Navigation Links
UIC researchers find promising new targets for antibiotics
Date:8/30/2007

University of Illinois at Chicago researchers have identified new sites on the bacterial cell's protein-making machinery where antibiotics can be delivered to treat infections.

"The primary challenge of antibiotic therapy has been fighting infections caused by the pathogens which became resistant to antibiotics," says Alexander Mankin, professor and associate director of UIC's Center for Pharmaceutical Biotechnology and lead investigator of the study. "Not a single class of drugs has escaped the inevitable emergence of resistance."

At present, Mankin said, "the constant development of new drugs is the only available strategy to keep up with the ever-growing variety of antibiotic-resistant pathogens."

Mankin and his research team are looking for new vulnerable sites on bacteria where drugs can be delivered to fight the infections.

"First we need to find the target, and then the weapons can be developed," he said.

In the study, which is published in the Journal of Biological Chemistry, UIC researchers divided a ribosome -- the main apparatus within the cell that makes protein, and one of the best antibiotic targets -- into specific sections. Random genetic mutations were engineered in each area, and the researchers looked for those alterations that stopped the ribosome from making proteins.

Of the thousands of mutations tested, 77 were detrimental to the function of the ribosome. The regions where those mutations lie can be targeted by new antibiotics, which may be used to treat such diseases as tuberculosis and pneumonia, Mankin said.

"If we find drugs that can bind to these regions, they will likely kill the pathogenic cell," he said.

According to Mankin, the development of microbial genomics brought new hope for the development of antibiotics, but few successful drug candidates have been produced using this method.

An alternative approach is to "follow the lead of nature, and develop new drugs that act on the targets in the course of evolution."

"The ribosome is the perfect target," he said. "More than half of all known antibiotics arrest cell growth by interfering with the ribosomal functions and inhibiting protein synthesis. This is an innovative concept, targeting new sites in the ribosome."


'/>"/>
Contact: Sam Hostettler
samhos@uic.edu
312-355-2522
University of Illinois at Chicago
Source:Eurekalert

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. NYU researchers simulate molecular biological clock
5. Researchers reveal the infectious impact of salmon farms on wild salmon
6. Researchers identify target for cancer drugs
7. Vital step in cellular migration described by UCSD medical researchers
8. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
9. UCSD researchers maintain stem cells without contaminated animal feeder layers
10. Researchers discover molecule that causes secondary stroke
11. Researchers find missing genes of ancient organism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2019)... JUPITER, Fla. (PRWEB) , ... August 27, 2019 ... ... developments in life science and drug development. This episode is scheduled to broadcast ... will explore Debiopharm, a biopharmaceutical research, development, investment and manufacturing company. The show ...
(Date:8/23/2019)... (PRWEB) , ... August 22, 2019 , ... ... rebranding to Planet121 following their acquisition in June of 2018. Along with the ... and communications. , “Our goal was to create a cohesive brand that ...
(Date:8/21/2019)... ... August 20, 2019 , ... ... the second time since BioInformatics first fielded the survey in 2016. The ... Customer Experience , from BioInformatics, part of Science and Medicine Group. More than ...
Breaking Biology News(10 mins):
(Date:8/29/2019)... ... August 29, 2019 , ... Prof. Stephen R. Byrn ... in Africa program, which includes a master’s degree in biotechnology innovation and regulatory ... through 13th, 2019. Topics to be addressed include Manufacturing, Quality, Regulation, Devices, ...
(Date:8/25/2019)... ... August 23, 2019 , ... Authors Gopal Nayak ... the scientific research book “Impact of Biofield Treatment on Growth and Anatomical Characteristics ... Patchouli. , The book garnered No. 1 status on Amazon in several ...
(Date:8/15/2019)... ... , ... PathSensors announced today that Roger Lawrence has joined ... of Food Technologists (IFT) Board of Directors, Illinois Institute of Technology (IIT) Institute ... and Applied Nutrition (JIFSAN) Advisory Council and the University of Maryland College of ...
(Date:8/8/2019)... , ... August 08, 2019 , ... ... Agents for sales and service organizations, today announced that the company’s Studio ... Award for the IVA market . Inference will officially accept the award at ...
Breaking Biology Technology: