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UM scientists demonstrate role of RNA polymerase in gene transcription
Date:7/15/2010

that allows the polymerase access to the exposed DNA sequence to begin transcription. The DNA molecule then bends to relieve stress produced by the opening.

Dr. Jie Chen, who conducted this research while a graduate student in the Chemical Physics program, simulated the transcription bubble formation using a Brownian dynamics-based computer model developed by Dr. Thirumalai's laboratory. "By creating this molecular movie, we can look at the dynamics of RNAP and simulate how it shifts from one structure to another structure," explains Chen. "Our simulation confirms experimental observations, and goes further to establish a clear and active role for RNA polymerase."

Dr. Thirumalai's research group is continuing to study RNA polymerase by looking at the second phase of the transcription process in bacteria and also through models of human transcription.


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Contact: Kelly Blake
kellyb@umd.edu
University of Maryland
Source:Eurekalert

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