Navigation Links
UIC study identifies a key molecular switch for telomere extension by telomerase
Date:11/23/2011

Researchers at the University of Illinois at Chicago College of Medicine describe for the first time a key target of DNA damage checkpoint enzymes that must be chemically modified to enable stable maintenance of chromosome ends by telomerase, an enzyme thought to play a key role in cancer and aging.

Their findings are reported online in Nature Structural and Molecular Biology.

Telomeres are the natural ends of chromosomes, consisting of specialized DNA-and-protein structures that protect chromosome ends and ensure faithful duplication of chromosomes in actively dividing cells. An essential player in telomere maintenance is an enzyme complex called telomerase. Without telomerase, telomeres become progressively shorter each time the cell divides.

If telomeres become too short, chromosome ends will be recognized as broken, prompting DNA-damage checkpoint proteins to halt cell division and DNA repair proteins to fuse or rearrange the chromosome ends. Telomere dysfunction has been linked to tumor formation and premature aging in humans.

The UIC study, led by Toru Nakamura, associate professor of biochemistry and molecular genetics, focused on understanding how two DNA-damage checkpoint enzymes called ATM and ATR contribute to the regulation of telomerase.

"Our current study found that ATM and ATR help to switch on the telomere complex by chemically modifying a specific target protein bound to telomeric DNA, which then attracts telomerase, much like honey bees are attracted if flowers open and show bright colors," Nakamura said.

The study was done in fission yeast cells, a model organism that utilizes very similar protein complexes as human cells do to maintain telomeres. Previous discoveries in fission yeast have provided key information that helped identify several key factors required in maintenance of human telomeres.

Nakamura thinks that a similar ATM/ATR-dependent molecular switch may exist in human cells to regulate telomere maintenance. However, certain details of the protective complex regulation may be different, he noted.

Because deregulation of telomere maintenance mechanisms is a key event in tumor formation, understanding how cellular components collaborate to generate functional telomeres may be important to finding ways to prevent cancer, Nakamura said.


'/>"/>
Contact: Jeanne Galatzer-Levy
jgala@uic.edu
312-996-1583
University of Illinois at Chicago
Source:Eurekalert

Related biology news :

1. Studying bat skulls, evolutionary biologists discover how species evolve
2. Genetic study confirms: First dogs came from East Asia
3. First study to reveal how paracetamol works could lead to less harmful pain relief medicines
4. New Study Shows Impact of Employee Wellness Efforts
5. New study identifies novel role for PEA-15 protein in cancer growth
6. UT Dallas research widens study of brains role in tinnitus
7. Study of flower petals shows evolution at the cellular level
8. Study explains how heart attack can lead to heart rupture
9. Study details links between climate, groundwater availability - will help states prepare for drought
10. Long-term study shows acid pollution in rain decreased with emissions
11. New study links excessive amounts of vitamin D to onset of atrial fibrillation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/4/2017)... , April 4, 2017   EyeLock LLC , ... that the United States Patent and Trademark Office (USPTO) ... covers the linking of an iris image with a ... and represents the company,s 45 th issued patent. ... is very timely given the multi-modal biometric capabilities that ...
(Date:3/30/2017)... 2017 Trends, opportunities and forecast in this ... technology (fingerprint, AFIS, iris recognition, facial recognition, hand geometry, ... end use industry (government and law enforcement, commercial and ... and others), and by region ( North America ... Asia Pacific , and the Rest of the ...
(Date:3/24/2017)... The Controller General of Immigration from Maldives Mr. Mohamed Anwar ... prestigious international IAIR Award for the most innovative high security ePassport and ... ... Maldives Immigration Controller General, Mr. Mohamed ... the right) have received the IAIR award for the "Most innovative high ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... San Diego-based team building and cooking ... initiative announced today. The bold new look is part of a transformation to ... into a significant growth period. , It will also expand its service offering from ...
(Date:10/10/2017)... firm Parks Associates announced today that Tom Kerber , ... Meeting , October 11 in Scottsdale, Arizona . Kerber ... smart safety and security products impact the competitive landscape. ... Parks Associates: Smart Home Devices: Main Purchase Driver ... "The residential security market has experienced continued growth, and the introduction ...
(Date:10/9/2017)... DIEGO , Oct. 9, 2017  BioTech ... biological mechanism by which its ProCell stem cell ... critical limb ischemia.  The Company, demonstrated that treatment ... amount of limbs saved as compared to standard ... the molecule HGF resulted in reduction of therapeutic ...
(Date:10/9/2017)... San Antonio, Texas (PRWEB) , ... ... ... a new study published on October 5, 2017, in the medical journal, ... demonstrated equivalence with the gold standard, video EEG, in detecting generalized tonic-clonic ...
Breaking Biology Technology: