Navigation Links
UI researcher studies evolution on the molecular level
Date:12/13/2013

The theory of evolution suggests that present-day organisms evolved from earlier life forms.

At the molecular level, evolution reshaped some of the enzymes that help complete chemical processessuch as converting food into energyin humans and all other life forms.

Now a University of Iowa researcher and his colleagues describe the evolution of various forms of the enzyme "dihydrofolate reductase" as it occurred from bacteria to humans. Their paper, "Preservation of Protein Dynamics in Dihydrofolate Reductase Evolution," appears in the Dec. 13 issue of the Journal of Biological Chemistry.

Amnon Kohen, professor of chemistry in the UI College of Liberal Arts and Sciences and member of the Interdisciplinary Program in Molecular and Cellular Biology, and his collaborators used bioinformatics (genetic sequencing information), computer-based calculations, artificial mutagenesis (DNA modification), and kinetic measurements in their work. They studied "humanized" forms of an enzyme that originated with the common bacterium E. coli in order to relate the action of protein dynamics and catalysis to the process of enzyme evolution.

They found that enzyme dynamics evolved over millions of years to optimize a specific catalyzed reaction that occurs in humans.

"Enzymes are critical components of every living cell, and they catalyze almost all chemical reaction in life. We study how evolution occurred on the molecular level," Kohen says. "This study is an attempt to understand how evolution of the whole organism (for example from bacteria like E. coli to humans) is expressed on the molecular level.

"We chose a 'housekeeping' enzyme, which is present in almost all organisms and is critical to life. That enzyme is called dihydrofolate reductase and is involved in DNA biosynthesis and all cells' replication," he says.

He says the researchers "bridged" between the bacterial and human enzymes by pro
'/>"/>

Contact: Gary Galluzzo
gary-galluzzo@uiowa.edu
319-384-0009
University of Iowa
Source:Eurekalert

Page: 1 2

Related biology news :

1. New organization brings together top researchers to sequence genomes of invertebrates
2. Bonefish spawning behavior in the Bahamas surprises researchers, should aid conservation
3. Where water is limited, researchers determine how much water is enough
4. Researchers at Penn help develop a dynamic model of tissue failure
5. Leibniz Prizes 2014: DFG honors 11 outstanding researchers
6. Researchers named to National Academy of Inventors
7. Researchers at Penn show optimal framework for heartbeats
8. University researchers observe surprising bonefish spawning behavior in the Bahamas
9. ASU researchers discover chameleons use colorful language to communicate
10. Canadian researchers lead groundbreaking discovery in deadly childhood cancer
11. Mount Sinai researchers say new strain of bird flu packs a punch even after becoming drug-resistant
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/16/2014)... -- NXT-ID, Inc. (NASDAQ: NXTD and ... focused on the growing mobile commerce market announces that ... Smart Wallet, at the 13 th annual Future ... conference on the intersection of technology and the economy. ... founder and publisher of the Strategic News Service™, the ...
(Date:10/15/2014)... our ability to assess the pandemic risk from strains ... we must not allow ourselves to become complacent that ... international consortium of scientists. , Influenza pandemics arise when ... yet to develop widespread immunity – spreads in the ... the past 100 years, the worst of which – ...
(Date:10/15/2014)... Gauß-Allianz has admitted Johannes Gutenberg University Mainz (JGU) ... science hub continues to maintain a significant nationwide ... , "The acceptance of Johannes Gutenberg University Mainz ... a milestone in the national and international competition ... state of Rhineland-Palatinate can be proud that Mainz ...
Breaking Biology News(10 mins):NXT-ID Inc. to Present at 13th Annual FiRe Conference 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 3Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3
... in Nature , researchers at Brandeis University and the ... time shed light on a crucial step in the complex ... in the human cell and frequently at which point genetic ... they were able to crystallize a very large complex of ...
... does inflammation, brought on by stress, affect aging? What can ... crisis of an epidemic of neurologic diseases caused by a ... keep a rosy outlook in the face of inevitable decline? ... host of other questions are the focus of the inaugural ...
... Hughes Medical Research Institute today announced that two researchers ... scientists nationwide to be appointed HHMI Early Career Scientists. ... of the Center,s Basic Sciences Division, and Toshiyasu Taniguchi, ... Biology and Public Health Sciences divisions, each will receive ...
Cached Biology News:A splice of life 2Living long, living well 2Two Hutchinson Center researchers named HHMI Early Career Scientists 2
(Date:10/20/2014)... The report “Pharmacy Automation Systems Market by ... Systems, Table-top Counters) by End-user (Inpatient Pharmacy Automation, ... to 2019” analyzes and studies the major market ... Asia-Pacific, and the Rest of the World (RoW). ... spread through 300 pages and in-depth TOC on ...
(Date:10/20/2014)... - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the Company") today announced ... $5.8 million and provides a good start to Q4.  The orders ... and one in the Middle East ... levels," said Peter Bruijns , President & CEO. "Total bidding ... than they have been for any complete year since the company ...
(Date:10/20/2014)... October 20, 2014 OncLive® ... Kimmel Cancer Center at Thomas Jefferson University has ... Through the Strategic Alliance Partnership program, the Sidney ... collaborate to raise awareness of the Center’s cutting-edge ... other projects. Clinicians and other health care professionals ...
(Date:10/19/2014)... October 20, 2014 OCTOBER ... Meeting (ABIM). ABIM will take place ... information about ABIM 2014 is now available ... Delegates representing companies and organizations from all ... obtain information on the latest products and ...
Breaking Biology Technology:Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 2Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 3Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 4Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 3
... , ORANGE COUNTY, Calif., July 27 ... Board of Directors declared a quarterly dividend payout of seventeen cents ($0.17) ... all stockholders of record on August 10, 2009. This payout represents ... (Logo: http://www.newscom.com/cgi-bin/prnh/20031202/BECLOGO ) , , Beckman Coulter, Inc., ...
... , , , ... Calif. and LONDON, July 27 Amgen (Nasdaq: AMGN ... companies will share commercialization of Amgen,s monoclonal antibody denosumab for postmenopausal ... product is approved in these countries. Amgen will commercialize the ...
... , , , ... ZMH ; SWX: ZMH) today announced the launch of ... with teaching surgeons and subject matter experts to develop a unique ... Training and Surgeon-to-Surgeon programs under one, consolidated service offering, the enhanced ...
Cached Biology Technology:Amgen to Collaborate With GlaxoSmithKline to Commercialize Denosumab in Europe for Postmenopausal Osteoporosis (PMO) 2Amgen to Collaborate With GlaxoSmithKline to Commercialize Denosumab in Europe for Postmenopausal Osteoporosis (PMO) 3Amgen to Collaborate With GlaxoSmithKline to Commercialize Denosumab in Europe for Postmenopausal Osteoporosis (PMO) 4Amgen to Collaborate With GlaxoSmithKline to Commercialize Denosumab in Europe for Postmenopausal Osteoporosis (PMO) 5Amgen to Collaborate With GlaxoSmithKline to Commercialize Denosumab in Europe for Postmenopausal Osteoporosis (PMO) 6Amgen to Collaborate With GlaxoSmithKline to Commercialize Denosumab in Europe for Postmenopausal Osteoporosis (PMO) 7Zimmer Launches New Medical Education and BioSkills Training Program 2Zimmer Launches New Medical Education and BioSkills Training Program 3Zimmer Launches New Medical Education and BioSkills Training Program 4
Synaptic Vesicle I Sampler Kit 10g each...
Handles samples from from 75l to 150l...
... phase reagent for Virus ... & unique water insoluble ... detergents and chaotropes; Engineered ... non-envelop viruses while preserving ...
Mouse monoclonal [N7519] to NR0B2 ( Abpromise for all tested applications). Antigen: E.coli expressed recombinant full length protein (Human) NR0B2 Entrez Gene ID: 8431 Swiss Protein ID: ...
Biology Products: