Navigation Links
UMN research uncovers structure, protein elements critical to human function and disease
Date:6/25/2014

MINNEAPOLIS/ST. PAUL (June 23, 2014) New structures discovered within cilia show a relationship between certain proteins and juvenile myoclonic epilepsy. The discovery, made at the University of Minnesota, was named paper of the week in the Journal of Biological Chemistry, and sheds new light on the microstructure of cilia.

Cilia are microscopic, hair-like structures occurring in large numbers on the surface of some of the body's cells and are involved in movement and perception. Cilia are composed of double microtubules, which are in turn composed of protofilaments.

Richard Linck, Ph.D., professor in the College of Biological Sciences and the Medical School at the University of Minnesota, worked closely with a team to identify specialized ribbons of four protofilaments within the microtubules of cilia. The function of these ribbons had been elusive to researchers, but unlocking the function of these elements improves understanding of how they fit into the bigger picture.

Utilizing cryo-electron tomography and sea urchin sperm tails, researchers identified a single ribbon of four protofilaments in each microtubule, with each microtubule containing a single filament of the protein tektin. Despite the extremely high resolution and protofilament ribbon identifications, there is still a small zone of confusion where the filament meets the ribbon. Thus, it is remains unclear how the filament fits into the structure of the ribbon.

"This discovery may not seem like a giant leap, but it does help us answer some pretty major questions," said Linck. "This structural mapping, similar to taking apart an engine to understand the subcomponents, allows us to see inside cilia. We're getting the highest resolution on this structure to date and finding where the parts belong and how they contribute to the overall structure and function."

As part of the push for structural mapping, Linck and his research team applied biochemical analysis to the ribbon. In this assessment, several proteins have been localized to the ribbon, including tektin and two others casually associated with human disease, including juvenile myoclonic epilepsy.

It is still unclear if the cilia are directly involved in the cause of the epilepsy and other diseases, or if the relevant proteins function in other, non-ciliary ways to cause disease. However, the mapping itself begins to unlock those clues.

Future research is needed to understand the relationship of these ribbon-associated proteins to human disease, as well as to better understand how the filament is structured in the larger ribbon.


'/>"/>

Contact: Caroline Marin
crmarin@umn.edu
612-624-5680
University of Minnesota Academic Health Center
Source:Eurekalert

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Research reveals first evidence of hunting by prehistoric Ohioans
3. Diabetes Research Institute develops oxygen-generating biomaterial
4. APS issues new policy requiring identification of sex or gender in reporting scientific research
5. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
6. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
7. U of Alberta researcher steps closer to understand autoimmune diseases
8. Research on flavanols and procyanidins provides new insights into how these phytonutrients may positively impact human health
9. A project to research biological and chemical aspects of microalgae to fuel approach
10. Scripps Research discoveries lead to newly approved drug for infant respiratory distress syndrome
11. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/20/2016)... -- VoiceIt is excited to announce its new marketing ... working together, VoiceIt and VoicePass will offer an ... slightly different approaches to voice biometrics, collaboration between ... Both companies ... "This marketing and technology partnership allows VoiceIt ...
(Date:4/28/2016)... BANGALORE, India , April 28, 2016 ... of Infosys (NYSE: INFY ), and Samsung SDS, ... partnership that will provide end customers with a more ... payment services.      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ) ... financial services, but it also plays a fundamental part in ...
(Date:4/15/2016)...  A new partnership announced today will help ... in a fraction of the time it takes ... life insurance policies to consumers without requiring inconvenient ... Diagnostics, rapid testing (A1C, Cotinine and HIV) and ... weight, pulse, BMI, and activity data) available at ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June, 23, 2016  The Biodesign Challenge ... envision new ways to harness living systems and biotechnology, ... Art (MoMA) in New York City ... 130 participating students, showcased projects at MoMA,s Celeste Bartos ... Paola Antonelli , MoMA,s senior curator of architecture and ...
(Date:6/23/2016)... ... ... STACS DNA Inc., the sample tracking software company, today announced that Dr. Hays ... DNA as a Field Application Specialist. , “I am thrilled that Dr. Young ... DNA. “In further expanding our capacity as a scientific integrator, Hays brings a wealth ...
(Date:6/23/2016)... June 23, 2016  Blueprint Bio, a company dedicated ... the medical community, has closed its Series A funding ... . "We have received a commitment from ... we need to meet our current goals," stated ... the runway to complete validation on the current projects ...
(Date:6/23/2016)... ... 23, 2016 , ... ClinCapture, the only free validated electronic ... showcase its product’s latest features from June 26 to June 30, 2016 for ... Disrupting Clinical Trials in The Cloud during the conference. DIA (Drug Information ...
Breaking Biology Technology: