nsible for the transmission of genetic informationcan silence targeted genes. This process, RNAi offers astounding potential for understanding and manipulating the cellular basis of human disease, and is now the state-of-the-art method by which scientists can knock down the expression of specific genes to thus define the biological functions of those genes. Just as important has been the finding that RNAi is a normal process of genetic regulation that takes place during development, opening a new window on developmental gene regulation. RNAi has swept through laboratories around the world, changing the way many biomedical researchers work. Outside UMMS laboratories, companies at the forefront of pharmaceutical innovation are using RNAi technology to aid in their development of treatments for disease. At UMMS, researchers are taking full advantage of RNAi technology to speed investigation into a variety of diseases such as diabetes, cancer, ALS and HIV/AIDS.
Mello, a Howard Hughes Medical Institute Investigator, holds his BS in biochemistry from Brown University and his PhD in Cellular and Developmental Biology from Harvard University. He was a postdoctoral fellow at the Fred Hutchinson Cancer Research Center before coming to Worcester to join UMMS in 1995. He is also a 1995 Pew Scholar in the Biomedical Sciences. His work so inspired philanthropists John F. Jack Blais and wife Shelley that they contributed a $3 million gift in October 2003 to establish the Blais University Chair in Molecular Medicine to assist Mello in his future research endeavors. In addition to being honored with election to the AAAS and the National Academy of Science (Fire in 2004 and Mello in 2005), Mello and Fires discovery has garnered numerous honors, including the National Academy of Sciences Award in Molecular Biology in 2003. That same year, they were awarded the prestigious Wiley Prize in the Biomedical Sciences. Their RNAi finding was named the 2002 Breakthrough of the Ye
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