Navigation Links
UMass Medical School researchers discover a new role for RNAi
Date:6/26/2012

orresponding piRNA is absent.

"It appears that piRNAs are responsible for the initial scanning and identification of foreign nucleic acids," said Darryl Conte Jr., PhD, research assistant professor of molecular medicine and one of the co-authors on the Cell papers. "Because the foreign DNA in successive generations is being silenced, even in worms that don't have the piRNA, the information necessary for silencing is being passed on epigenetically and independently of the initial scanning done by the piRNA complex in the previous generations."

Originating from clustered regions of the genome, piRNA are diverse and abundant small non-coding RNA molecules in animals, numbering in the millions in mammals. For the most part, piRNAs in worms and many piRNAs in mammalslack obvious complementary targets and their function is not clearly understood. It's possible that piRNAs act as a genetic security system, using imperfect base pairing to help identify foreign nucleic acids, said Dr. Conte.

So what prevents piRNAs from recognizing and permanently silencing a gene that the worm identifies as its own? Remarkably, the authors found that such "self" transcripts are somehow protected from entering the WAGO system and that some active genes can actually turn on silent genes. Because the self transcripts are associated with a third Argonaute known as CSR-1, the authors propose that CSR-1 provides an anti-silencing or protective function, which licenses the expression of genes that the worm recognizes as its own.

"This is one of the truly unique findings of these studies," said Conte. "Before, we knew that the RNAi process could be used to regulate genes or to turn them off completely. In this case, what we see is an RNAi mechanism that appears to prevent a gene from being silenced by the piRNA pathway. It works almost as a form of protection that allows the gene to be expressed."

"Taken together, these studies posit a surprisingly com
'/>"/>

Contact: Jim Fessenden
james.fessenden@umassmed.edu
508-856-2000
University of Massachusetts Medical School
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. UMass Medical School scientist named 2012 Pew Latin-American Fellow in the Biomedical Sciences
2. UMass Amherst wildlife researcher photographs rare Sumatran rabbit
3. Chemical engineers at UMass Amherst find high-yield method of making xylene from biomass
4. NIST/UMass study finds evidence nanoparticles may increase plant DNA damage
5. Alnylam and UMass Medical School announce Tuschl I patent upheld in European opposition proceedings
6. Resveratrol may be a natural exercise performance enhancer: U of A medical research
7. Top young Latin-American scientists named Pew Biomedical Fellows
8. 22 of Americas most promising scientists selected as Pew Biomedical Scholars
9. NIST effort could improve high-tech medical scanners
10. ESMO 2012 Congress: A path for medical oncology innovations
11. Nanotechnology breakthrough could dramatically improve medical tests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... DUBLIN , Dec. 18, 2014 Research and ... addition of the "Micro Market Monitor: North America ... http://photos.prnewswire.com/prnh/20130307/600769 ... grow at a CAGR of 3.6% from 2014 to ... in this market, Canada is ...
(Date:12/17/2014)... 15, 2014 Research and Markets ... the "Samsung Galaxy S5 - Home Button ... their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... sensing technology than the iPhone 5S, Samsung introduces ... its product. The Galaxy S5 home ...
(Date:12/17/2014)... , Dec. 16, 2014 Valencell, a leader ... PerformTek biometric technology to industry leaders such as Intel, ... clinically validated, biometric wearable products. These products will be ... Las Vegas . ... accurate, flexible and robust – with the clinical data ...
Breaking Biology News(10 mins):Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2
... -- Studying animals in behavioral experiments has been a ... relevant for human behavior has been unclear. Weill Cornell ... DNA of a gene that imparts similar anxiety-related behavior ... can be accurately used to study these human behaviors. ...
... A major 7.0-magnitude earthquake struck the Haitian capital ... damage. The quake was followed by several aftershocks with ... make current maps suddenly out of date, causing additional ... satellite images can help rescue efforts by providing updated ...
... effects of climate change on the spread of infectious ... focus of a nearly $1.9 million grant from the ... a Penn State-led group of researchers. The grant is ... Recovery and Reinvestment Act. Climate change has the potential ...
Cached Biology News:Animal behavioral studies can mimic human behavior 2First satellite map of Haiti earthquake 2First satellite map of Haiti earthquake 3Stimulus grant to support research on climate and infectious disease 2
(Date:12/19/2014)... (PRWEB) December 18, 2014 iLab Solutions, ... the appointment of Siri Bryant as the new Director ... Director of Core Implementations. These two new leadership positions ... customer service by ensuring that iLab continues to meet ... the last four years, iLab has been deployed at ...
(Date:12/19/2014)... 2014 Egenix, Inc. is pleased to announce that ... the Board, to succeed Donald Fresne ; Mr. Fresne ... as a member of the Board.  In recognition of the ... company over almost twenty years, the Board designated Mr. Fresne ... has established a Search Committee to find a suitable replacement ...
(Date:12/17/2014)... 2014 “Never say, ‘I cannot ... Marburg’s Department of Physics, advises young women pursuing ... released SPIE Women in Optics 18-month planner ... to ask questions.” , In the annual planner, ... occupations ranging from university professor and laboratory researcher ...
(Date:12/17/2014)... Indianapolis, IN (PRWEB) December 17, 2014 ... for Laboratory Excellence following its most recent COLA ... Accreditation by COLA, a national healthcare accreditation organization. ... rigid standards of quality in day-to-day operations, demonstrate ... and pass a rigorous on-site laboratory survey. ...
Breaking Biology Technology:iLab Solutions Announces Two New Leadership Positions to Meet the Needs of Its Growing Customer Base 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 3Xeno Diagnostics Receives 3rd Award for Laboratory Excellence 2
... Sept. 9 EnVivo Pharmaceuticals today announced the appointment of ... officer. DiPalma is responsible for overall financial operations for ... "EnVivo has grown to the point where we ... broad pipeline and increasing business opportunities," said Kees Been, CEO ...
... , DURHAM, N.C., Sept. 9 Oxygen Biotherapeutics, ... is being mailed today, asks shareholders to approve a 1-for-15 reverse ... , "At last years, general annual meeting we ... bulletin board and we promised to seek a listing change as ...
... , , , SAN DIEGO, Sept. 9 ... on the treatment of obesity, today announced that the Company will be speaking ... , , , Morgan Stanley Global Healthcare ... Time: 9:45am Eastern Time, Location: Grand Hyatt Hotel, ...
Cached Biology Technology:EnVivo Pharmaceuticals Names Stephen DiPalma Chief Financial Officer 2Oxygen Biotherapeutics, Inc. Seeks Shareholder Approval for Reverse Stock Split 2
Rabbit Serum New Zealand or California Origin...
Collected from 8-12 week old New Zealand or Californian rabbits. Aseptically collected and processed to minimize hemolytic activity. Pricing: $60/unit for 1 - 10 units...
... Customer Peptide Synthesis , Containing one Phospho-Amino Acid ... returned to customer conjugation of peptide to KLH protein , ... 102 days/each , Pre-immune bleed x1 /each ... Test bleed (app. 5 ml) x1 /each ...
... is collected off the clot fasted non-Swiss Albino mice ... Available Anticoagulants: N-02: Citrate N-04: ... Potassium Oxalate N-10: EDTA (Na) ... CPD N-09: K3EDTA N-11: ...
Biology Products: