Navigation Links
UMN research uncovers structure, protein elements critical to human function and disease
Date:6/25/2014

MINNEAPOLIS/ST. PAUL (June 23, 2014) New structures discovered within cilia show a relationship between certain proteins and juvenile myoclonic epilepsy. The discovery, made at the University of Minnesota, was named paper of the week in the Journal of Biological Chemistry, and sheds new light on the microstructure of cilia.

Cilia are microscopic, hair-like structures occurring in large numbers on the surface of some of the body's cells and are involved in movement and perception. Cilia are composed of double microtubules, which are in turn composed of protofilaments.

Richard Linck, Ph.D., professor in the College of Biological Sciences and the Medical School at the University of Minnesota, worked closely with a team to identify specialized ribbons of four protofilaments within the microtubules of cilia. The function of these ribbons had been elusive to researchers, but unlocking the function of these elements improves understanding of how they fit into the bigger picture.

Utilizing cryo-electron tomography and sea urchin sperm tails, researchers identified a single ribbon of four protofilaments in each microtubule, with each microtubule containing a single filament of the protein tektin. Despite the extremely high resolution and protofilament ribbon identifications, there is still a small zone of confusion where the filament meets the ribbon. Thus, it is remains unclear how the filament fits into the structure of the ribbon.

"This discovery may not seem like a giant leap, but it does help us answer some pretty major questions," said Linck. "This structural mapping, similar to taking apart an engine to understand the subcomponents, allows us to see inside cilia. We're getting the highest resolution on this structure to date and finding where the parts belong and how they contribute to the overall structure and function."

As part of the push for structural mapping, Linck and his research team applied bioche
'/>"/>

Contact: Caroline Marin
crmarin@umn.edu
612-624-5680
University of Minnesota Academic Health Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Research reveals first evidence of hunting by prehistoric Ohioans
3. Diabetes Research Institute develops oxygen-generating biomaterial
4. APS issues new policy requiring identification of sex or gender in reporting scientific research
5. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
6. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
7. U of Alberta researcher steps closer to understand autoimmune diseases
8. Research on flavanols and procyanidins provides new insights into how these phytonutrients may positively impact human health
9. A project to research biological and chemical aspects of microalgae to fuel approach
10. Scripps Research discoveries lead to newly approved drug for infant respiratory distress syndrome
11. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2014)... Millar , a professor of entomology and ... at the University of California, Riverside, has been ... International Society of Chemical Ecology ( ISCE ). , ... is the society,s highest honor. It is awarded ... chemical ecology, the study of chemicals that mediate interactions ...
(Date:7/21/2014)... has issued a high health risk warning for Yellowknife ... region due to forest fires. Currently 160 wildfires ... plans for evacuation since these fires are endangering people ... area recently comes with mixed results. The rains ... to start others. , This year the Northern Territories ...
(Date:7/21/2014)... A University of California, San Diego School of Medicine-led ... not recognize the potentially serious health consequences of childhood ... in helping their child reach a healthy weight. , ... of the Academy of Nutrition and Dietetics . , ... and physical activity behaviors," said lead author Kyung Rhee, ...
Breaking Biology News(10 mins):UC Riverside entomologist receives international honor for chemical ecology contributions 2Parents rank their obese children as 'very healthy' 2
... that a group of genetic rogue elements, produced by DNA ... and bowel cancer. Their research, funded by Cancer Research UK, ... The researchers, led by Dr Cristina Tufarelli, in the School ... of these faulty genetic elements known as chimeric transcripts ...
... discussion and debate emanating from the COP15 United ... expected, the majority of climate change discussion surrounding ... - regulations to restrict carbon emissions, exploration of ... Paradise Regained: The Regreening of Earth (Springer, $27.50) ...
... from the Institute for Animal Health, Pirbright, UK Met ... Meteorological Department, are working together on an early-warning system ... disease, reveals a study published today in Weather ... information to anticipate when disease carrying midges are likely ...
Cached Biology News:'Junk DNA' could spotlight breast and bowel cancer 2Global warming and other environmental dangers may be solved by unlikely source -- space technology 2Scientists create early-warning system to defend rare Jersey cows from continental disease 2
(Date:7/22/2014)... The DNA Spectrum Ancestry Map ... of history, migration, and culture. , Throughout his ... history stories stemming from Europe. His father passionately referred ... and 8mm home movies painted an elaborate picture of ... Steve ordered a test from DNA Spectrum to expand ...
(Date:7/22/2014)... CAMBRIDGE, Massachusetts e SHENZHEN ... Solutions Co., LTD, (BGI Tech), una filiale di BGI, ... il lancio mondiale di un nuovo servizio di sequenziamento ... settore di Complete Genomics. Complete Genomics, ... fornire tecnologie di sequenziamento proprietarie con il 99.999% di ...
(Date:7/22/2014)... Ore. , July 22, 2014  Semler ... an emerging medical risk assessment company that develops ... patients and evaluating chronic diseases, today announced that ... before the open of U.S. financial markets on July ... Semler will host a conference call at 11 a.m. ...
(Date:7/22/2014)... New Jersey , 22. Juli 2014 /PRNewswire/ ... die Life-Sciences-Industrie, hat die Ernennung von Marcus Bergler ... bekanntgegeben. Herr Bergler hat die europäischen kommerziellen Aktivitäten ... unterstützt. Bevor er sich Qforma anschloss, war er ... Cegedim Customer Information, als Vertriebsteam-Leiter Deutschland bei IMS ...
Breaking Biology Technology:DNA Test from DNA Spectrum Shows Heritage Like a Map of the Past 2DNA Test from DNA Spectrum Shows Heritage Like a Map of the Past 3DNA Test from DNA Spectrum Shows Heritage Like a Map of the Past 4BGI Tech lancia un servizio di sequenziamento dell'intero esoma umano sulla piattaforma avanzata di Complete Genomics 2Semler to Report Second Quarter 2014 Financial Results and Host Conference Call on July 25, 2014 2Qforma gibt Schaffung des neuen Postens als General Manager in Europa bekannt 2
... - GeneNews Limited (TSX: GEN),a company focused ... the early detection of diseases and personalized ... collecting patient samples,for clinical validation studies of ... June 2006, GeneNews presented training set results ...
... /PRNewswire-FirstCall/ - Helix BioPharma Corp.,(TSX, FSE: "HBP") today ... by way of private placement, of a total ... gross proceeds totaling CDN$16,867,200.,Proceeds from the placement will ... Company,s research and development initiatives., The Company ...
... and Product Development Company to Establish Presence in ... UK/European Market from the Midlands, ... announced that Nebraska based GeneSeek has chosen the British,Midlands as ... be setting up their new base of operations in BioCity,Nottingham, ...
Cached Biology Technology:GeneNews initiates patient sample accrual for validation studies of colon cancer blood test 2GeneNews initiates patient sample accrual for validation studies of colon cancer blood test 3Helix BioPharma announces $16.9 million private placement of common shares 2GeneSeek Selects the British Midlands as Base for New UK/European Operations 2GeneSeek Selects the British Midlands as Base for New UK/European Operations 3
... Adhesive seal tabs • Reusable, ... can be quickly assembled and disassembled for ... specimens of any thickness with up to ... three chambers per slide. Minimize specimen handling, ...
Comp Dim: chamber diam. depth 20 2.8 mm chamber maximum volume 720 μL...
...
... assays, all EIA/RIA plates are manufactured from ... optical clarity and low background absorption. In ... Certified Surface Chemistry Programme, which guaarantees protein ... specifications. Linkage: This CLS number is a ...
Biology Products: