Navigation Links
UH chemist's work could impact disease management, treatments
Date:6/5/2014

HOUSTON, June 5, 2014 A University of Houston (UH) chemist hopes his work will one day impact the treatment of such diseases as cancer and malaria by better understanding how molecules react and how atoms come together to form bonds.

Jeremy May, an assistant professor of chemistry at UH, received a five-year, $600,000 National Science Foundation (NSF) CAREER Award to develop synthetic strategies to increase the efficiency and yields of chemical reactions. Often requiring a sequence of 30 to 40 different reactions, the process of complex chemical syntheses can be slow, with plenty of waste and not much yield.

"If we can develop chemical transformations that do more in each individual step, then that allows us to use a lot fewer reactions to make the end product," said May, who specializes in synthetic organic chemistry at UH's College of Natural Sciences and Mathematics. "I see similarities between my work and other increases in efficiency. In auto manufacturing, for instance, if you can do three welds at once, it's going to be faster than if you do one weld at a time on a car frame."

The grant covers the development of a reaction strategy that can form multiple molecular rings within a single transformation. This leads to more complex compounds in less time with greater yield.

"In one reaction, it goes from something that is fairly simple to something that is complex," he said. "We're working on compounds with complex interlinked structures, and we're hoping this reaction strategy will be useful to others studying these types of compounds."

In this strategy, as the number of reactions decreases, the overall yield increases. According to May, each step has a certain chemical yield, and if they can cut the number of steps or reactions in half, then it more than doubles the yield because it's like a geometric or exponential progression.

"My main interest is in chemical reactivity how do chemical bon
'/>"/>

Contact: Lisa Merkl
lkmerkl@uh.edu
713-743-8192
University of Houston
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Scripps Research Institute chemists discover structure of cancer drug candidate
2. Chemists design molecules for controlling bacterial behavior
3. Inspired by moth eyeballs, UC Irvine chemists develop gold coating that dims glare
4. Chemists work with small peptide chains may revolutionize study of enzymes and diseases
5. Notre Dame chemists discover new class of antibiotics
6. Mentoring the next generation of black chemists (video)
7. CCNY chemists use sugar-based gelators to solidify vegetable oils
8. Biochemists find incomplete protein digestion is a useful thing for some bacteria
9. CCNY chemists devise new way to prepare molecules for drug testing
10. Biochemists uphold law of physics
11. University of Wisconsin chemists find new compounds to curb staph infection
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UH chemist's work could impact disease management, treatments
(Date:8/21/2014)... Nine researchers from Beth Israel Deaconess Medical Center (BIDMC ... World,s Most Influential Scientific Minds 2014," a comprehensive ... a web resource for science metrics and research performance ... the most influential "are performing and publishing work that ... their science," according to a Thomson Reuters statement. Researchers ...
(Date:8/21/2014)... heard of the water window? It consists of radiations ... not absorbed by the water in biological tissues. New ... coherent radiations within the water window. These could be ... high-contrast image of the biological samples or to be ... identifies the physical mechanism needed to efficiently generate the ...
(Date:8/21/2014)... feeding tube connectors, designed by an international standards process, ... , According to an invited review published in the ... ( NCP ), the official journal of the American ... connectors will greatly reduce the occurrence of misconnection that ... Small-bore connectors, which are used to join medical devices, ...
Breaking Biology News(10 mins):BIDMC researchers named among 'the most influential scientific minds' 2BIDMC researchers named among 'the most influential scientific minds' 3Water window imaging opportunity 2New feeding tube connectors will improve patient safety 2
... WI, NOVEMBER 17, 2008 Global land use patterns ... urban stormwater management. Traditional stormwater management focuses on ... generally does little to restore the hydrologic cycle ... with low permeability. The lack of infiltration opportunities ...
... Mellon University,s Robotics Institute have received a total of ... Agriculture (USDA) to build automated farming systems. One is ... but both are designed to improve fruit quality and ... autonomous robotic vehicles or at fixed sites within the ...
... team of researchers led by investigators at the Albert ... that certain commonly-prescribed medications may have the unintended consequence ... finding could alter the way doctors prescribe migraine medicines. ... Headache , the Einstein-led study of more than ...
Cached Biology News:Urban trees enhance water infiltration 2Carnegie Mellon developing automated systems to enable precision farming of apples, oranges 2Carnegie Mellon developing automated systems to enable precision farming of apples, oranges 3Overuse of narcotics and barbiturates may make migraine worse 2
(Date:8/21/2014)... MO (PRWEB) August 21, 2014 ... service biopharmaceutical contract development and manufacturing organization (CMO) ... Progenics Pharmaceuticals, Inc., an oncology company focused on ... treating cancer, to manufacture the anti-prostate specific membrane ... ADC product candidate. Under the agreement the ...
(Date:8/20/2014)... 2014 Clintrax Global, Inc., a worldwide ... Raleigh, NC , recently announced the ... President of Administration. As Vice ... processes, including their alignment with company objectives and ... as an HR executive, specializing in needs assessments, ...
(Date:8/20/2014)... in measuring vibrational motion of a single molecule with ... of a single molecule differs from the behaviour of ... at the University of California, Irvine, where post-doctoral researcher ... a visiting fellow under professor Vartkess A. Apkarian, whose ... lead by Professor Eric O. Potma. The results of ...
(Date:8/20/2014)... , Aug. 20, 2014  Decision Resources Group finds that the ... Russia , India and ... in 2013, roughly equal to the size of the ... BRIC market will experience much faster growth as a result of ... Other key findings from Decision Resources Group,s coverage of ...
Breaking Biology Technology:Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 2Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 3Clintrax Global, Inc. Announces Addition to Executive Team 2Seeing a molecule breathe 2BRIC Vascular Access Device Market Valued at $1.6 Billion in 2013, Similar to the U.S. Market 2BRIC Vascular Access Device Market Valued at $1.6 Billion in 2013, Similar to the U.S. Market 3
... Va., Feb. 21, 2012 This year, approximately 7 million ... the female goes through a battery of tests, is to ... only 20% of men in couples struggling to conceive have ... Fertility ( www.spermcheck.com ), the only FDA approved at-home ...
... /PRNewswire-Asia/ -- Simcere Pharmaceutical Group (NYSE: SCR ... manufacturing, and marketing of branded generic and proprietary pharmaceuticals ... unaudited financial results for the fourth quarter and fiscal ... 2012, before the market opens in the United States. ...
... 2012 ValGenesis, Inc., a world-class provider of ... its innovative ValGenesis Suite 2.5 has achieved SAP ... platform. Attaining this certified integration status deepens ValGenesis, ... The SAP Integration and Certification Center (SAP ...
Cached Biology Technology:SpermCheck® Fertility, the Only FDA Approved At-Home Screening Test for Men to Determine Normal or Low Sperm Count, Now Available to Couples Planning or Struggling to Conceive 2Simcere Pharmaceutical Group to Announce Fourth Quarter and Fiscal Year 2011 Financial Results on Wednesday, March 7, 2012 2ValGenesis Suite 2.5 Certified by SAP as Powered by SAP NetWeaver® 2ValGenesis Suite 2.5 Certified by SAP as Powered by SAP NetWeaver® 3
...
... is essential for hunting and analyzing ... such as EST sequencing projects, microarrays, ... kit is developed for normalization of ... intended for directional cloning. While most ...
Peptide-affinity Purified Polyclonal Antibody to ICEBERG Peptide with sequence EEDPQLASKMGLH, from C Terminus of the protein sequence according to NP_067546...
Purified anti-Fanconi anemia D2-Phosphorylated (Ser222)...
Biology Products: