Navigation Links
UM researchers find new marker to identify cancer stem cells
Date:12/3/2007

ANN ARBOR, Mich. Researchers at the University of Michigan Comprehensive Cancer Center have found a marker that can be used to identify stem cells in breast tumors, suggesting a potential simple test that could help determine the best treatment for breast cancer.

The finding also provides strong support for the hypothesis that a small number of cells, called cancer stem cells, are responsible for fueling a tumors growth.

U-M researchers were the first to discover stem cells in a solid tumor, finding them first in breast cancer. Generally, stem cells make up fewer than 5 percent of all the cells in a tumor, but they may be the key cells in cancer progression. The process of looking at the cell surface to identify stem cells, however, is too complex to apply to patient care.

In the new study, published in the November issue of Cell Stem Cell, the researchers found that cells from normal and cancerous breast tissue that had high levels of the enzyme aldehyde dehydrogenase activity, or ALDH, acted like breast stem cells. Further, of 577 human breast cancer tissue samples studied, those that expressed the specific form ALDH1 had the worst outcomes, suggesting this easily detected marker could be used to assess prognosis.

This study is a big step because it provides a marker thats easy to use in both normal and cancer cells. Clinical applications were really not possible with the previously described markers. The fact that ALDH1 was identified in stem/progenitor cells from both normal and cancer tissue lends support to the idea that those cells are the primary target of transformation to malignancy. We believe it is only a very small population of cells that really are capable of unlimited growth and therefore drive cancer recurrence and metastasis, says senior study author Gabriela Dontu, M.D., Ph.D., research assistant professor of internal medicine at the U-M Medical School.

Researchers used a reagent called ALDEFLUOR
'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/4/2014)... Fla. (November 4, 2014) — Think about the way ... How do neighboring cells know that they are supposed ... how do these tissues find the correct place and ... answering these crucial questions. , In a new study, ... to communicate with their surrounding neighbors, at the head-trunk ...
(Date:11/4/2014)... 2014   Neurotechnology , a provider of ... latest version of its fingerprint matching algorithm has ... evaluation organized by NIST. The MINEX test ... INCITS 378 fingerprint standard template format. MINEX compliance ... in the United States ...
(Date:11/3/2014)... that low birth weight and preterm birth are linked ... adulthood. Findings published in the American College of Rheumatology ... that low birth weight and pre-term babies were not ... as adults. , According to the ACR, 27 ... with clinical OA. Symptoms of OA range from mild ...
Breaking Biology News(10 mins):The inside story: How the brain and skull stay together 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 3Preterm, low birth-weight babies may need new hips in adulthood 2
... WHAT: The Office of Dietary Supplements (ODS) ... release of the ninth issue of the Annual Bibliography ... selected for the 2007 Bibliography include research supported by ... partnerships. The research covers a wide array of ...
... at least four times more prevalent in the atmosphere ... at Scripps Institution of Oceanography at UC San Diego. ... by Scripps geochemistry professor Ray Weiss made the first ... of times more effective at warming the atmosphere than ...
... drinking water and stable habitats. But biodiversity is currently ... around the world causes profound changes in our environment ... services they provide. To better understand the role of ... it, its basics must be studied more fully. This ...
Cached Biology News:Annual Bibliography of Significant Advances in Dietary Supplement Research 2007 2Potent greenhouse gas more prevalent in atmosphere than previously assumed 2Potent greenhouse gas more prevalent in atmosphere than previously assumed 3DFG continues to strengthen biodiversity research 2
(Date:11/24/2014)... 24, 2014   ...   Elsevier , a world-leading provider of ... to announce the launch of the latest title in the ... Opinion in Food Science . ... with a new platform to keep up-to-date with the expanding ...
(Date:11/24/2014)... USA (PRWEB) November 23, 2014 One of ... field of optics and photonics is now available to high ... very low cost. SPIE, the international society for optics ... to the complete SPIE Digital Library available to ... price. , “Light-based technologies are integral to all areas of ...
(Date:11/24/2014)... 2014 Deep Research Report on Global ... and in-depth research report on the Adipic Dihydrazide ... definition, classification, application, and industry chain structure as ... international market analysis, including China’s domestic market as ... Asia, China, Japan etc. regions) industry analysis covering ...
(Date:11/24/2014)... 2014  Spherix Incorporated (Nasdaq: SPEX ... fostering and monetization of intellectual property, today provided ...  Case No. 3:13-cv-03494-M and  Spherix v. Uniden Corporation ... the United States District Court for the Northern ... On November 21, 2014 the Markman ...
Breaking Biology Technology:Elsevier Announces Launch of New Journal: Current Opinion in Food Science 2Elsevier Announces Launch of New Journal: Current Opinion in Food Science 3SPIE Digital Library Now Available to High Schools, Two-Year Colleges at No or Low Cost 2Adipic Dihydrazide Industry 2019 Research Forecasts on Worldwide, China Regions Now Available at ReportsnReports.com 2Adipic Dihydrazide Industry 2019 Research Forecasts on Worldwide, China Regions Now Available at ReportsnReports.com 3Markman Hearing Held as Scheduled in VTech and Uniden Cases 2
... planes to explore their limits, researchers at the ... probing the newest microscope technology to further improve ... are critical for setting standards and improving production ... new microscope technology uses helium ions to generate ...
... WASHINGTON The Food & Drug Administration (FDA) issued ... report acknowledged that nanoscale materials potentially could be used ... that those materials present challenges complicated by the fact ... change as size varies within the nanoscale. , ...
... only valuable if we possess it in large-sized pieces. ... for those interested in exploiting gold,s exceptional ability to ... oxidation of poisonous carbon monoxide (CO) into harmless carbon ... potentially improve the effectiveness of catalytic converters that clean ...
Cached Biology Technology:NIST studies how new helium ion microscope measures up 2Nanotechnology and the FDA: size matters 2NIST and partners identify tiny gold clusters as top-notch catalysts 2
... Features Convenient platform for tube handling and ... x 0.2ml V-bottom tubes - 96 ... - Thermo-Fast® 96 Non-Skirted Plate ... - 48 x 0.5ml Thermo-Tubes Multiple workstations can ...
... The Pro upgrade for Shimadzu Phoretix 2D, ... advanced statistical tools for comparative gel analysis ... Data base add on component ... (Oracle version 9i release 2 client software). ...
... systems provide linking and labelling reagents ... specific primary antibodies for visualising cellular ... accomplished using an ultra-sensitive indirect labelling ... technology. Secondary antibodies are polymerised directly ...
... Enzyme concentration - 5 units/µL ,• High ... yields ,• Leaves an 'A' overhang ,• ... which exhibits very high activity in primer ... ensure the quality of the enzyme, each ...
Biology Products: