Navigation Links
UIC researchers make promising finding in severe lung disease
Date:6/29/2008

Researchers at the University of Illinois at Chicago have identified a novel function for an enzyme that plays a role in the tissue injury in acute respiratory distress syndrome, also known as ARDS.

The finding offers a new therapeutic target for the prevention and treatment of lung inflammation and injury. The research will be published in the journal Nature Immunology later this year and online June 29.

ARDS is an often fatal complication of bacterial infections, blood transfusions, overdoses of some medications, or traumatic injury. According to the National Heart, Lung, and Blood Institute, it affects nearly 150,000 people each year in the United States.

In ARDS, the lungs become swollen with water and protein, and breathing becomes impossible, leading to death in 30 percent to 40 percent of cases. There is no effective treatment.

It has previously been shown that the enzyme, called nonmuscle myosin light-chain kinase, or MYLK, plays a pivotal role in the disruption of the endothelial barrier -- a single thin layer of cells that line blood vessels -- which prevents water and protein from accumulating in tissues.

In addition to the disruption of the endothelial barrier and build-up of water in lungs in ARDS, a circulating blood cell, the neutrophil, "migrates into lung tissue and, when activated, can cause profound injury," said Jingsong Xu, assistant professor in pharmacology and dermatology and lead author of the paper.

Neutrophils are the most common type of white blood cells and are critical to what is called the innate immune response. They normally engulf and destroy invading bacteria and fungi and act as the first line of immune system defense.

In acute respiratory distress syndrome, they misfire and attack healthy tissue.

"Although there have been many studies into how MYLK disrupts the endothelial barrier, no one has investigated how MYLK functions to regulate the neut
'/>"/>

Contact: Jeanne Galatzer-Levy
jgala@uic.edu
312-996-1583
University of Illinois at Chicago
Source:Eurekalert

Page: 1 2

Related biology news :

1. Montana State researchers release guide to noninvasive carnivore research
2. Growth hormones link to starvation may be clue to increasing life span, researchers find
3. Researchers explain nitrogen paradox in forests
4. UNH researchers test sediment-scrubbing technology in NH river
5. Florida researchers receive JDRF Excellence in Clinical Research Award
6. LIAI researchers discover new cellular mechanism that will significantly advance vaccine development
7. Stem cell researchers give old muscle new pep
8. UT Southwestern researchers create molecule that nudges nerve stem cells to mature
9. Researchers reveal insights into hidden world of protein folding
10. U of M researchers discover gene linked to adult-onset obesity
11. Livermore researchers use carbon nanotubes for molecular transport
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2015)... and Markets ( http://www.researchandmarkets.com/research/lc9bnl/global_gesture ) has announced ... in Automotive Sector 2014-2018" report to their offering. ... market in Automotive Sector to grow at a CAGR ... recognition is the ability of a device to identify ... recognition technology can be 2D-based or 3D-based. It uses ...
(Date:3/24/2015)... Markets ( http://www.researchandmarkets.com/research/kvdtcw/face_and_voice ) has announced the addition of ... report to their offering. This report analyzes the ... the following Segments: Face Biometrics, and Voice Biometrics. The report provides ... Japan , Europe , ... Africa , and Latin America ...
(Date:3/23/2015)... March 23, 2015 SoundView Technology Group issues a ... NXTD ) Wocket smart wallet. SoundView was one of the ... their experience with the Wocket in multiple scenarios and outlets. ... Foods and other retailers, making both debit and credit card ... also says, "If the company meets their plans in 2015, ...
Breaking Biology News(10 mins):Global Gesture Recognition Market in Automotive Sector Report 2015 - Growing Number of Partnerships 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4
... Research Institute have identified specific molecules in the brain ... brain stem cells, which, when activated, can transform into ... findings are published online this week in the Proceedings ... An earlier paper (published in the May issue ...
... of niacin (vitamin B3) in the liver, which should provide ... HDL-cholesterol levels in the blood and thus lower the risk ... levels, the mechanism of how it works has been mysterious, ... production. Recent work had uncovered that a component of ATP ...
... America (ESA) will hold its 93rd Annual Meeting Aug. ... now open to the press. The meeting will include ... the theme, "Enhancing ecological thought by linking research and ... open the meeting on Sunday, Aug. 3 with his ...
Cached Biology News: Brain stem cells can be awakened, say Schepens scientists 2Ecological Society of America announces its 93rd Annual Meeting 2Ecological Society of America announces its 93rd Annual Meeting 3
(Date:4/30/2015)...  Asterias Biotherapeutics, Inc. (NYSE MKT: AST), a leading ... today announced that it will release first quarter financial ... the close of the U.S. financial markets. The Company ... May 7, 2015 at 4:30 p.m. Eastern / 1:30 ... developments. For both "listen-only" participants and those ...
(Date:4/30/2015)... (PRWEB) April 30, 2015 Available ... at http://www.lespausa.com , Phytomer’s DOUCEUR INTEMPORELLE ... and reactive skin while battling the weakening threat ... restorative cream is formulated with star ingredient GLYCOSEA, ... biotechnology in a complex of soothing minerals and ...
(Date:4/29/2015)... According to a new market research ... & Non-Portable), Component (Accelerometer, Proximity Probe, & Others), ... Mining, & Others), & Geography - Global Forecast ... reach $1,453.76 Million by 2020, at a CAGR ... and 92 figures spread through 205 pages and ...
(Date:4/29/2015)... April 29, 2015 Cambrex Corporation (NYSE: CBM ... released on Friday, May 1, 2015 before the market opens. ... Company will host a conference call to discuss the financial ... , Friday, May 1, 2015 at 8:30 ... 1-888-468-2440 for U.S.1-719-325-2454 for International  Passcode:  7993632 Dial-in Replay: ...
Breaking Biology Technology:Asterias Biotherapeutics to Report First Quarter Results on May 7, 2015 2Asterias Biotherapeutics to Report First Quarter Results on May 7, 2015 3Phytomer introduces DOUCEUR INTEMPORELLE Restorative Shield Cream 2Phytomer introduces DOUCEUR INTEMPORELLE Restorative Shield Cream 3Vibration Monitoring Equipment (Portable & Non-Portable) Market worth $1,453.76 Million by 2020 - New Report by MarketsandMarkets 2Vibration Monitoring Equipment (Portable & Non-Portable) Market worth $1,453.76 Million by 2020 - New Report by MarketsandMarkets 3Vibration Monitoring Equipment (Portable & Non-Portable) Market worth $1,453.76 Million by 2020 - New Report by MarketsandMarkets 4
... US Oncology, Inc ., the nation,s ... treatment and research network in the United States, ... quarter of fiscal 2010 on Thursday, Nov. 4. ... (Logo:   http://www.newscom.com/cgi-bin/prnh/20100517/DA06089LOGO ) A conference ...
... HONG KONG, Oct. 7 /PRNewswire-Asia-FirstCall/ -- China Cord ... CO ), the first and largest cord blood ... authorization of the stock repurchase program on September 15, ... for approximately US$1.6 million through October 6, 2010 at ...
... Dendreon Corporation (Nasdaq: DNDN ) today announced ... 3, 2010 at 4:30 p.m. ET to review third quarter ... be obtained as follows: Time: , 4:30 PM ... 2010Dial-in: , 1-866-730-5769 (domestic) or +1-857-350-1593 (international); conference ...
Cached Biology Technology:US Oncology to Report 2010 Third Quarter Operating Results 2China Cord Blood Corporation Updates Status Regarding Share Repurchase Program 2Dendreon to Host Conference Call on November 3rd to Announce Third Quarter Financial Results 2
Mouse monoclonal [6G11] to Cytohesin 1 + 2 ( Abpromise for all tested applications)....
HP 1 alpha Immunogen: Synthetic peptide between amino acids 1-100 of the human HP 1 alpha protein. Storage: -20 C, Avoid Freeze/Thaw Cycles...
... KLH-conjugated, synthetic peptide corresponding to ... mouse p19ARF. The epitope ... 62-75. Clone 5-C3-1. Quality ... immunoblot. Stability ...
Request Info...
Biology Products: