Navigation Links
UIC researchers find promising new targets for antibiotics
Date:8/30/2007

University of Illinois at Chicago researchers have identified new sites on the bacterial cell's protein-making machinery where antibiotics can be delivered to treat infections.

"The primary challenge of antibiotic therapy has been fighting infections caused by the pathogens which became resistant to antibiotics," says Alexander Mankin, professor and associate director of UIC's Center for Pharmaceutical Biotechnology and lead investigator of the study. "Not a single class of drugs has escaped the inevitable emergence of resistance."

At present, Mankin said, "the constant development of new drugs is the only available strategy to keep up with the ever-growing variety of antibiotic-resistant pathogens."

Mankin and his research team are looking for new vulnerable sites on bacteria where drugs can be delivered to fight the infections.

"First we need to find the target, and then the weapons can be developed," he said.

In the study, which is published in the Journal of Biological Chemistry, UIC researchers divided a ribosome -- the main apparatus within the cell that makes protein, and one of the best antibiotic targets -- into specific sections. Random genetic mutations were engineered in each area, and the researchers looked for those alterations that stopped the ribosome from making proteins.

Of the thousands of mutations tested, 77 were detrimental to the function of the ribosome. The regions where those mutations lie can be targeted by new antibiotics, which may be used to treat such diseases as tuberculosis and pneumonia, Mankin said.

"If we find drugs that can bind to these regions, they will likely kill the pathogenic cell," he said.

According to Mankin, the development of microbial genomics brought new hope for the development of antibiotics, but few successful drug candidates have been produced using this method.

An alternative approach is to "follow the lead of nature, and develop new drugs that act on the targets in the course of evolution."

"The ribosome is the perfect target," he said. "More than half of all known antibiotics arrest cell growth by interfering with the ribosomal functions and inhibiting protein synthesis. This is an innovative concept, targeting new sites in the ribosome."


'/>"/>
Contact: Sam Hostettler
samhos@uic.edu
312-355-2522
University of Illinois at Chicago
Source:Eurekalert

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. NYU researchers simulate molecular biological clock
5. Researchers reveal the infectious impact of salmon farms on wild salmon
6. Researchers identify target for cancer drugs
7. Vital step in cellular migration described by UCSD medical researchers
8. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
9. UCSD researchers maintain stem cells without contaminated animal feeder layers
10. Researchers discover molecule that causes secondary stroke
11. Researchers find missing genes of ancient organism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/31/2019)... ... May 30, 2019 , ... Join ... live webinar on Wednesday, June 19, 2019 at 1pm EDT where ... review teams, data management teams and contract research organizations (CROs) can improve collaboration, ...
(Date:5/23/2019)... , ... May 23, 2019 , ... Federal Publications Seminars, ... years, is pleased to announce the release of FPSOnline 2.0, an updated version of ... premier weeklong conferences , La Jolla Government Contracts Week, were given a “sneak ...
(Date:5/21/2019)... ... May 21, 2019 , ... Experiential tourism, a trend encompassing culinary travel, cultural ... several years. And according to a recent report by Skift, a media company ... more and more travelers are wanting their journeys to be authentic and unique, and ...
Breaking Biology News(10 mins):
(Date:5/31/2019)... ... May 30, 2019 , ... A ... an efficient delivery system for the sustained release of human placental stem cell ... system was able to deliver CM into the injured kidney, where it helped ...
(Date:5/15/2019)... ... May 16, 2019 , ... Emulsifiers are the magic ... beverage products rely on these ingredients to create stable quality food that can ... paradigm shift triggers food formulators to seek out alternatives for starches, gums and ...
(Date:5/7/2019)... Columbia (PRWEB) , ... May 06, 2019 , ... ... a go-to resource for the growing number of repositories being asked to store ... are grateful to the team of contributors who are world leaders, who have ...
(Date:5/2/2019)... ... 30, 2019 , ... The centuries old practice of brewing beer thrives today ... breweries, and even home brewing clubs scattered across the nation. , But proper ... mastered can produce a superb product. Students at South Dakota School of Mines ...
Breaking Biology Technology: