Navigation Links
UMMS researchers answer century old question about 3D structure of mitotic chromosomes
Date:11/7/2013

. In the first phase, chromatin loops of 80,000 to 120,000 DNA base pairs form, radiating out from a scaffold and compacting the chromosome linearly. This was followed by axial compression of the chromosome, much like a spring being compressed, resulting in a neat, tightly folded package.

"Each cell type, whether blood, skin or liver cell, has a unique structure and organization that is closely tied to gene expression and function," said Dekker. "When the cell begins to divide that structure is disassembled. The specific patterns or organization tied to cell type are stripped away and the universal mitotic chromosome is formed. The process results in each cell being condensed and repackaged in a way that is common across cells types and points to a fundamental process of cell biology."

"When you look at the condensed chromosome it appears to be highly organized," said Dekker. "But the truth is that the process is very variable and adaptable because these chromatin loops form randomly along the chromosomes, which makes the process incredibly robust and adaptable."

Natalia Naumova, PhD, a postdoctoral fellow at UMMS and one of the lead authors of the study said, "We didn't expect that the chromosome would be organized this way. This stochastic process, which is locally random, results more globally in a high degree of stability and robustness, which is needed for cells to divide successfully."

The next step for Dekker, Mirny and their teams is to determine what, precisely, is guiding the disassembling and reassembling of the chromosome. "Because most transcription largely ceases in mitosis, and many proteins dissociate from the chromosome, something has to be responsible for reassembling chromosomes after cell division according to their cell type. Understanding the organization of the mitotic chromosome will help to understand how things go wrong in disease caused by chromosome disorder such as cancer or Down syndrome."


'/>"/>

Contact: Jim Fessenden
james.fessenden@umassmed.edu
508-856-2000
University of Massachusetts Medical School
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. NIH funds researchers using light to control and monitor neural activity
2. Researchers regrow hair, cartilage, bone, soft tissues
3. Stanford researchers surprised to find how neural circuits identify information needed for decisions
4. Lawrence Livermore researchers unveil carbon nanotube jungles to better detect molecules
5. 23 researchers join network of EMBO Young Investigators
6. Breakthrough by Temple researchers could lead to new treatment for heart attack
7. Temple researchers uncover clues to how existing heart drugs work
8. Researchers unmask centuries-old elephant imposter
9. Virginia Tech researchers explore natural way to displace harmful germs from household plumbing
10. Penn researchers identify molecular link between gut microbes and intestinal health
11. Researchers Able to Identify that Benign Tumors from Use of Oral Contraceptive Have a Greater Chance of Becoming Malignant
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... BELL, Pa. , July 2, 2014  Unisys Corporation,s ... Netherlands , Unisys Nederland N.V., today announced that it ... to deliver, implement and manage a new Basic Provision Biometrics ... Unisys won the contract with a solution ... identity management software. The term of the contract is up ...
(Date:7/10/2014)... -- Research and Markets ( http://www.researchandmarkets.com/research/h7h8lq/gesture ) has ... Recognition & Touch-Less Sensing (2D, 3D, Ultrasonic, IR, ... to their offering http://photos.prnewswire.com/prnh/20130307/600769 ... Sensing Market to Grow Exponentially. Touch-less sensing applications ... companies were unable to leverage this technology due ...
(Date:7/10/2014)... 2014  Acuity Market Intelligence today released forecasts from "The ... that the global market for National Electronic ID (eID) programs ... During this time, the number of National eID cards in ... Asia , with its vast population, will dominate ... issued, while Europe trails a distant ...
Breaking Biology News(10 mins):Unisys Delivers New Basic Provision Biometrics Solution to Dutch Custodial Institutions Service 2Unisys Delivers New Basic Provision Biometrics Solution to Dutch Custodial Institutions Service 3Global Gesture Recognition & Touch-Less Sensing (2D, 3D, Ultrasonic, IR, Capacitive) Market - Forecasts to 2020 2National Electronic ID Programs Generate $54 Billion Between 2013 and 2018 with 3.5 Billion National eID Card Holders Worldwide 2
... Cichlid male nannies help out, especially if they,ve been ... Neolamprologus pulcher displays cooperative breeding behavior, where non-parents ... pair. Until now, it was assumed that male subordinates ... published Oct. 12, in the online journal PLoS ...
... available in French . Montreal, October ... funding to advance research in fields ranging from linguistics to ... Chairs were awarded to the following professors who are considered ... at Concordia in the presence of Senator Larry Smith and ...
... A team of investigators from the University of Utah has ... Health (NIH) to fund novel research that may help to ... form of multiple sclerosis. These studies will use an advanced ... who died of primary progressive multiple sclerosis. Multiple sclerosis ...
Cached Biology News:Recognition for 7 Concordia professors 2NIH grant will allow researchers to look for viral cause of most severe form of multiple sclerosis 2
(Date:7/10/2014)... Montreal, QC (PRWEB) July 10, 2014 ... comfort and convenience. This rejuvenating device now comes with a ... that develops over time. , The new cup is thinner ... This design works to target rough, thin and uneven surfaces ... original firm cup for a stimulating treatment on areas such ...
(Date:7/10/2014)... Ind. , July 10, 2014 /PRNewswire/ ... its use of capnography for respiratory monitoring ... group of healthcare leaders in embracing state-of-the-art ... how effectively patients are breathing and can ... occurs. By measuring the amount of carbon ...
(Date:7/10/2014)... -- Kainos Capital, a firm specializing in acquiring and managing ... acquired the Slim-Fast brand from Unilever. Unilever will retain ... transaction were not disclosed. Slim-Fast is a ... ready-to-drink shakes, powders, bars and snacks to retail customers ... the United Kingdom and Ireland.  ...
(Date:7/10/2014)... , July 10, 2014 Research ... addition of the "International Photonic Integrated Circuit ... Forecasts to 2019" report to their offering. ... The concept of photonic integration traces its ... century. The promise of photonic integration went unexplored ...
Breaking Biology Technology:Introducing a New Bonus Treatment Cup for EvoDerma’s NOOME Anti-Aging Motion 2Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2Kainos Capital Acquires Slim-Fast From Unilever 2International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2
... Inc. (OTC Bulletin Board: AIDA) today announced that it,has ... 30, 2007. Net,revenues totaled $7,373,770 for the quarter ended ... 2006. Gross profit decreased by 2.66% due to an,increase ... Aida,s,transfusion and injection forms of etimicin sulfate increased markedly.,Gross ...
... DURHAM, N.C., Nov. 15 AlphaMed Press, publisher ... Phinney and Miodrag Stojkovic as,co-editors. Curt I. ... years of,unprecedented growth in areas of the journal,s ... and number of manuscripts,submitted. During his tenure as ...
... PALO ALTO, Calif., Nov. 15 Jazz,Pharmaceuticals, Inc. ... Myers, the,company,s President, will provide a corporate presentation ... in New York, NY on,November 28, 2007 at ... of the presentation may be accessed by visiting ...
Cached Biology Technology:Aida Files 10Q 2Aida Files 10Q 3Aida Files 10Q 4STEM CELLS Journal Names Co-Editors 2
... R offers maximum application versatility for ... and cooling. Its active heating/cooling function ... temperature control ranges. Five different thermoblocks, ... test tubes, are available for: 0.5 ...
... Dot Blot Kits overcome this limitation and ... a wide range in low-density protein array ... They are ideal for performing reverse-phase protein ... for the presence of low abundant antigens. ...
... high quality microarray scanner based on patented confocal ... spatial resolution. The DNAscope LM is unique ... scanner that is upgradeable to a total of ... Includes control module (computer), monitor, and ...
... DetectorTM Microarray Dot Blot Kits overcome this ... quantitation over a wide range in low-density ... detection. They are ideal for performing ... of samples for the presence of low ...
Biology Products: