Navigation Links
UIC researchers make promising finding in severe lung disease
Date:6/29/2008

Researchers at the University of Illinois at Chicago have identified a novel function for an enzyme that plays a role in the tissue injury in acute respiratory distress syndrome, also known as ARDS.

The finding offers a new therapeutic target for the prevention and treatment of lung inflammation and injury. The research will be published in the journal Nature Immunology later this year and online June 29.

ARDS is an often fatal complication of bacterial infections, blood transfusions, overdoses of some medications, or traumatic injury. According to the National Heart, Lung, and Blood Institute, it affects nearly 150,000 people each year in the United States.

In ARDS, the lungs become swollen with water and protein, and breathing becomes impossible, leading to death in 30 percent to 40 percent of cases. There is no effective treatment.

It has previously been shown that the enzyme, called nonmuscle myosin light-chain kinase, or MYLK, plays a pivotal role in the disruption of the endothelial barrier -- a single thin layer of cells that line blood vessels -- which prevents water and protein from accumulating in tissues.

In addition to the disruption of the endothelial barrier and build-up of water in lungs in ARDS, a circulating blood cell, the neutrophil, "migrates into lung tissue and, when activated, can cause profound injury," said Jingsong Xu, assistant professor in pharmacology and dermatology and lead author of the paper.

Neutrophils are the most common type of white blood cells and are critical to what is called the innate immune response. They normally engulf and destroy invading bacteria and fungi and act as the first line of immune system defense.

In acute respiratory distress syndrome, they misfire and attack healthy tissue.

"Although there have been many studies into how MYLK disrupts the endothelial barrier, no one has investigated how MYLK functions to regulate the neutrophil transmigration into tissues," said Xu. "We decided to look at this."

The researchers found that MYLK was essential to the movement of neutrophils through the endothelial barrier. It unleashes a cascade of molecular events inside the neutrophil that changes the cell's shape, which is necessary for adhesion and migration.

"To our surprise, the pathway was a completely novel one that did not involve the well-studied and expected target of (the enzyme)," Xu said.

The unexpected finding of a novel pathway "opens up a completely new set of possible therapeutic targets for the prevention and treatment of this deadly disease," said Dr. Asrar Malik, distinguished professor, head of pharmacology and co-author on the paper.


'/>"/>

Contact: Jeanne Galatzer-Levy
jgala@uic.edu
312-996-1583
University of Illinois at Chicago
Source:Eurekalert

Related biology news :

1. Montana State researchers release guide to noninvasive carnivore research
2. Growth hormones link to starvation may be clue to increasing life span, researchers find
3. Researchers explain nitrogen paradox in forests
4. UNH researchers test sediment-scrubbing technology in NH river
5. Florida researchers receive JDRF Excellence in Clinical Research Award
6. LIAI researchers discover new cellular mechanism that will significantly advance vaccine development
7. Stem cell researchers give old muscle new pep
8. UT Southwestern researchers create molecule that nudges nerve stem cells to mature
9. Researchers reveal insights into hidden world of protein folding
10. U of M researchers discover gene linked to adult-onset obesity
11. Livermore researchers use carbon nanotubes for molecular transport
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... 2017 Biopharm Reports has carried out ... of nuclear magnetic resonance spectroscopy (NMR). This involved ... current practices, developments, trends and end-user plans over ... and opportunities. These areas include growth in the ... and innovation requirements, hyphenated NMR techniques, main suppliers ...
(Date:1/21/2017)... 20, 2017 Research and Markets has announced ... report to their offering. ... The global voice recognition biometrics market to grow ... The report covers the present scenario and the growth prospects ... the market size, the report considers the revenue generated from the ...
(Date:1/18/2017)...  In vitro diagnostic (IVD) companies were very active ... and Kalorama Information expects that trend to continue – ... Generally, uncertainty in reimbursement and healthcare reform in ... the acquisitions landscape. Instead of looking to buy technology, ... outside of their home country and also to increase ...
Breaking Biology News(10 mins):
(Date:2/15/2017)... Pharmaceuticals Inc. (Vanda) (NASDAQ: VNDA), today announced financial ... full year ended December 31, 2016. ... we continued to demonstrate strong growth in our ... said Mihael H. Polymeropoulos, M.D., Vanda,s President and ... 2017 milestones underscores Vanda,s commitment to bringing important ...
(Date:2/15/2017)... WARRINGTON, Pa. , Feb. 15, 2017 ... biotechnology company focused on developing aerosolized KL4 surfactant therapies ... webcast (including a slide presentation) at 8:00 AM EST ... the AEROSURF phase 2 clinical program, the recently announced ... business and development activities. To participate in ...
(Date:2/15/2017)... ... February 15, 2017 , ... ... a strategic partnership that puts Diameter Health technology in the hands of Lantana ... allows providers, exchanges, quality improvement and public health entities – all those mining ...
(Date:2/15/2017)... Feb. 15, 2017  Theravance Biopharma, Inc. (NASDAQ: ... announced that it will release financial results for the ... Monday, February 27, 2017. An accompanying ... on February 27, 2017. To participate in the live ... U.S., or (920) 663-6266 for international callers, using the ...
Breaking Biology Technology: