Navigation Links
UMMS researchers uncover novel genetic pathway responsible for triggering vascular growth
Date:4/4/2010

WORCESTER, Mass. Most solid cancers can't grow beyond a limited size without an adequate blood supply and supporting vascular network. Because of this, cancer researchers have sought to understand how a tumor's vascular network developsand, more importantly, how to prevent it from developing: If the vascular network never develops, the theory goes, the tumor cannot grow.

Researchers at the University of Massachusetts Medical School have discovered a critical step for blood vessel growth in zebrafish embryos, providing new insight into how vascular systems develop and offering a potential therapeutic target for preventing tumor growth. UMMS Associate Professor of Molecular Medicine and the Program in Gene Function and Expression Nathan Lawson, PhD, and colleagues have identified a novel microRNA-mediated genetic pathway responsible for new blood vessel growth, or angiogenesis, in zebrafish embryos. Published online by Nature, Dr. Lawson's work provides new insights into how vascular systems use the forces of existing blood flow to initiate the growth of new vessels.

Focusing on the development of the fifth and sixth aortic arches in the zebrafish, Dr. Lawson describes how the forces exerted by blood flow on endothelial cells are a critical component for expressing a microRNA that triggers new vessel development. In the early stages of development, when blood flow is present in the aortic vessels, but the vascular linkages between the two arches have yet to be established, the stimulus provided by active blood flow leads to expression of an endothelial-cell specific microRNA (mir-126). In turn, this microRNA turns on vascular endothelial growth factor (VEGF), a chemical signal produced by surrounding cells that normally stimulates angiogenesis. Thus, blood flow allows the endothelial cells to respond to VEGF by growing into new blood vessels. However, when blood flow in the aortic arches was restricted, mir-126 failed to be expressed.
'/>"/>

Contact: Jim Fessenden
james.fessenden@umassmed.edu
508-856-2000
University of Massachusetts Medical School
Source:Eurekalert

Page: 1 2

Related biology news :

1. Longer-lasting flowers: Fresh ideas from ARS researchers
2. Researchers discover weak link in Alzheimers drug candidates
3. Researchers sequence DNA of peach tree at Clemson University
4. Researchers develop new method to detect melamine in milk
5. Researchers sequence DNA if peach tree at Clemson University
6. New brain nerve cells key to stress resilience, UT Southwestern researchers find
7. Researchers harness the power of plants to fight hemophilia
8. U of I researchers say foliar fungicides may not be the answer for hail-damaged corn
9. Researchers look at reducing yield loss for crops under stress
10. UT Southwestern researchers find clues to TB drug resistance
11. U of I researchers identify new soybean aphid biotype
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... have added "playwright" to their resumes in an effort ... onslaught of ethical issues as genomic science transitions to ... first sequenced. , Until now the plays of ... performed for, and by, their peers and others in ... classrooms. With Oxford University Press, publication of the ...
(Date:4/23/2014)... A new study from the Indiana University School of ... consumption and heart disease by finding a strong association ... deadly coronary heart disease. , The study found that ... disease by 57 percent, while no association was found ... non-meat sources, and coronary heart disease. , The study ...
(Date:4/23/2014)... Scarborough research shows that male black widow spiders prefer ... rare example of mate preference by male spiders. ... MacLeod and Maydianne Andrade, a professor in UTSC,s Department ... and the wild that males overwhelmingly chose to mate ... widows can tell whether a potential mate is well-fed ...
Breaking Biology News(10 mins):Bioethicists use theatrical narratives to bridge the gap between society and science 2Bioethicists use theatrical narratives to bridge the gap between society and science 3Study: Iron consumption can increase risk for heart disease 2Picky male black widow spiders prefer well-fed virgins 2
... team of scientists from the Johns Hopkins University ... method to accurately predict dengue fever outbreaks several ... method, known as PRedicting Infectious Disease Scalable Model ... socio-political data in Peru and in the Philippines. ...
... Neck, NY) The Brain & Behavior Research Foundation ... Schizophrenia and Depression) has announced approximately $4 million in ... close to $300 million in research to identify the ... illness. From about 500 applicants, forty research scientists ...
... Reportlinker.com announces that a new market research report ... Hand Geometry Industry http://www.reportlinker.com/p01139076/Global-Hand-Geometry-Industry.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Security_Systems ... in US$ Thousands. The report provides separate comprehensive analytics ... Japan , Europe , ...
Cached Biology News:APL novel method accurately predicts disease outbreaks 2Brain & Behavior Research Foundation awards nearly $4 million in new NARSAD grants 2Brain & Behavior Research Foundation awards nearly $4 million in new NARSAD grants 3Brain & Behavior Research Foundation awards nearly $4 million in new NARSAD grants 4Brain & Behavior Research Foundation awards nearly $4 million in new NARSAD grants 5Brain & Behavior Research Foundation awards nearly $4 million in new NARSAD grants 6Brain & Behavior Research Foundation awards nearly $4 million in new NARSAD grants 7Brain & Behavior Research Foundation awards nearly $4 million in new NARSAD grants 8Brain & Behavior Research Foundation awards nearly $4 million in new NARSAD grants 9Brain & Behavior Research Foundation awards nearly $4 million in new NARSAD grants 10Brain & Behavior Research Foundation awards nearly $4 million in new NARSAD grants 11Brain & Behavior Research Foundation awards nearly $4 million in new NARSAD grants 12Global Hand Geometry Industry 2Global Hand Geometry Industry 3Global Hand Geometry Industry 4Global Hand Geometry Industry 5Global Hand Geometry Industry 6Global Hand Geometry Industry 7Global Hand Geometry Industry 8Global Hand Geometry Industry 9
(Date:1/15/2014)... 15, 2014  Bill Jacobs Automotive, a group of car dealerships ... with the Heartland Blood Center and offering free oil change ... takes place Saturday, Jan. 18 at the Bill Jacobs Cadillac ... (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  The Bill ...
(Date:1/15/2014)... FALLS, N.Y., Jan. 15, 2014   Niagara Thermal Products ... by Buffalo BioBlower Technologies LLC ("B3") as the critical ... 2 award from the Army Corps of Engineers.  B3 ... kills all biological contaminants and destroys VOCs and other ...
(Date:1/15/2014)... Village, Calif. (PRWEB) January 15, 2014 ... treatment and management through the genomic analysis of tumor ... offer Therapy Finder™, a web-based cancer decision support application ... reporting option with Cynvenio’s ClearID™ genomic test, Therapy Finder ...
(Date:1/15/2014)... 2014 ­ RedBrick Health , a fast-growing leader ... announces that EmblemHealth , the New ... now providing the RedBrick Compass health assessment, combined with ... of its members. EmblemHealth is among the first health ...
Breaking Biology Technology:Join the Bill Jacobs Auto blood drive and receive a free oil change 2Niagara Thermal Products LLC Selected as Critical Supplier for Buffalo BioBlower Air Purification Systems 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 3
... Technology experts from over 20 countries are in ... environment, topics of global importance and immediacy. The ... forum to discuss initiatives in micromachining and nano ... economic and social outcomes. , The Summit promotes ...
... 6 Dendreon Corporation (Nasdaq: DNDN ) today reported ... for the first quarter of 2009 was $30,000 compared to $31,000 ... expenses for the three months ended March 31, 2009 were $17.0 ... The net loss for the quarter ended March 31, 2009 ...
... just six atoms thick in which electrons appear to ... their direction of travel has been discovered by a ... Working with computational models, the team has found that ... sandwiched between insulating sheets of titanium dioxide exhibit one ...
Cached Biology Technology:World Micromachine Summit highlights technologies impacting energy and the environment 2Dendreon Reports First Quarter 2009 Financial Results 2Dendreon Reports First Quarter 2009 Financial Results 3Dendreon Reports First Quarter 2009 Financial Results 4Dendreon Reports First Quarter 2009 Financial Results 5Nano-sandwich triggers novel electron behavior 2Nano-sandwich triggers novel electron behavior 3
2,4-Dinitrophenyl hapten is conjugated to BSA (Bovine Serum Albumin) protein through lysine....
4-Hydroxy-3-iodo-5-nitrophenylacetyl hapten is conjugated to BSA protein through lysine by amide bonds....
Amino Acid Analysis is performed using ion-exchange separation of the amino acids from acid hydrolysates, followed by ninhydrin detection. Typical quantities required are 0.1 to 0.5 mg, depending on...
2,4,6-Trinitrophenyl hapten is conjugated to Bovine Serum Albumin protein through lysine by amide bonds....
Biology Products: