Navigation Links
UNC Lineberger researchers develop new approach to identify 'drivers' of cancer

CHAPEL HILL, NC UNC Lineberger Comprehensive Cancer Center researchers have developed a new integrated approach to pinpoint the genetic "drivers" of cancer, uncovering eight genes that could be viable for targeted breast cancer therapy.

The study, published online August 24 in Nature Genetics, was authored by Michael Gatza, PhD, lead author and post-doctoral research associate; Grace Silva, graduate student; Joel Parker, PhD, director of bioinformatics, UNC Lineberger; Cheng Fan, research associate; and senior author Chuck Perou, PhD, professor of genetics and pathology.

These researchers studied a variety of cancer causing pathways, the step-by-step genetic alterations in which normal cells transition into cancerous cells, including the pathway that governs cancer cell growth rates. A high growth rate of cells, also known as cell proliferation, is recognized to be associated with poor prognosis for breast cancer patients.

Analyzing multiple types of genomic data, UNC Lineberger researchers were able to identify eight genes that were amplified on the genomic DNA level, and necessary for cell proliferation in luminal breast cancer, which is the most common sub-type of breast cancer.

"Using this new computational approach, we were able to take advantage of the rich data resources that exist and identify a number of new potential drug targets for a specific subset of breast cancer patients. This is an important step down the road towards more personalized medicine," said Perou.

In fact, one of the genes identified CPT1A is already a target for drug development in lymphoma and could potentially be tested for breast cancer patients as well. Drugs targeting CPT1A have been shown to inhibit human cancer cell line growth in vitro and in mouse models of lymphoma.

This analytical approach used to better understand the drivers of cancers includes a comprehensive and integrated analysis of multiple data types including gene expression data, somatic mutations, DNA copy number, and a functional genomics data set.

While the study focused on identifying genetic drivers for breast cancer, the approach could easily be applied to other tumors types as well. Lead author Mike Gatza added, "While we were able to pinpoint drivers for breast cancer, this approach can and will be applied to other tumor types in the future."


Contact: Katy Jones
University of North Carolina Health Care

Related biology news :

1. UNC Lineberger scientists lead definition of key lung cancer genome
2. Are you as old as what you eat? Researchers learn how to rejuvenate aging immune cells
3. BIDMC researchers named among the most influential scientific minds
4. Louisiana Tech University researchers use 3D printers to create custom medical implants
5. Researchers develop models to study polyelectrolytes, including DNA and RNA
6. Gene therapy protects mice from lethal heart condition, MU researchers find
7. Researchers block plant hormone
8. Researchers obtain key insights into how the internal body clock is tuned
9. Credit allocation among researchers determined by new algorithm
10. University of California brings researchers together for statewide autism summit
11. Climate relicts may help researchers understand climate change
Post Your Comments:
(Date:6/22/2016)... ANGELES , June 22, 2016 /PRNewswire/ ... identity management and verification solutions, has partnered ... edge software solutions for Visitor Management, Self-Service ... provides products that add functional enhancements ... partnership provides corporations and venues with an ...
(Date:6/21/2016)... VANCOUVER, British Columbia , June 21, 2016 ... been appointed to the new role of principal ... has been named the director of customer development. ... , NuData,s chief technical officer. The moves reflect ... development teams in response to high customer demand ...
(Date:6/16/2016)... , June 16, 2016 ... is expected to reach USD 1.83 billion by ... View Research, Inc. Technological proliferation and increasing demand ... are expected to drive the market growth. ... The development of advanced multimodal techniques ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... June 23, 2016 Houston Methodist Willowbrook ... Cy-Fair Sports Association to serve as their official ... Houston Methodist Willowbrook will provide sponsorship support, athletic ... with association coaches, volunteers, athletes and families. ... Cy-Fair Sports Association and to bring Houston Methodist ...
(Date:6/23/2016)... -- The Biodesign Challenge (BDC), a university competition that asks ... systems and biotechnology, announced its winning teams at the ... York City . The teams, chosen ... MoMA,s Celeste Bartos Theater during the daylong summit. Keynote ... of architecture and design, and Suzanne Lee , ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... STACS DNA ... Technical Leader at the Arkansas State Crime Laboratory, has joined STACS DNA as a ... STACS DNA team,” said Jocelyn Tremblay, President and COO of STACS DNA. “In further ...
(Date:6/23/2016)... , June 23, 2016  Blueprint Bio, a company ... to the medical community, has closed its Series A ... Nunez . "We have received a commitment ... capital we need to meet our current goals," stated ... us the runway to complete validation on the current ...
Breaking Biology Technology: