Navigation Links
UIC researchers make promising finding in severe lung disease
Date:6/29/2008

Researchers at the University of Illinois at Chicago have identified a novel function for an enzyme that plays a role in the tissue injury in acute respiratory distress syndrome, also known as ARDS.

The finding offers a new therapeutic target for the prevention and treatment of lung inflammation and injury. The research will be published in the journal Nature Immunology later this year and online June 29.

ARDS is an often fatal complication of bacterial infections, blood transfusions, overdoses of some medications, or traumatic injury. According to the National Heart, Lung, and Blood Institute, it affects nearly 150,000 people each year in the United States.

In ARDS, the lungs become swollen with water and protein, and breathing becomes impossible, leading to death in 30 percent to 40 percent of cases. There is no effective treatment.

It has previously been shown that the enzyme, called nonmuscle myosin light-chain kinase, or MYLK, plays a pivotal role in the disruption of the endothelial barrier -- a single thin layer of cells that line blood vessels -- which prevents water and protein from accumulating in tissues.

In addition to the disruption of the endothelial barrier and build-up of water in lungs in ARDS, a circulating blood cell, the neutrophil, "migrates into lung tissue and, when activated, can cause profound injury," said Jingsong Xu, assistant professor in pharmacology and dermatology and lead author of the paper.

Neutrophils are the most common type of white blood cells and are critical to what is called the innate immune response. They normally engulf and destroy invading bacteria and fungi and act as the first line of immune system defense.

In acute respiratory distress syndrome, they misfire and attack healthy tissue.

"Although there have been many studies into how MYLK disrupts the endothelial barrier, no one has investigated how MYLK functions to regulate the neutrophil transmigration into tissues," said Xu. "We decided to look at this."

The researchers found that MYLK was essential to the movement of neutrophils through the endothelial barrier. It unleashes a cascade of molecular events inside the neutrophil that changes the cell's shape, which is necessary for adhesion and migration.

"To our surprise, the pathway was a completely novel one that did not involve the well-studied and expected target of (the enzyme)," Xu said.

The unexpected finding of a novel pathway "opens up a completely new set of possible therapeutic targets for the prevention and treatment of this deadly disease," said Dr. Asrar Malik, distinguished professor, head of pharmacology and co-author on the paper.


'/>"/>

Contact: Jeanne Galatzer-Levy
jgala@uic.edu
312-996-1583
University of Illinois at Chicago
Source:Eurekalert

Related biology news :

1. Montana State researchers release guide to noninvasive carnivore research
2. Growth hormones link to starvation may be clue to increasing life span, researchers find
3. Researchers explain nitrogen paradox in forests
4. UNH researchers test sediment-scrubbing technology in NH river
5. Florida researchers receive JDRF Excellence in Clinical Research Award
6. LIAI researchers discover new cellular mechanism that will significantly advance vaccine development
7. Stem cell researchers give old muscle new pep
8. UT Southwestern researchers create molecule that nudges nerve stem cells to mature
9. Researchers reveal insights into hidden world of protein folding
10. U of M researchers discover gene linked to adult-onset obesity
11. Livermore researchers use carbon nanotubes for molecular transport
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/26/2016)... and LONDON , ... Finacle, part of EdgeVerve Systems, a product subsidiary ... Onegini today announced a partnership to integrate the ...      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ) ... provide their customers enhanced security to access and ...
(Date:4/15/2016)... , April 15, 2016  A new ... make more accurate underwriting decisions in a fraction ... timely, competitively priced and high-value life insurance policies ... screenings. With Force Diagnostics, rapid testing ... lifestyle data readings (blood pressure, weight, pulse, BMI, ...
(Date:4/13/2016)... 13, 2016  IMPOWER physicians supporting Medicaid patients in ... new clinical standard in telehealth thanks to a new ... higi platform, IMPOWER patients can routinely track key health ... mass index, and, when they opt in, share them ... to a local retail location at no cost. By ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... (PRWEB) , ... April 27, 2016 , ... ... Lamka, PhD to its Scientific Advisory Board. Dr. Lamka will assist PathSensors in ... pathogen detection. , PathSensors deploys the CANARY® test platform for the detection ...
(Date:4/27/2016)... 27, 2016 MedDay, a biotechnology company ... the appointment of Catherine Moukheibir as Chairman of its Board ... Jean Jacques Garaud , who contributed to the rapid ... immediately. Catherine started her career in strategy consulting ... London .  She held C-Suite level roles ...
(Date:4/26/2016)... ... April 26, 2016 , ... The European Patent Office ... as one of three finalists for the European Inventor Award 2016 in the category ... will be announced at a ceremony in Lisbon on June 9th. , The human ...
(Date:4/26/2016)... MD (PRWEB) , ... April 26, 2016 , ... ... a $1.8M Series A round of financing. Healthy investor interest drove significant oversubscription ... portfolio of generic biologics, known as biosimilars, to the advanced preclinical stages. , Chief ...
Breaking Biology Technology: