Navigation Links
UNC Lineberger scientists lead definition of key lung cancer genome
Date:9/9/2012

In the September 9, 2012 early online edition of Nature, scientists with The Cancer Genome Atlas (TCGA) report that they have characterized the lung squamous cell carcinoma genome.

Squamous cell carcinoma is the second most common form of lung cancer, a disease that kills more Americans than any other type of cancer.

The national team of scientists examined tumor samples from 178 patients with untreated lung squamous cell carcinoma and completed genetic analysis of the tumors, work that paves the way for developing better, more targeted therapies to treat the cancer.

Neil Hayes, MD, MPH, a UNC investigator with TCGA, explains, "The work confirms the prevalence of commonly known cancer genes such as p53 and p16 in LSCC: alteration of p53 in patients is approaching 100 percent while 70-80 percent of patients have clear alterations of p16. Our report documents a long list of mutations that could be targeted therapeutically, some even now with drugs currently available or in clinical trials."

Dr. Hayes served as co-chair of the manuscript writing committee for the paper. With Matthew Wilkerson, PhD, he served as genomic analysis leader and mRNA sequence analysis. Dr. Hayes is an associate professor of medicine.

He says, "UNC scientists generated all of the microarray and sequencing data on RNA and provided technical expertise in analyzing it. Analyzing gene expression data is very challenging, and UNC brought a large number of collaborators in computer science, statistics, and genetics to help.

"We and all TCGA scientists worked closely together on all aspects of this work," he explains. "Participating institutions provided high-quality tumor samples for the analysis. The study required a wide range of technical expertise to perform all the assays, and no one center could have done it all. "

Putting the study in a scientific context, he explains, "This is like a lot of great science advances. Think back to the late 1700s before it was widely known that many diseases were caused by infections. It's very hard to consider the idea of an antibiotic until you've thought of a germ. We have a disease that's caused by alterations in DNA. It's hard to think about therapies until you know what's wrong with the DNA. In the case of lung cancer, we've made a huge step forward in understanding what's wrong with the DNA of lung cancer."

Co-PI Charles Perou, PhD, says, "This, and other TCGA studies show the powers of a multi-institutional and multi-technological approach. For LSCC, we not only studied the tumor DNA, but also the tumor RNA, with the integration of these data types yielded far more information that either type alone. These data identified numerous new and old drug targets, which is setting the stage for the next generation of clinical trials for LSCC patients." Dr. Perou is the May Goldman Shaw Distinguished Professor of Molecular Oncology.

TCGA is a groundbreaking effort to sequence the entire genome of 20 individual cancers, involving scientists from around the world. UNC Lineberger was one of the original consortium members and will receive over $20 million in grants to fund the research, which extends across multiple types of cancer. TCGA is funded jointly by the National Cancer Institute and the National Human Genome Research Institute, both part of the National Institutes of Health.


'/>"/>
Contact: Dianne G. Shaw
dgs@med.unc.edu
919-966-7834
University of North Carolina Health Care
Source:Eurekalert

Related biology news :

1. University of Alberta medical scientists first in the world to look at structure of vital molecule
2. Scripps Florida scientists design molecule that reverses some fragile X syndrome defects
3. A*STAR scientists discover potential drug for deadly brain cancer
4. Singapore scientists find genes associated with glaucoma, a major cause of eye blindness
5. EARTH: Antarctic trees surprise scientists
6. Rice, MD Anderson scientists probe mystery of operon evolution
7. Coral scientists use new model to find where corals are most likely to survive climate change
8. Scientists call policy-makers to be scale-aware
9. Chinese scientists successfully crack the genome of diploid cotton
10. Scientists find oldest occurrence of arthropods preserved in amber
11. To cap or not to cap: Scientists find new RNA phenomenon that challenges dogma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/12/2016)... DALLAS , May 12, 2016 ... has just published the overview results from the Q1 ... of the recent wave was consumers, receptivity to a ... wearables data with a health insurance company. ... choose to share," says Michael LaColla , CEO ...
(Date:4/28/2016)... and BANGALORE, India , April 28, ... Systems, a product subsidiary of Infosys (NYSE: INFY ... announced a global partnership that will provide end ... use mobile banking and payment services.      (Logo: ... key innovation area for financial services, but it also plays ...
(Date:4/26/2016)... 27, 2016 Research and ... Biometrics Market 2016-2020"  report to their offering.  , ... The analysts forecast the global multimodal biometrics ... during the period 2016-2020.  Multimodal biometrics ... such as the healthcare, BFSI, transportation, automotive, and ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 2016  Blueprint Bio, a company dedicated to identifying, ... community, has closed its Series A funding round, according ... "We have received a commitment from Forentis Fund ... to meet our current goals," stated Matthew Nunez ... to complete validation on the current projects in our ...
(Date:6/23/2016)... ... June 23, 2016 , ... ClinCapture, the ... Convention Center and will showcase its product’s latest features from June 26 to ... a scientific poster on Disrupting Clinical Trials in The Cloud during the conference. ...
(Date:6/23/2016)... 22, 2016  Amgen (NASDAQ: AMGN ) ... QB3@953 life sciences incubator to accelerate the development ... laboratory space at QB3@953 was created to help high-potential ... for many early stage organizations - access to laboratory ... Amgen launched two "Amgen Golden Ticket" awards, providing each ...
(Date:6/22/2016)... DUBLIN , June 22, 2016 Research ... and Global Markets" report to their offering. ... $39.4 billion in 2014 from $29.3 billion in 2013. The market ... (CAGR) of 13.8% from 2015 to 2020, increasing from $50.6 billion ... and projected product forecasts during the forecast period (2015 to 2020) ...
Breaking Biology Technology: