dentifying microRNAs, the very short (20-24 nucleotide-long) single-stranded RNA molecules that are understood to play a critical role in gene regulation. microRNAs were originally discovered by Ambros and his lab in 1993 in the pathways controlling embryonic development in the nematode worm C. elegans, and at first seemed related only to a specific event in the worms development, and nothing more. Some years later, however, colleagues at Massachusetts General Hospital, the Whitehead Institute and the Max Planck Institute found more microRNAs, and since then, Ambros and others have identified a wide variety of genes for diverse microRNAs in animals and plants, raising new questions about gene regulation and expression. The discovery garnered the Newcomb Cleveland Prize in 2003 for the most significant paper published in the journal Science, an award given by the American Association for the Advancement of Science.
Others being presented with the Gairdner International Award are
- Dr. Nahum Sonenberg, PhD, Professor, Department of Biochemistry and McGill Cancer Centre, McGill University in Montreal, for his discovery of important mechanisms that control the synthesis of proteins in human cells;
- Dr. Samuel Weiss, PhD, Professor of Cell Biology and Anatomy and Pharmacology and Therapeutics, University of Calgary, for the discovery that the adult brain produces stem cells that can be used to re-grow damaged neural tissue;
- Professor Harald zur Hausen, DSc, MD, Professor Emeritus and recent Chair and Scientific Director of the German Cancer Research Centre in Heidelberg, who discovered that the human papilloma virus (HPV) causes cervical cancer, a discovery that led directly to the HPV vaccine; and
- Dr. Allan Bernstein, OC, PhD, Executive Director of the Global HIV Vaccine Enterprise in New York.
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