Navigation Links
UM scientists create fruit fly model to help unravel genetics of human diabetes
Date:11/2/2009

College Park, Md -- As rates of obesity, diabetes, and related disorders have reached epidemic proportions in the US in recent years, scientists are working from many angles to pinpoint the causes and contributing factors involved in this public health crisis. While sedentary lifestyles and diets high in sugar and fat contribute significantly to the rise in diabetes rates, genetic factors may make some people more vulnerable than others to developing diabetes.

Researchers at the University of Maryland are using the fruit fly, Drosophila melanogaster, as a model system to unravel what genes and gene pathways are involved in the metabolic changes that lead to insulin resistance and full-blown diabetes in humans. In research published in the Proceedings of the National Academy of Sciences (November 2, 2009), Leslie Pick, associate professor, department of entomology, and colleagues describe how they altered genes in fruit flies to model the loss of insulin production, as seen in human Type 1 diabetes.

"These mutant flies show symptoms that look very similar to human diabetes," explains Dr. Pick. "They have the hallmark characteristic which is elevated blood sugar levels. They are also lethargic and appear to be breaking down their fat tissue to get energy, even while they are eating a situation in which normal animals would be storing fat, not breaking it down."

Pick and her team, which included UM researchers Dr. Hua Zhang, Dr. Jingnan Liu, and Ms. Caroline Li, Associate Professor Bahram Momen (Biostatistics and Environmental Science), and former Johns Hopkins University Associate Professor Dr. Ronald Kohanski, used genetic approaches to delete a cluster of five genes encoding insulin-like peptides (Drosophila insulin-like peptides, DILPs) in the Drosophila melanogaster fruit fly. "When we compare the mutants with a normal fly that has been starved, they look the same in that they are both breaking down
'/>"/>

Contact: Kelly Blake
kellyb@umd.edu
301-405-8203
University of Maryland
Source:Eurekalert  

Page: 1 2

Related biology news :

1. USU scientists report major advance in human antibody therapy against deadly Nipah virus
2. Scientists discover influenzas Achilles heel: Antioxidants
3. EPAs new green parking lot allows scientists to study permeable surfaces that may help the environment
4. Scientists are first to observe the global motions of an enzyme copying DNA
5. Boston University scientists first to see RNA network in live bacterial cells
6. Scientists create NICE solution to pneumonia vaccine testing problems
7. Scientists of the UGR obtain a bioinsecticide to control the Mediterranean fruit fly
8. Queens scientists on international team discover ecologically unique changes in Arctic lake
9. UF scientists discover new explanation for controversial old patient-care technique
10. UF receives $12.2 million to establish national network of scientists
11. Caltech scientists create robot surrogate for blind persons in testing visual prostheses
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UM scientists create fruit fly model to help unravel genetics of human diabetes
(Date:7/25/2014)... (July 24, 2014)The link between autism and disrupted ... puzzle of the disease, and is largely unknown. ... Autism Research Initiative (SFARI), George Washington University (GW) ... offer truly integrative and in-depth answers to these ... , LaMantia, professor of pharmacology and physiology ...
(Date:7/25/2014)... from 25 countries and 35 states will attend ... Genetics Society of America (GSA) next week at ... will feature close to 500 presentations (including 70 ... gene expression and regulation, functional genomics, chemical biology ... a variety of diseases. , Of special ...
(Date:7/25/2014)... increasingly consume the healthcare community and remain ... , To address the worldwide crisis of ... countries, global leaders in diabetes, epidemiology and ... prevention and development of diverse intervention programs ... , This book on "Global Health Perspectives ...
Breaking Biology News(10 mins):GW researcher receives grant to answer the how and why of autism during development 2Yeast meeting to showcase latest breakthroughs in genetics and molecular biology 2What constitutes an effective response to the global 'diabesity' tsunami? 2
... available in French . , Researchers at McGill ... Jewish General Hospital along with colleagues at the University ... a significant breakthrough in the use of viruses to target ... Their results were published in the September early edition of ...
... Research today announced that Stuart A. Lipton, M.D., Ph.D., ... Aging, and Stem Cell Research Center at Burnham has ... a Center for Neurodegeneration Science (CNS). The center will ... the center comes from the National Institute of Environmental ...
... Innes Centre and the Central Science Laboratory could help ... stress and climate change. The research also shows that ... the climate. "While many compounds have been reported ... have identified how such compounds change in crops under ...
Cached Biology News:Viral 'magic bullet' targets cancer cells with help of new compound 2Burnham researcher awarded $8 million grant 2
(Date:7/25/2014)... MA -- Trillions of bacteria live in each person,s ... help digest food and stave off harmful infections, but ... , To help shed light on the role of ... associate professor Eric Alm recently tracked fluctuations in the ... year. The findings, described in the July 25 issue ...
(Date:7/25/2014)... (PRWEB) July 25, 2014 The Conferee ... for Topics for Conferee Networking. These two-hour sessions provide ... to meet and resolve problems, discuss new techniques, or ... deadline to submit a topic for consideration is August ... pittcon.org . The Conferee Networking committee will review the ...
(Date:7/25/2014)... Sinovac Biotech Ltd. (Nasdaq: SVA ), a leading ... today announced that it will release its unaudited financial results ... close on Thursday, August 14, 2014 EDT. The Company will ... Friday, August 15, 2014, at 8:00 a.m. EDT (Friday, August ... the Company,s financial results and provide an update on recent ...
(Date:7/24/2014)... , July 24, 2014  Asterias Biotherapeutics, Inc. ... emerging field of regenerative medicine, announced today that ... presentation to investors on Tuesday, July 29, 2014, ... presentation will include an overview of Asterias, business ... webcast, visit http://www.ustream.tv/channel/asterias-biotherapeutics at least 15 ...
Breaking Biology Technology:Monitoring the rise and fall of the microbiome 2Monitoring the rise and fall of the microbiome 3Pittcon 2015 Announces Call for Topics for Conferee Networking Sessions 2Sinovac to Host Conference Call to Report Second Quarter 2014 Unaudited Financial Results 2Asterias Biotherapeutics Announces Live Investor Webcast 2Asterias Biotherapeutics Announces Live Investor Webcast 3Asterias Biotherapeutics Announces Live Investor Webcast 4
... S.C., April 23 Signalife, Inc.,(Amex: SGN ... and Trademark,Office has awarded the Company a new ... Monitoring Heartbeats Of A Patient". The patent, which,covers ... develop new,proprietary products., Patent attorneys from Fulwider ...
... Novel Nucleoside Analogue; New ... CEO and Directors Appointed, ... announced today that on April 18, 2008 it acquired,Virium Pharmaceuticals ... with a portfolio of,clinical stage product candidates focused in oncology, ...
... Champions,Biotechnology, Inc. (OTC Bulletin Board: CSBR), a company ... tumor specific data to,enhance the value of oncology ... financing. Under the terms of the private investment,Champions ... stock at $1.75 per share. There were no ...
Cached Biology Technology:Signalife Awarded New U.S. Patent, 'System For, And Method Of, Monitoring Heartbeats Of A Patient' 2MacroChem Acquires Virium Pharmaceuticals 2MacroChem Acquires Virium Pharmaceuticals 3MacroChem Acquires Virium Pharmaceuticals 4MacroChem Acquires Virium Pharmaceuticals 5Champions Biotechnology, Inc. Completes $2,500,000 Private Financing at $1.75 per Share 2Champions Biotechnology, Inc. Completes $2,500,000 Private Financing at $1.75 per Share 3
Water Distilled (Gibco™) is membrane filtered and endotoxin screened....
Immunogen: Human Respiratory Syncytial Virus (RSV) and Bovine Respiratory Syncytial Virus (BRSV) Fusion protein Storage: -20 C, Avoid Freeze/Thaw Cycles...
Mus musculus MARCKS-like protein, mRNA...
... HandyStep electronic from BRAND adds ergonomics ... is the only electronic, motor-driven repeating ... tips, including BRAND PD-Tip syringe tips, ... Dispenser Tips,and VWRbrand Combi-Syringes. Select virtually ...
Biology Products: