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UH researchers explore treatments for breast and colon cancers
Date:8/22/2011

he team worked with the other estrogen receptor, ERalpha, to learn more about the mechanism by which estrogen induces growth of breast cancer tumor cells. The team identified the gene KCNK5, a potassium channel regulator found in tissues that controls a wide variety of cell functions, as a key gene involved in this growth. They showed that KCNK5 was stimulated by the activation of the estrogen receptors in breast cancer cell lines and is required for tumor cell growth. With this new knowledge, the researchers confirmed the potential of KCNK5 as a target for breast cancer therapeutics.

"Building on our colon cancer research reported in the June issue, we examined the influence of estrogen on gene expression as a way of targeting and treating breast cancer tumor cells," Williams said. "The results of our research will open new opportunities for treating cancer with novel compounds, such as hormone therapy, which add, block or specifically activate only one of the two receptors in the body to combat the growth of cancer cells."


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Contact: Lisa Merkl
lkmerkl@uh.edu
713-743-8192
University of Houston
Source:Eurekalert  

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