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UH Seidman Cancer Center researchers present at American Society of Hematology Annual Meeting
Date:12/10/2011

CLEVELAND: Researchers from Seidman Cancer Center at University Hospitals (UH) Case Medical Center and Case Western Reserve University School of Medicine presented new research findings in 25 presentations this weekend at the 53rd Annual Meeting of the American Society of Hematology (ASH) at the San Diego Convention Center.

"The breadth and depth of this innovative cancer research presented at ASH is truly outstanding," says Stan Gerson, MD, Director of the Seidman Cancer Center at UH Case Medical Center and the Case Comprehensive Cancer Center at Case Western Reserve University. "Our faculty members are making tremendous advances in hematology and oncology which is reflected in their being chosen for oral and poster presentations."

Speaking at the ASH "Scientific Symposium on Lymphoid Neoplasia" in a session titled "Autophagy and Metabolism in Lymphoid Malignancies," Clark Distelhorst, MD, provides a synthesis of the latest research indicating that autophagy occurs in lymphoid malignancies and may be a novel therapeutic target for lymphoma and other lymphoid neoplasia. His research suggests that targeting autophagy (a process through which cells eat parts of themselves to generate sufficient energy to stay alive) may be a useful adjunct to the longstanding use of glucocorticoids, such as prednisone, to kill cancer cells.

His session outlines the growing body of evidence that treatments aimed at inducing autophagy have great promise in treating lymphoid malignancies. In his session, Dr. Distelhorst presents important data explaining how glucocorticoids starve tumor cells of glucose and thus induce autophagy. Researchers at UH Case Medical Center and Case Western Reserve University identified the Dexamethasone-induced Gene 2 (dig2) that encodes a protein mediator of autophagy.

"This new cancer-fighting strategy lays the groundwork for further development of autophagy inhibitors to enhance the glucocorticoids properties,"
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Contact: Alicia Reale
alicia.reale@uhhospitals.org
216-533-0685
University Hospitals Case Medical Center
Source:Eurekalert

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