Navigation Links
UIC study identifies a key molecular switch for telomere extension by telomerase
Date:11/23/2011

Researchers at the University of Illinois at Chicago College of Medicine describe for the first time a key target of DNA damage checkpoint enzymes that must be chemically modified to enable stable maintenance of chromosome ends by telomerase, an enzyme thought to play a key role in cancer and aging.

Their findings are reported online in Nature Structural and Molecular Biology.

Telomeres are the natural ends of chromosomes, consisting of specialized DNA-and-protein structures that protect chromosome ends and ensure faithful duplication of chromosomes in actively dividing cells. An essential player in telomere maintenance is an enzyme complex called telomerase. Without telomerase, telomeres become progressively shorter each time the cell divides.

If telomeres become too short, chromosome ends will be recognized as broken, prompting DNA-damage checkpoint proteins to halt cell division and DNA repair proteins to fuse or rearrange the chromosome ends. Telomere dysfunction has been linked to tumor formation and premature aging in humans.

The UIC study, led by Toru Nakamura, associate professor of biochemistry and molecular genetics, focused on understanding how two DNA-damage checkpoint enzymes called ATM and ATR contribute to the regulation of telomerase.

"Our current study found that ATM and ATR help to switch on the telomere complex by chemically modifying a specific target protein bound to telomeric DNA, which then attracts telomerase, much like honey bees are attracted if flowers open and show bright colors," Nakamura said.

The study was done in fission yeast cells, a model organism that utilizes very similar protein complexes as human cells do to maintain telomeres. Previous discoveries in fission yeast have provided key information that helped identify several key factors required in maintenance of human telomeres.

Nakamura thinks that a similar ATM/ATR-dependent molecular switch may exist i
'/>"/>

Contact: Jeanne Galatzer-Levy
jgala@uic.edu
312-996-1583
University of Illinois at Chicago
Source:Eurekalert

Page: 1 2

Related biology news :

1. Studying bat skulls, evolutionary biologists discover how species evolve
2. Genetic study confirms: First dogs came from East Asia
3. First study to reveal how paracetamol works could lead to less harmful pain relief medicines
4. New Study Shows Impact of Employee Wellness Efforts
5. New study identifies novel role for PEA-15 protein in cancer growth
6. UT Dallas research widens study of brains role in tinnitus
7. Study of flower petals shows evolution at the cellular level
8. Study explains how heart attack can lead to heart rupture
9. Study details links between climate, groundwater availability - will help states prepare for drought
10. Long-term study shows acid pollution in rain decreased with emissions
11. New study links excessive amounts of vitamin D to onset of atrial fibrillation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/10/2015)... -- Continuing its 167-year history of offering the Best, the ... Eye Scanning Password Authenticator , a device that confirms ... or sensitive data. Employing the same biometric ... device has a small camera that scans and saves ... them into an encrypted ID that cannot be forged ...
(Date:3/4/2015)... DUBLIN , Mar. 04, 2015 Research ... announced the addition of the "Global Biometrics ... their offering. The market for biometric ... CAGR of around 14% till 2020 ... will be increasing security needs, government projects and ...
(Date:2/25/2015)... 2015  ABC Financial Services (ABC), the leading ... and Fitness Industry, today announced enhancements to their ... latest upgrade includes advances to the agreement section ... via Identity One fingerprint biometrics. The features will ... displays at the International Health, Racquet & Sportsclub ...
Breaking Biology News(10 mins):Hammacher Schlemmer Introduces The Eye Scanning Password Authenticator 2Global Biometrics Market Forecast and Opportunities, 2020 2Global Biometrics Market Forecast and Opportunities, 2020 3ABC Financial Unveils New Software Enhancements 2ABC Financial Unveils New Software Enhancements 3
... a component of salt, are elevated in many urban streams ... government study. Chloride levels above the recommended federal criteria ... 40 percent of urban streams tested. The study was ... chloride can inhibit plant growth, impair reproduction, and reduce the ...
... 16th 2009 / b3c newswire / - NiKem Research ... the Italian Ministry of Health, GLP certification of its bioanalysis ... NiKem Research has provided for many years high quality cost-effective ... ADME(T) and in vivo PK services associated to ...
... including the University of Colorado at Boulder have sequenced ... species, providing information that can be used to better ... Identifying such DNA barcodes can help wildlife officials ... species are in sharp decline from illegal trade estimated ...
Cached Biology News:Chloride found at levels that can harm aquatic life in urban streams of the Northern US 2NiKem Research receives certification for GLP Bioanalysis 2CU-Boulder team identifies DNA "barcodes to help track illegal trading of wildlife products 2CU-Boulder team identifies DNA "barcodes to help track illegal trading of wildlife products 3
(Date:3/27/2015)... 27, 2015 Working in collaboration with ... London , Richmond Pharmacology is the first ... 3 study for an investigational RNAi therapeutic being developed for ... the nerves and heart. Read press release ... Based at St Georges University of London ...
(Date:3/26/2015)... 26, 2015  Roka Bioscience, Inc. (NASDAQ: ... providing advanced testing solutions for the detection of ... the three months and full year ended December ... Results:Revenue for the quarter ended December 31, 2014 ... fourth quarter of 2013 and $1.5 million for ...
(Date:3/26/2015)... 2015  BioNano Genomics, Inc., the leader in genome ... as chief commercial officer. Salyer has more than 20 ... in life sciences. At BioNano, Salyer will oversee the ... platform to assemble a comprehensive view of complex genomes ... 32 institutions located in the United States ...
(Date:3/26/2015)... 2015 ReliantHeart, Inc., an innovative supplier ... supplier of precision transit-time flow measurement solutions, are collaborating ... the efficiency of the HeartAssist5® Left Ventricular ... experience greater mobility and peace of mind. , ... board, will draw 1/6th of the power required by ...
Breaking Biology Technology:Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 2Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 3Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 4Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 5Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 6Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 7BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 2BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 3LVAD patients to have greater mobility and peace of mind through Transonic and ReliantHeart’s True Flow collaboration for the HeartAssist5® 2LVAD patients to have greater mobility and peace of mind through Transonic and ReliantHeart’s True Flow collaboration for the HeartAssist5® 3
... has purchased a LEAP 3000 metrology system made by ... Wis. The Tohoku University system is the third system Imago has ... system in conjunction with its representatives based in Japan, the Noah ... enabling metrology at the atomic scale. , , ...
... - In Victorian England, the game of croquet was ... matter, and people could share the latest news without inhibition. ... goal of a research team working from the University ... to capture that sense of interactivity and bring it to ...
... you noticed recently the earnest discussions about a seemingly inalienable ... maybe that overstates the argument a little bit, but the ... their blogging activities on what Apple considered competitive secrets is ... in various media. , ,Then in the not-quite-yet-news bin one ...
Cached Biology Technology:The Croquet Project: An open source solution to the OS monopoly 2The Croquet Project: An open source solution to the OS monopoly 3The Croquet Project: An open source solution to the OS monopoly 4The Croquet Project: An open source solution to the OS monopoly 5Social engineering - Coming to an IT ship near you? 2Social engineering - Coming to an IT ship near you? 3
... MBP Coated Microplate, 96 Well Anti-phospho-MBP, ... Magnesium/ATP Cocktail, #20-11 Blocking Buffer, 10X, ... LumiGLO™ Chemiluminescen Applications: ... Routinely evalauted by non-radioactive ...
... ActivePro In Vitro Translation ... E.coli lysate, synthesizes higher ... well as proteins with ... competing kits. This results ...
One-step, microplate or cuvet, colorimetric, detection range 0.3 g/dL to 5 g/dL. Procedure: 5 min....
The Varian 4000 GC/MS system offers three easily switchable ionization configurations: internal ionization (II), external ionization (EI) or hybrid chemical ionization (CI)...
Biology Products: