Navigation Links
UM researchers find new marker to identify cancer stem cells
Date:12/3/2007

to detect the ALDH activity in the cells. Cells with high levels of this enzyme become fluorescent and can be detected. Cells can then be sorted to pull out the stained cells.

When they did this, researchers found that the ALDEFLUOR-positive cells acted like stem cells, while the ALDEFLUOR-negative cells did not. Stem cells are defined by their ability to generate identical cells as well as to differentiate into other types of cells.

The study also tested whether the separated cells could produce a breast tumor. Tumors formed only from the ALDEFLUOR-positive cells, even when as few as 500 cells were used. On the other hand, 50,000 ALDEFLUOR-negative cells did not generate tumors.

In addition to identifying the stem cells, the researchers found ALDH1 can indicate how aggressive a tumor is. In tissue samples from 577 patients with breast cancer, those bearing ALDH1-positive tumors had lower overall survival and were 1.76 times more likely to develop metastases than patients with ALDH1-negative tumors. ALDH1 was expressed in 19 percent to 30 percent of the tumors.

The ALDH1 marker correlates with more aggressive tumors, possibly reflecting a different rate of renewal of cancer stem cells in these cancers. Its possible to use ALDH1 in association with other markers as a prognostic marker to help determine what treatment is necessary. More research is needed, though, before we can apply these findings in the clinic, Dontu says.

While this work was done specifically in breast cancer, the researchers believe it could have implications for other cancer types. U-M researchers are actively involved in stem cell research in virtually all cancer types. In addition to the initial breast cancer stem cell discovery, U-M researchers have been the first to identify stem cells in pancreatic and head and neck cancers. Work is ongoing to develop and test treatments that target these cells.

The lessons weve learned from breast cance
'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... (almonds, Brazil nuts, cashews, hazelnuts, macadamias, pecans, pine nuts, ... publications, British Medical Journal Open (BMJ Open) ... BMJ Open article looked at the effects of ... that tree nut consumption resulted in a significant decrease ... ONE article focused on the effect of tree ...
(Date:7/30/2014)... regulate its genes, and adapt to changes in its ... regulation taking place in the truffle, is published in ... illustrates how the truffle deals with its complex genome,s ... may shed light on how traits like aroma and ... known as Prigord truffles, have a syrupy sweet flavor ...
(Date:7/30/2014)... until they hatched 4.5 years later, according to a ... PLOS ONE by Bruce Robison from Monterey ... have a single reproductive period during their life, where ... eggs until they hatch. Shallow-water octopuses typically care for ... is known about the brooding of deep-sea species. Using ...
Breaking Biology News(10 mins):New international tree nut council study looks at nuts, diabetes and metabolic syndrome 2How black truffles deal with the jumpers in their genome 2Deep-sea octopus has longest-known egg-brooding period 2
... nanotechnology fanciers suggest that, like proverbial birds of ... or clump together. This tendency, they ... manufacturing increases and the number of nanotechnology-enabled products ... Maynard, chief science advisor to the Project on ...
... completing the first large-scale report sequencing breast and colon ... studied the vast majority of protein-coding genes which now ... mutated in relatively few cancers. Their report, published ... indicates that while little is known about these less-commonly ...
... a reality today, but how can we find out about ... a full record of the Earths climate for several hundred ... that can be taken to the lab for analysis. Incredibly, ... Antarctic regions, and a European Science Foundation programme has a ...
Cached Biology News:Nanoparticle exposures happen, says expert 2Genome update defines landscape of breast and colon cancers 2Genome update defines landscape of breast and colon cancers 3European lead in reading past climates from ice cores 2European lead in reading past climates from ice cores 3
(Date:7/31/2014)... Indiana University Bloomington have described the self-assembly of ... with potential value for the field of organic ... cells. , Their paper, "Anion-Induced Dimerization of 5-fold ... Self-Assembled Crystals," has been published online by ... Society of Chemistry. It is the first collaboration ...
(Date:7/31/2014)... , July 31, 2014 According ... Research "Quantum Dots Market - Global Industry Analysis, Size, ... market was valued at USD 88.5 million in 2011, ... 2023, growing at a CAGR of 53.8% from 2013 ... Market Report at  http://www.transparencymarketresearch.com/quantum-dots.html Increasing demand ...
(Date:7/31/2014)... NY (PRWEB) July 31, 2014 Graphite ... in high temperature oven carts. These bearings are uniquely ... in sealed ball bearings because of the high ... alumina requested help from the design engineers at Graphite ... a heating process. During their manufacturing operation, pans containing ...
(Date:7/31/2014)... York , July 31, 2014 ... Transparency Market Research "Electrodes for Medical Devices Market (Diagnostic ... Electrodes, Therapeutic Electrodes - TENS, Pacemakers, Defibrillators, Electrosurgical and ... Trends and Forecast, 2013 - 2019," the global electrodes ... million in 2012 and is estimated to reach a ...
Breaking Biology Technology:Chemists demonstrate 'bricks-and-mortar' assembly of new molecular structures 2Chemists demonstrate 'bricks-and-mortar' assembly of new molecular structures 3Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 2Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 3Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 4Graphite Metallizing Announces Bearings for High Temperature Oven Applications 2Graphite Metallizing Announces Bearings for High Temperature Oven Applications 3Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 2Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 3Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 4Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 5Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 6
... J. Samskog, H. Wadensten, and J. Flensburg ... Sweden , , ... analyse phosphopeptides in mouse brain tissue. The trypsin-digested tissue was separated ... using Ettan MDLC. The detection was performed by mass spectrometry using ...
... Key words: SPA Imaging Beads ... , SPA Imaging Assays ... an SPA Imaging Bead in order to generate a signal. Polystyrene (PS) ... rabbit secondary antibodies during the assay. The Donkey Anti-Rabbit PS SPA Imaging ...
... , ... Imaging Beads , ... (CGRP) is believed to have an important physiological role in the central ... basilar arteries, in vitro studies have identified a number of ...
Cached Biology Technology:Sensitive identification of phosphopeptides in brain tissue using Ettan MDLC and Finnigan LTQ 2Sensitive identification of phosphopeptides in brain tissue using Ettan MDLC and Finnigan LTQ 3Sensitive identification of phosphopeptides in brain tissue using Ettan MDLC and Finnigan LTQ 4Utilization of Donkey Anti-Rabbit PS SPA Imaging Beads in the quantitative measurement of cAMP in cells 2Utilization of Donkey Anti-Rabbit PS SPA Imaging Beads in the quantitative measurement of cAMP in cells 3Utilization of Donkey Anti-Rabbit PS SPA Imaging Beads in the quantitative measurement of cAMP in cells 4The development of a calcitonin-gene related peptide (CGRP) receptor-binding assay using the LEADseeker Multimodality Imaging System 2The development of a calcitonin-gene related peptide (CGRP) receptor-binding assay using the LEADseeker Multimodality Imaging System 3The development of a calcitonin-gene related peptide (CGRP) receptor-binding assay using the LEADseeker Multimodality Imaging System 4The development of a calcitonin-gene related peptide (CGRP) receptor-binding assay using the LEADseeker Multimodality Imaging System 5
HRP Monoclonal-Goat Diluent - 5X Concentrate, 25 mL...
Rabbit anti-Junctophilin-4 (C-term)...
... CopyControl™ PCR Cloning Kits are designed to speed ... that all PCR products, regardless of sequence or ... PCR products including those that are difficult to ... may be unstable or code for potentially detrimental ...
Size & Applications: 20 ml Storage Temp.: -20C Shelf Life: 12 months ...
Biology Products: