Navigation Links
UH researchers explore treatments for breast and colon cancers
Date:8/22/2011

HOUSTON, Aug. 22, 2011 University of Houston (UH) researchers have their sights set on developing possible treatments for breast and colon cancer.

In two separate, yet related, studies published in the June and August issues of the journal Molecular Endocrinology, professor Cecilia Williams and her team at the Center for Nuclear Receptors and Cell Signaling (CNRCS) explored the role of estrogen hormones in potentially treating and preventing these cancers. More specifically, Williams examined regulatory molecules called estrogen receptors (ER), which are the tools that allow estrogen and related molecules to act in the cell.

Although estrogen is a female hormone, both men and women have receptors that are activated by estrogen. There are two types of estrogen receptors, ERalpha and ERbeta. ERalpha activity is associated with inducing breast cancer in women, whereas ERbeta is hypothesized to help prevent colon cancer.

In the first study, featured on the June cover of the journal Molecular Endocrinology, Williams and her team focused on the impact of ERbeta on colorectal cancer cells in cultures, called cell lines, to see how estrogen hormones could be used to prevent colon cancer. For each cell line, the researchers introduced this estrogen receptor to allow them to study its activity in the colon cancer cells. They found an association between the expression of ERbeta and tumor-fighting characteristics of the cells and identified the presence of several proteins involved in the protective interactions.

"Through our research, we found that the presence of estrogen receptor beta not only slowed the growth of colorectal cancer cells, but they also helped to protect against further development of the cancer," Williams said. "Our work demonstrates the potential of novel hormone compounds that activate this estrogen receptor to become possible new colon cancer preventive treatments."

In the second study, the team worked with the other estrogen receptor, ERalpha, to learn more about the mechanism by which estrogen induces growth of breast cancer tumor cells. The team identified the gene KCNK5, a potassium channel regulator found in tissues that controls a wide variety of cell functions, as a key gene involved in this growth. They showed that KCNK5 was stimulated by the activation of the estrogen receptors in breast cancer cell lines and is required for tumor cell growth. With this new knowledge, the researchers confirmed the potential of KCNK5 as a target for breast cancer therapeutics.

"Building on our colon cancer research reported in the June issue, we examined the influence of estrogen on gene expression as a way of targeting and treating breast cancer tumor cells," Williams said. "The results of our research will open new opportunities for treating cancer with novel compounds, such as hormone therapy, which add, block or specifically activate only one of the two receptors in the body to combat the growth of cancer cells."


'/>"/>

Contact: Lisa Merkl
lkmerkl@uh.edu
713-743-8192
University of Houston
Source:Eurekalert  

Related biology news :

1. Not so fast -- researchers find that lasting evolutionary change takes about 1 million years
2. Joslin researchers identify new target for treatment of type 2 diabetes and prediabetes
3. Southampton researchers awarded $28 million to progress pioneering nutrition and respiratory research
4. Researchers on the trail of a treatment for cancer of the immune system
5. SUNY Downstate researchers identify possible new targets for treating pain in women
6. Researchers investigate muscle-building effect of protein beverages for athletes
7. NYU Langone researchers reveal a new mechanism of genomic instability
8. Researchers complete first major survey of amphibian fungus in Asia
9. Researchers find new hope for treatment of chronic leukemia
10. Researchers find way to align gold nanorods on a large scale
11. UBC researchers discover key mechanism that regulates shape and growth of plants
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UH researchers explore treatments for breast and colon cancers
(Date:12/7/2016)... 2016   Veridium , a leader in ... new CEO James Stickland . Stickland, a ... experience, has served in senior executive roles for ... in expanding a pipeline of venture capital and ... recently served as managing director of U.K.-based fintech ...
(Date:12/6/2016)... -- Valencell , the leading innovator in performance ... third consecutive year of triple digit growth for its ... a 360 percent increase in companies who have acquired ... by sales of its wrist and ear Benchmark™ sensor ... for hearables for fitness and healthcare applications. ...
(Date:12/5/2016)... Dec. 5, 2016  The Office of Justice ... "Can CT Scans Enhance or Replace Medico Legal ... of supporting or replacing forensic autopsies with postmortem ... In response to recommendations made by ... using CT scans as a potential component of ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... Spain , Dec. 8, 2016  Anaconda BioMed ... the development of the next generation neuro-thrombectomy system for ... appointment of Tudor G. Jovin, MD to join its ... serve as a strategic network of scientific and clinical ... the development of the ANCD BRAIN ® to ...
(Date:12/8/2016)... ... December 08, 2016 , ... This CAST literature review and ... crops. The authors focus on the economic effects in countries that are major global ... biotech crops and the resultant risk of low level presence (LLP) puts large volumes ...
(Date:12/8/2016)... 2016 Savannah River Remediation LLC group ... NewTechBio,s NT-MAX Lake & Pond Sludge and ... in conjunction with Hexa Armor/ Rhombo cover manufactured ... Pollutant Discharge Elimination System requirements. The ... history of elevated pH levels, above 8.5, especially ...
(Date:12/7/2016)... ... December 07, 2016 , ... ACEA Biosciences, Inc. presented ... expansion clinical trial for its lead drug candidate, AC0010, at the World Conference ... was to determine the safety, antitumor activity, and recommended phase II dosage of ...
Breaking Biology Technology: