Navigation Links
UMass Medical School researchers receive $8.5M grant award to fight AIDS

WORCESTER, Mass. As the HIV/AIDS epidemic continues around the globe laying claim to more than 25 million lives and infecting over 39 million, researchers continue to search for both a cure and improved treatments for those suffering with this disease. Now the leading cause of death worldwide among 15 to 59 year olds, AIDS is a remarkably resilient adversary with the potent ability to evolve rapidly. This evolution dramatically complicates treatment, decreasing the effectiveness of existing drugs and necessitating the continual development of new therapeutics. University of Massachusetts Medical School Professor of Biochemistry & Molecular Pharmacology Celia A. Schiffer, PhD, is at the forefront of investigations to elucidate how HIV develops resistance to current drugs.

As a principal investigator of a National Institutes of Health Institute of General Medical Sciences Program Project Grant first awarded in 2001, Dr. Schiffer has comprised a stellar team of scientists from around the nation to develop HIV drugs that are less vulnerable to drug resistance. In recognition of the success of her efforts, Schiffer was recently awarded a full, five-year renewal of the project, Targeting Ensembles of Drug Resistant HIV-Protease. The renewal, totaling more than $8.5 million, will speed studies that seek a better understanding of inhibitor recognition and the development of new methodologies for designing inhibitors against HIV and other viruses and infections that have a propensity for acquiring drug resistance.

According to Terry R. Flotte, MD, executive deputy chancellor of UMMS and dean of the School of Medicine, the renewal reflects the NIHs confidence in Schiffers scientific aims. This work clearly illustrates how the advance of molecular biology can lead to direct benefit to patients. Dr. Schiffer's efforts to define exactly how HIV can become resistant to current drugs are vital to the development of better strategies to control HIV/AIDS.

While highly active antiretroviral treatment (HAART) including inhibitors that target HIV-1 proteasea protein that allows viral maturation through cutting and releasing key viral components in the immature virushas been remarkably successful in decreasing mortality, the emergence of mutations of HIV-1 that are resistant to current drug regimens is a critical factor in the clinical failure of antiviral therapy. With this renewed funding, Schiffer and colleagues will continue to address this challenge with a comprehensive approach that integrates clinical data, structural biology and biophysical chemistry, medical informatics and biostatistics, biochemistry and molecular virology, computational chemistry and computer-aided design, and synthetic and medicinal chemistry. The integrated program embraces two overarching goals: to clarify the role of compensatory mutations in HIV-1 protease in conferring drug resistance and to develop new HIV-1 protease inhibitors that are more robust against drug resistance.

The occurrence of drug resistance negatively impacts the lives of millions of patients by limiting the longevity of many of our most promising new drugs. Through this integrated approach, we look forward to contributing to the development of drugs that promise to be more effective against HIV. Importantly, the new strategies we develop may also reduce drug resistance in other quickly evolving diseases, including lung cancer and hepatitis C, Schiffer said.

To date, Schiffer and collaborators have made a number of advances. In 2004, for example, they were able to determine the crystal structures of many of the substratesthe sites HIV-1 protease cuts in the immature virus allowing viral maturationand to compare their shape with the existing drugs. They found that while the sequences of the sites that are cuts were different, they all fit within a similar space, which they dubbed the substrate envelope. Significantly, the investigators found that most of the currently used inhibitors protrude beyond the substrate envelope, and many mutations that cause drug resistance occur where the inhibitors protrude away from the substrates. Drug resistance occurs since mutations at these positions limit drug binding, but allow HIV-1 protease to continue to function by recognizing and cutting substrates, thereby permitting the virus to mature.

In 2006, expanding upon this work the investigators reported on a new strategy to reduce the probability of drug resistance, by designing and synthesizing novel inhibitors to fit within the substrate envelope. This strategy should greatly retard the occurrence of drug resistance as any mutation that would confer drug resistance would simultaneously impact substrate recognition, thereby preventing HIV protease from functioning. Thus inhibitors developed by this method should be more robust against resistance occurring. Confirming the validity of this strategy, the scientists have designed, synthesized and are evaluating a novel series of highly potent HIV protease inhibitors that appear promising against drug resistant variants of HIV protease.


Contact: Kelly Bishop
University of Massachusetts Medical School

Related biology news :

1. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
2. Automatic extraction of gene/protein biological functions from biomedical text
3. Vital step in cellular migration described by UCSD medical researchers
4. Breakthrough method in nanoparticle synthesis paves the way for new pharmaceutical and biomedical applications
5. Medical molecules designed to respond to visible light that can penetrate tissue
6. Medical whistleblowers speak out
7. UCSD medical/bioengineering reseachers show titanium debris satobtage artificial joints
8. Innovative coating could give medical implants a longer life
9. Natural tumor suppressor in body discovered by UCSD medical researchers
10. Protein synthesis can be controlled by light, opening way for new scientific, medical applications
11. Modified collagen could yield important medical applications
Post Your Comments:
(Date:11/16/2015)... , Nov 16, 2015  Synaptics Inc. (NASDAQ: ... interface solutions, today announced expansion of its TDDI ... touch controller and display driver integration (TDDI) ... smartphones. These new TDDI products add to the ... resolution), TD4302 (WQHD resolution), and TD4322 (FHD resolution) ...
(Date:11/12/2015)... LONDON , Nov. 11, 2015   ... and reliable analytical tools has been paving the ... and qualitative determination of discrete analytes in clinical, ... sensors are being predominantly used in medical applications, ... and environmental sectors due to continuous emphasis on ...
(Date:11/10/2015)... About signature verification Signature ... identify and verify the identity of an individual ... secure and accurate method of authentication and is ... because each individual,s signature is highly unique. Signature ... signature of an individual is compared and matched ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... , Nov. 24, 2015 Halozyme Therapeutics, Inc. (NASDAQ: ... Conference in New York on Wednesday, December ... Helen Torley , president and CEO, will provide a corporate overview. ... New York at 1:00 p.m. ET/10:00 a.m. PT . ... investor relations, will provide a corporate overview. --> th ...
(Date:11/24/2015)... Global, Inc., a worldwide provider of clinical research services headquartered in ... company has set a new quarterly earnings record in Q3 of ... for Q3 of 2014 to Q3 of 2015.   ... with the establishment of an Asia-Pacific office ... Kingdom and Mexico , with the ...
(Date:11/24/2015)... , November 24, 2015 ... recent market research report released by Transparency Market Research, ... expand at a CAGR of 17.5% during the period ... Testing Market - Global Industry Analysis, Size, Volume, Share, ... global non-invasive prenatal testing market to reach a valuation ...
(Date:11/24/2015)... ... November 24, 2015 , ... InSphero AG, the leading supplier of easy-to-use ... promoted Melanie Aregger to serve as Chief Operating Officer. , Having joined ... management team and was promoted to Head of InSphero Diagnostics in 2014. ...
Breaking Biology Technology: