Navigation Links
UMN research uncovers structure, protein elements critical to human function and disease
Date:6/25/2014

MINNEAPOLIS/ST. PAUL (June 23, 2014) New structures discovered within cilia show a relationship between certain proteins and juvenile myoclonic epilepsy. The discovery, made at the University of Minnesota, was named paper of the week in the Journal of Biological Chemistry, and sheds new light on the microstructure of cilia.

Cilia are microscopic, hair-like structures occurring in large numbers on the surface of some of the body's cells and are involved in movement and perception. Cilia are composed of double microtubules, which are in turn composed of protofilaments.

Richard Linck, Ph.D., professor in the College of Biological Sciences and the Medical School at the University of Minnesota, worked closely with a team to identify specialized ribbons of four protofilaments within the microtubules of cilia. The function of these ribbons had been elusive to researchers, but unlocking the function of these elements improves understanding of how they fit into the bigger picture.

Utilizing cryo-electron tomography and sea urchin sperm tails, researchers identified a single ribbon of four protofilaments in each microtubule, with each microtubule containing a single filament of the protein tektin. Despite the extremely high resolution and protofilament ribbon identifications, there is still a small zone of confusion where the filament meets the ribbon. Thus, it is remains unclear how the filament fits into the structure of the ribbon.

"This discovery may not seem like a giant leap, but it does help us answer some pretty major questions," said Linck. "This structural mapping, similar to taking apart an engine to understand the subcomponents, allows us to see inside cilia. We're getting the highest resolution on this structure to date and finding where the parts belong and how they contribute to the overall structure and function."

As part of the push for structural mapping, Linck and his research team applied bioche
'/>"/>

Contact: Caroline Marin
crmarin@umn.edu
612-624-5680
University of Minnesota Academic Health Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Research reveals first evidence of hunting by prehistoric Ohioans
3. Diabetes Research Institute develops oxygen-generating biomaterial
4. APS issues new policy requiring identification of sex or gender in reporting scientific research
5. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
6. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
7. U of Alberta researcher steps closer to understand autoimmune diseases
8. Research on flavanols and procyanidins provides new insights into how these phytonutrients may positively impact human health
9. A project to research biological and chemical aspects of microalgae to fuel approach
10. Scripps Research discoveries lead to newly approved drug for infant respiratory distress syndrome
11. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/6/2014)... a predator. Except when that predator runs so fast that ... its size, is the fastest creature on Earth. Some of ... (at about five miles per hour). The fastest human can ... from the tiger beetle, a person would have to hit ... a problem. At peak speeds, everything becomes a blur. They ...
(Date:11/4/2014)... CITY, Nov. 5, 2014 – University of Utah engineers ... to help jet fuel produce electricity without needing to ... used to power portable electronics, off-grid power and sensors. ... today in the American Chemical Society journal ACS ... through a chemical reaction between a fuel and an ...
(Date:11/4/2014)... England , November 4, 2014 ... and vertical market growth   Fuel3D , ... has closed a funding round totaling $6.4 million (£4 million). ... million) funding secured earlier this year and paves the way ... in 2015. The funding round was led by ...
Breaking Biology News(10 mins):The tiger beetle: Too fast to see 2Jet-fueled electricity at room temperature 2Fuel3D Secures $6.4 Million in Expansion Funding 2Fuel3D Secures $6.4 Million in Expansion Funding 3
... STATION N.J., PRINCETON, N.J. and JAMAICA PLAIN, Mass., ... (through an affiliate), Medarex, Inc. (NASDAQ: MEDX) and ... Massachusetts Medical School (UMMS) today announced that they ... CDA-1 and CDB-1 (also known as MDX-066/MDX-1388 and ...
... Cambridge, UK Wolf-Hirschhorn Syndrome (WHS) is a human ... with WHS have a characteristic set of facial features, ... forehead, and highly arched eyebrows. Other symptoms associated ... and skeletal abnormalities, and the severity of these symptoms ...
... AWRE ) today announced that it has amended and ... of comments and a request from the Securities and Exchange ... range of the tender offer to between $2.20 and $2.60 ... share. Aware has also extended the expiration date for the ...
Cached Biology News:Mass Biologic Labs/UMass Med School and Medarex license C. difficile monoclonal antibody to Merck 2Mass Biologic Labs/UMass Med School and Medarex license C. difficile monoclonal antibody to Merck 3Mouse model provides a new tool for investigators of human developmental disorder 2Aware, Inc. Amends and Extends Dutch Auction Tender Offer 2Aware, Inc. Amends and Extends Dutch Auction Tender Offer 3Aware, Inc. Amends and Extends Dutch Auction Tender Offer 4
(Date:11/27/2014)... , Nov. 27, 2014 Research ... "Global Palmitic Acid Industry Report 2014" report ... The Global Palmitic Acid Industry Report ... current state of the global palmitic acid industry. ... industry including definitions, classifications, applications and industry chain structure. ...
(Date:11/27/2014)... BELLINGHAM, Washington, and PITTSFIELD, Massachusetts, USA (PRWEB) November 26, ... pinpoint cancer cells with more accuracy, additive systems to ... improve highway safety by analyzing road conditions are among ... Awards for Photonics Innovation . The awards are sponsored ... photonics , and Photonics Media . , Winners ...
(Date:11/26/2014)... 2014 The North America Thermal ... market for detailed analysis of the growth trends ... reach $616.3 million by 2018, growing at a ... Browse through the TOC of the North America ... idea of the in-depth analysis and industry segmentation ...
(Date:11/26/2014)... Nov. 26, 2014 The Alliance ... a survey of European physicians at the "1 ... and Biological Therapies" at the Spanish Ministry of ... by EuropaBio and the Spanish Bioindustry Association (ASEBIO), ... physicians from Spanish oncology and rheumatology societies, representatives ...
Breaking Biology Technology:Global Palmitic Acid Industry Report 2014 2Finalists Named for 2015 Prism Awards for Photonics Innovation 2Finalists Named for 2015 Prism Awards for Photonics Innovation 3Finalists Named for 2015 Prism Awards for Photonics Innovation 4Finalists Named for 2015 Prism Awards for Photonics Innovation 5The North America Thermal Protective Clothing Market is estimated to grow up to $616.3 million by 2018 - Report by MicroMarket Monitor 2The North America Thermal Protective Clothing Market is estimated to grow up to $616.3 million by 2018 - Report by MicroMarket Monitor 3ASBM Presents European Physicians Survey at Spanish Ministry of Health 2
... power supply is an all-purpose power supply , Douglas Drake Michelle Cayouette ... , , , ... Supply, Stratagene has developed the new ... power supply for any, electrophoretic application. The SmartPower 4000 power ...
... , , , ,,,, , A time-saving alternative to conventional library plating and screening ... , , ... , Department of Cell Biology, Cleveland Clinic Foundation, , ... , , ...
... powerful method to detect protein interactions in mammalian ... ,Stratagene , With Stratagenes mammalian two-hybrid assay kit, ... interactions via the activation,of reporter gene expression. This ... functional transcription factor caused by the association of,two ...
Cached Biology Technology:A Versatile Power Supply for All Electrophoresis Applications 2A Versatile Power Supply for All Electrophoresis Applications 3A Versatile Power Supply for All Electrophoresis Applications 4A Versatile Power Supply for All Electrophoresis Applications 5Low Abundance cDNA Cloned Using Stratagenes Human Universal , cDNA Library 2Low Abundance cDNA Cloned Using Stratagenes Human Universal , cDNA Library 3Low Abundance cDNA Cloned Using Stratagenes Human Universal , cDNA Library 4Low Abundance cDNA Cloned Using Stratagenes Human Universal , cDNA Library 5Low Abundance cDNA Cloned Using Stratagenes Human Universal , cDNA Library 6New Mammalian Two-Hybrid System Detects Protein-Protein Interactions 2New Mammalian Two-Hybrid System Detects Protein-Protein Interactions 3New Mammalian Two-Hybrid System Detects Protein-Protein Interactions 4New Mammalian Two-Hybrid System Detects Protein-Protein Interactions 5New Mammalian Two-Hybrid System Detects Protein-Protein Interactions 6New Mammalian Two-Hybrid System Detects Protein-Protein Interactions 7New Mammalian Two-Hybrid System Detects Protein-Protein Interactions 8New Mammalian Two-Hybrid System Detects Protein-Protein Interactions 9
... marker is specifically designed for two-dimensional ... The four proteins in this marker ... diagonal pattern across a 2D gel. ... 3.8. Mol wt: ...
High-throughput DNA preparation and end sequencing of BAC libraries. 3730xl DNA sequencers. LIMS tracking utilizing Geospiza's Finch system. Full-length BAC sequencing also available. Our expertise h...
...
Methylation analysis of gene promoters using bilsulfite treatment of DNA and comparative DNA sequence analysis. Probe design and PCR included....
Biology Products: