletin Board: CAXG) ("China,Aoxing"), a China-based pharmaceutical ...
... Designs Comforting Environment for Patients and Families, ... Medical,Center celebrates the opening of two new health ... treatment options for,life-threatening illnesses and to offer health ... seamless delivery of screening and,diagnostic procedures, all in ...
Cached Biology Technology:BioHorizons Announces the Purchase of Implant Logic Systems 2American Oriental Bioengineering and China Aoxing Pharmaceutical Enter Into Strategic Alliance 2American Oriental Bioengineering and China Aoxing Pharmaceutical Enter Into Strategic Alliance 3American Oriental Bioengineering and China Aoxing Pharmaceutical Enter Into Strategic Alliance 4Alta Bates Summit Medical Center Opens Two Warm, Supportive Patient Centers: Carol Ann Read Breast Health Center and Family Resource Center 2Alta Bates Summit Medical Center Opens Two Warm, Supportive Patient Centers: Carol Ann Read Breast Health Center and Family Resource Center 3
Anti-gamma Glutamyl Transferase (gammaGT) Host: mouse monoclonal Species Reactivity: human Applications: WB, IP, FC Storage: 4C...
... Goat polyclonal to Cholesterol Oxidase ... / Specificity Cross-reacts with bacteria. Not ... Information Cholesterol oxidases exist as both ... are implicated in bacterial pathogenesis. In addition, ...
Goat polyclonal to XAGE1 ( Abpromise for all tested applications). Antigen: Synthetic peptide: CGFGFRRQGEDNT, corresponding to C terminal amino acids 149-160 of Human XAGE1 Entrez Gene ID: 9...
MDMA Mouse Monoclonal Antibody (Clone 3G8)...
Biology Products: