Navigation Links
UNC researchers show how cancer cells may respond to mechanical force
Date:4/9/2014

cell surface and the cytoskeleton surrounding the nucleus and other organelles.

"We normally think of cells responding to mechanical forces at their periphery," Burridge said. "This is the first time, I think, that someone has shown that an isolated organelle can respond to mechanical force. I think it is actually a significant finding in the big picture of biology."

In the Journal of Immunology paper, lead author graduate student Elizabeth Lessey-Morillon examined the ways in which the cells lining our blood vessels stiffen and relax to allow immune system cells to pass out of the bloodstream into surrounding tissue. Cancer researchers have a particular interest in this process, as metastasizing tumor cells may use the same mechanisms to migrate through the body.

"We think metastasizing cells may essentially mimic what white blood cells do," said Burridge.

Using magnetic beads attached to the endothelial cells that line blood vessels, Lessey-Morillon discovered that applying force to the cells caused them to stiffen, opening gaps between the cells through which the white blood cells could pass. The response activated a pathway mediated by the proteins RhoA and LARG.

When she blocked the pathway, the cell stiffening response slowed. Because the pathway may also play a role in cancer metastasis, Burridge said the response could indicate that this pathway could be a viable target for future therapies.

"We think this response would be true also for tumor cells moving over the surface. They wouldn't be as competent in passing through the endothelial wall," said Burridge.


'/>"/>

Contact: William Davis
william_davis@med.unc.edu
919-966-5906
University of North Carolina Health Care
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Dartmouth researchers identify potential therapeutic target for deadly brain cancer
2. Researchers find arid areas absorb unexpected amounts of atmospheric carbon
3. Researchers receive $1.14 million to study threats to honey bees
4. Swedish researchers show impact of long-term vitamin D insufficiency on fracture risk
5. Guelph researchers solve part of hagfish slime mystery
6. Researchers design trees that make it easier to produce paper
7. Researchers manipulate tiny objects with ultrasound
8. UCSB researchers create first regional Ocean Health Index
9. Researchers identify how zinc regulates a key enzyme involved in cell death
10. Researchers reveal a new pathway through the sodium pump
11. Researchers uncover secrets of a mollusks unique bioceramic armor
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UNC researchers show how cancer cells may respond to mechanical force
(Date:8/5/2015)... According to a new market research report, ... (BFSI, Airport, IT & Telecom, Utilities, Education, Defense & ... published by MarketsandMarkets, defines and segments the Physical Identity ... global PIAM Market is estimated to grow from $272.2 ... a CAGR of 14.9 % from 2014 to 2019. ...
(Date:8/5/2015)... MOUNTAIN VIEW, Calif. , Aug. 5, 2015 /PRNewswire/ ... it exhibits continuous growth in applications, penetration into newer ... year after year. The global biosensors space has seen ... having exited the market so far. (Photo ... from Frost & Sullivan, Analysis of the Global ...
(Date:8/4/2015)... N.Y., Aug. 4, 2015  AMRI (NASDAQ: AMRI ) today ... 30, 2015. Highlights: , Second quarter contract ... from 2014 , Adjusted contract margins of ... of $0.22, including a $0.05 decrease in EPS from royalties in ... $16 million "We are very pleased to present ...
Breaking Biology News(10 mins):Physical Identity and Access Management Market Worth $546.2 Million by 2019 2Physical Identity and Access Management Market Worth $546.2 Million by 2019 3Physical Identity and Access Management Market Worth $546.2 Million by 2019 4Innovative Biosensors Incite Use in Non-Traditional Applications 2Innovative Biosensors Incite Use in Non-Traditional Applications 3Innovative Biosensors Incite Use in Non-Traditional Applications 4AMRI Announces Second Quarter 2015 Results 2AMRI Announces Second Quarter 2015 Results 3AMRI Announces Second Quarter 2015 Results 4AMRI Announces Second Quarter 2015 Results 5AMRI Announces Second Quarter 2015 Results 6AMRI Announces Second Quarter 2015 Results 7AMRI Announces Second Quarter 2015 Results 8AMRI Announces Second Quarter 2015 Results 9AMRI Announces Second Quarter 2015 Results 10AMRI Announces Second Quarter 2015 Results 11AMRI Announces Second Quarter 2015 Results 12AMRI Announces Second Quarter 2015 Results 13AMRI Announces Second Quarter 2015 Results 14AMRI Announces Second Quarter 2015 Results 15AMRI Announces Second Quarter 2015 Results 16AMRI Announces Second Quarter 2015 Results 17AMRI Announces Second Quarter 2015 Results 18AMRI Announces Second Quarter 2015 Results 19AMRI Announces Second Quarter 2015 Results 20AMRI Announces Second Quarter 2015 Results 21AMRI Announces Second Quarter 2015 Results 22AMRI Announces Second Quarter 2015 Results 23AMRI Announces Second Quarter 2015 Results 24
... the degenerative inflammatory bone disease, may be a sign of ... the Annals of the Rheumatic Diseases. , The authors base ... between 30 and 79. Most of them were female twins. ... to check for signs of osteoarthritis and a blood sample ...
... a chemist by training, first ventured into nerve regeneration ... would have considered him crazy. , His idea was ... by neurotransmitters (chemical messengers) to communicate between the brain ... neurotransmitters into the material used to repair a broken ...
... Manchester researchers are recruiting people with backache caused by ... first ever study to discover if therapeutic ultrasound can ... team at the University's Centre for Rehabilitation Science need ... less than 12 weeks, are not pregnant and have ...
Cached Biology News:Osteoarthritis may be sign of faster 'biological ageing' 2Dopamine used to prompt nerve tissue to regrow 2
(Date:8/30/2015)... England , August 31, 2015 ...   einer Frau   für chirurgische   Behandlung     ... von 7-90   werden für eine   verheerende ... 1200 Frauen behandeln und die Anzahl ausgebildeter Chirurgen in ... Astellas gab heute bekannt, dass  Action on Fistula ...
(Date:8/28/2015)... ... August 28, 2015 , ... Pittcon is pleased to announce ... session on chemical spectroscopic imaging at JASIS 2015 (Japan Analytical & Scientific Instruments ... and scientific instruments show which will be held at International Conference Hall in ...
(Date:8/27/2015)... CA (PRWEB) , ... August 27, 2015 , ... ... unique opportunity for venture capital funds, investment firms and animal health companies to ... Forum have raised $160 million. Several have also received licensing agreements or distribution ...
(Date:8/27/2015)... The National Necrotizing Fasciitis Foundation ... by doctors at Vanderbilt University Hospital in ... and Dr. John Crew , director of the ... Center in Daly City, CA. ... pioneered by Dr. Crew, that had previously saved the ...
Breaking Biology Technology:Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 2Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 3Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 4Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 5U.S. Symposium on Imaging Organized by Pittcon’s Program Chairman Chuck Gardner 2U.S. Symposium on Imaging Organized by Pittcon’s Program Chairman Chuck Gardner 3VetStem Biopharma, Inc. Among Seventeen Companies Selected to Present at the KC Animal Health Investment Forum on September 1st 2015 2VetStem Biopharma, Inc. Among Seventeen Companies Selected to Present at the KC Animal Health Investment Forum on September 1st 2015 3Patient's Life and Eyes Saved from Gruesome Flesh-Eating Infection Consuming Her Face 2Patient's Life and Eyes Saved from Gruesome Flesh-Eating Infection Consuming Her Face 3
... Trial Meets Primary and Key Secondary Endpoints,NEW YORK, March ... results from the ITI-007 Phase II trial in patients ... ITI-007 significantly and dose-dependently increased slow wave sleep and ... measured by polysomnography (PSG), meeting the prespecified primary and ...
... Key Regulatory MilestoneLONDON, March 10 Monsanto,s historic ... biotechnology has contributed to a 24 percent compound annual ... since 2001. This is one of the key ... will tell investors today as part of a presentation ...
... been known for its world-record-breaking carbon nanotubes. Now ... new uses by spinning carbon nanotubes (CNTs) into ... Breakthroughs Without Broken Threads , Taking ... carbon nanotubes of world-record breaking lengths, researchers Vesselin ...
Cached Biology Technology:Intra-Cellular Therapies Reports Positive Final Results of a Phase II Clinical Trial with ITI-007 in Patients with Sleep Maintenance Insomnia 2Intra-Cellular Therapies Reports Positive Final Results of a Phase II Clinical Trial with ITI-007 in Patients with Sleep Maintenance Insomnia 3Intra-Cellular Therapies Reports Positive Final Results of a Phase II Clinical Trial with ITI-007 in Patients with Sleep Maintenance Insomnia 4Intra-Cellular Therapies Reports Positive Final Results of a Phase II Clinical Trial with ITI-007 in Patients with Sleep Maintenance Insomnia 5Intra-Cellular Therapies Reports Positive Final Results of a Phase II Clinical Trial with ITI-007 in Patients with Sleep Maintenance Insomnia 6Intra-Cellular Therapies Reports Positive Final Results of a Phase II Clinical Trial with ITI-007 in Patients with Sleep Maintenance Insomnia 7Monsanto's Historic R&D Investment has Contributed to Mid-20s Gross Profit Growth for Its Seeds and Genomics Segment 2Monsanto's Historic R&D Investment has Contributed to Mid-20s Gross Profit Growth for Its Seeds and Genomics Segment 3Spinning carbon nanotubes spawns new wireless applications 2
Purified anti-eIF-4E...
Peptide-affinity Purified Polyclonal Antibody to SMAD7 Peptide with sequence SSCPCWLEVIFNSR, from C Terminus of the protein sequence according to NP_005895....
Purified anti-PXR...
Polyclonal Antibody to PRG3...
Biology Products: