Navigation Links
UMMS researchers identify protein associated with sporadic ALS
Date:10/18/2010

ALS, he hoped that one day research would provide insight into the more common sporadic form of the disease. "It's been hypothesized that there are common pathogenic pathways between familial and sporadic ALS," said Brown. "Our new findings strongly suggest that is the case."

To determine whether the SOD1 protein found in sporadic ALS cases had become toxic via non-inherited modifications, Bosco and colleagues showed that an antibody known to bind specifically to mutant SOD1 also binds to SOD1 modified by oxidation indicating that the oxidized SOD1 protein shared characteristics with the mutant SOD1 protein. Additional experiments showed further that in four out of nine samples from individuals with sporadic ALS, the same antibody recognized the SOD1 protein in spinal motor neurons, evidence that the protein had been modified in a similar way as the mutant SOD1 in familial ALS and in samples oxidized in the lab. Moreover, the SOD1 protein extracted from three of these cases proved toxic to the function of motor neurons in an experimental model.

"This research shows that under certain conditions and absent a mutation in the gene, a normal SOD1 protein can have the same toxic characteristics that are found in familial ALS where SOD1 gene is mutated," said Brown. "What's more, we found the presence of these aberrant proteins in select cases of sporadic ALS."

"Until now, factors linking both forms of ALS have been lacking," said Bosco. "These results demonstrate that this protein plays a role in both forms of the disease."

Bosco cautions that while a modified form of the SOD1 protein may play a part in sporadic cases of ALS, it's still unclear what is causing the modification, how many cases may be as a result of the modification or whether it is the primary cause of the disease. "Despite the presence of the normal gene, we show that modifications to the protein made by the gene makes it behave like the toxic, mutated forms of protein," said Bosco.
'/>"/>

Contact: Jim Fessenden
james.fessenden@umassmed.edu
508-856-2000
University of Massachusetts Medical School
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. NC State researchers get to root of parasite genome
2. Researchers find animal with ability to survive climate change
3. Researchers find an essential gene for forming ears of corn
4. Researchers note differences between people and animals on calorie restriction
5. Researchers study acoustic communication in deep-sea fish
6. Researchers discover that growing up too fast may mean dying young in honey bees
7. Researchers study how pistachios may improve heart health
8. UI researchers find potentially toxic substance present in Chicago air
9. Researchers develop new self-training gene prediction program for fungi
10. Case Western Reserve University researchers track Chernobyl fallout
11. Childrens National researchers develop novel anti-tumor vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2015)... , March 31, 2015   Guidepoint , ... launch of the Post-Surgical Pain Management TRACKER, part of ... tracking usage trends in the medical device and therapeutics ... to data including treatment volumes, market share, and adoption ... pain associated with joint surgery. The Post-Surgical ...
(Date:3/24/2015)... Research and Markets ( http://www.researchandmarkets.com/research/kvdtcw/face_and_voice ) has announced ... Strategic Business Report" report to their offering. This ... US$ Thousands by the following Segments: Face Biometrics, and Voice Biometrics. ... Canada , Japan , Europe ... & Africa , and ...
(Date:3/23/2015)... , March 23, 2015   HOYOS Labs ... management company, today announced that the Company will demonstrate ... both enterprise and consumers at Connect:ID on March 23 ... HOYOS Labs will highlight the IEEE Biometric Open ... ; and enterprise access control system. BOPS was ...
Breaking Biology News(10 mins):Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3
... found at Dinosaur Cove in Victoria, Australia, were likely ... the oldest known bird tracks in Australia. The ... the footprints led by Anthony Martin, a paleontologist at ... which include tracks, burrows and nests. The study was ...
... sandpipers ( Calidris pusilla ) feeding during low tide ... Beauchamp, an ornithologist and research officer at the University ... the periphery remained alert and used short pecks to ... the group relaxed their vigilance and fed on a ...
... This news release is available in French ... activity during a cognitive task even in some people who are ... University of Montreal and Boston,s Brigham and Women,s Hospital. The findings ... how quickly light impacts on cognition. "We were stunned to discover ...
Cached Biology News:Tell-tale toes point to oldest-known fossil bird tracks from Australia 2Tell-tale toes point to oldest-known fossil bird tracks from Australia 3Bird buffet requires surveillance 2Study with totally blind people shows how light helps activate the brain 2
(Date:5/1/2015)... BETHESDA, Md. , May 1, 2015  Northwest ... biotechnology company developing DCVax® personalized immune therapies for solid ... on the $28.5 million second tranche of a $40 ... ("Woodford"). Woodford first invested $25 million in ... 2015, Woodford entered into an agreement with the Company ...
(Date:5/1/2015)... /CNW/ - Softchoice, a leading North American IT solutions and managed ... of two Cisco® Partner Summit Country awards. ... Security Partner of the Year for Canada ... in Montreal . "We ... awards at this year,s conference," said David MacDonald , ...
(Date:5/1/2015)... 1, 2015 According to ... Product (Equipment, Consumables), by Type (Monoclonal, Polyclonal), by ... Research Institutes) - Analysis & Global Forecast to ... global Antibody Production Market for the forecast period ... to reach $2.572 Billion by 2019 from $1.425 ...
(Date:4/30/2015)... DIEGO , April 30, 2015   Tamir ... announced today an update on its Ebola antiviral therapy ... Tamir,s leading candidates, TMR004, is currently being evaluated and ... of the battle against Ebola. During the first quarter ... And Leadership Meeting To Accelerate The Evaluation of Potential ...
Breaking Biology Technology:NW Bio Closes On $28.5 Million Second Tranche Of Woodford $40 Million Financing 2NW Bio Closes On $28.5 Million Second Tranche Of Woodford $40 Million Financing 3Softchoice recognized with two Country Awards at Cisco Partner Summit 2015 2Antibody Production Market worth $2.572 Billion by 2019 2Antibody Production Market worth $2.572 Billion by 2019 3Antibody Production Market worth $2.572 Billion by 2019 4Tamir Biotechnology Provides Update on TMR004 Development Against Mutating Ebola 2Tamir Biotechnology Provides Update on TMR004 Development Against Mutating Ebola 3Tamir Biotechnology Provides Update on TMR004 Development Against Mutating Ebola 4
... Better Option for Humans, EGG HARBOR TOWNSHIP, ... first time, The British Institute of Homeopathy, U.S.A. ... U.S. medical and,homeopathic practitioners for a low-introductory cost ... therapy is more advantageous because,it does not carry ...
... Inc. (Nasdaq and SWX: BMRN) announced today the ... Research. Former Vice President of,Research and Development for ... biotechnology patents and the recipient of a,collection of ... Year Awards from Intellectual Property Owners, Inc., ...
... (Nasdaq: KNDL ), a,leading, global full-service clinical ... Officer Candace Kendle, PharmD,will participate in the Wachovia ... the Langham Hotel in Boston, Jan. 29-31, 2008. ... 1:30 p.m. Eastern Time., (Logo: http://www.newscom.com/cgi-bin/prnh/20030429/KNDLLOGO ...
Cached Biology Technology:BioMarin Appoints Dr. Gordon Vehar, Vice President of Research 2BioMarin Appoints Dr. Gordon Vehar, Vice President of Research 3Kendle to Present at the Wachovia 2008 Healthcare Conference 2
... PCR System is the only PCR system ... and every time. It provides accuracy, consistency, ... source or the property of the DNA ... Enzyme Mix, a unique blend of thermostable ...
ID clarifier: With ethidium bromide (50 μg/ml)...
Extremely high efficiency packaging extracts useful for transfecting our EpiFOS™ or CopyControl™ Fosmids, or any DNA vector with cos sites. A tremendous value when conpared to the competition...
... Buffer is a convenient, premixed, ... samples and Perfect RNA Markers. ... no dilution and is suitable ... Simply mix equal volumes of ...
Biology Products: