AMHERST, Mass. University of Massachusetts Amherst environmental toxicologist Edward Calabrese, whose career research shows that low doses of some chemicals and radiation are benign or even helpful, says he has uncovered evidence that one of the fathers of radiation genetics, Nobel Prize winner Hermann Muller, knowingly lied when he claimed in 1946 that there is no safe level of radiation exposure.
Calabrese's interpretation of this history is supported by letters and other materials he has retrieved, many from formerly classified files. He published key excerpts this month in Archives of Toxicology and Environmental and Molecular Mutagenesis.
Muller was awarded the 1946 Nobel Prize in medicine for his discovery that X-rays induce genetic mutations. This helped him call attention to his long-time concern over the dangers of atomic testing. Muller's intentions were good, Calabrese points out, but his decision not to mention key scientific evidence against his position has had a far-reaching impact on our approach to regulating radiation and chemical exposure.
Calabrese uncovered correspondence from November 1946 between Muller and Curt Stern at the University of Rochester about a major experiment that had recently evaluated fruit fly germ cell mutations in Stern's laboratory. It failed to support the linear dose-response model at low exposure levels, but in Muller's speech in Oslo a few weeks later he insisted there was "no escape from the conclusion that there is no threshold." To Calabrese, this amounts to deliberate concealment and he says Stern raised no objection.
Calabrese adds, "This isn't an academic debate, it's really practical, because all of our rules about chemical and low-level radiation are based on the premises that Muller and the National Academy of Sciences' (NAS) committee adopted at that time. Now, after all these years, it's very hard when people have been frightened to death by this dogma to
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| Contact: Janet Lathrop jlathrop@admin.umass.edu 413-545-0444 University of Massachusetts at Amherst Source:Eurekalert |
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