Navigation Links
UH Rainbow Babies and Children's Hospital opens asthma studies
Date:7/29/2011

CLEVELAND: Physicians at University Hospitals (UH) Rainbow Babies and Children's Hospital are participating in two new clinical trials with the national research consortium AsthmaNet. UH Rainbow, one of the 27 clinical sites in the United States, has partnered with University of Pittsburgh Medical Center (through a subcontract with Case Western Reserve University), to collaborate on these studies and future asthma clinical research studies in children and adults.

The first study will focus on new treatments for wheezing in young children who wheeze during colds, while a second will examine if Vitamin D can help adolescents and adults who cannot control their asthma through standard inhaled controller medications.

Looking for the best treatment for wheezing in preschoolers with colds

Preschool aged children often have coughing and/or wheezing leading to visits to the doctor's office, urgent care center, emergency department or even hospitalization.

This study, referred to as APRIL/OCELOT, has two parts. The purpose of the first part of the study is to determine if starting the anti-inflammatory drug azithromycin at the first signs of a cold will prevent the development of significant breathing symptoms such as frequent coughing, trouble breathing, or wheezing. If wheezing does begin, the second part of the study is focused on whether steroids are effective at reducing the severity of the wheezing and other respiratory symptoms.

"When preschool children wheeze with colds, doctors typically treat the wheezing and trouble breathing after it starts with asthma medicines," said Kristie Ross, M.D., a pediatric pulmonologist and one of the clinical researchers at UH Rainbow and an assistant professor of pediatrics at Case Western Reserve University School of Medicine. "This study is examining whether azithromycin can prevent the episodes from happening, and how best to treat wheezing when it does happen. The results from this study may give us insight into how to best treat this very common problem."

UH Rainbow hopes to enroll 30 to 40 children through UH Rainbow pediatric offices. Six hundred children will participate in the nation. The study will be a randomized, double-blind study (the "gold standard" of research studies) meaning that neither the research subjects nor the physicians will know which half of the study group is receiving one of the active treatments and which half is receiving a placebo.

Can Vitamin D help patients with asthma?

UH Rainbow also participating in the VIDA (Vitamin D add-on therapy enhances corticosteroid responsiveness in Asthma) Study. Adolescents and adults ages 18 years of age and older who have been diagnosed with asthma and are non-smokers may be eligible for the study.

The purpose of this study is to learn if taking Vitamin D in addition to an inhaled steroid -- the most effective treatment for asthma available today -- will help prevent worsening asthma symptoms and asthma exacerbations in people who have low Vitamin D levels, estimated to be up to 30 percent of the population.

"Patients who live in urban areas, especially in the northern part of the United States, such as Ohio, tend to be deficient in Vitamin D. We also see higher rates of asthma in urban centers such as Cleveland," said Dr. Ross. "Patients who have low levels of Vitamin D tend to have more severe and harder to control asthma. One reason might be that having low levels of vitamin D make it harder for inhaled steroids to work well. Although we think of vitamin D as an important vitamin for healthy bones, there is increasing evidence that it is also important in the immune system and fighting inflammation."

"Despite how common asthma is, it remains poorly understood and, in many cases, poorly treated," said James Chmiel, M.D., principal investigator for the AsthmaNet site at UH Rainbow and associate professor of pediatrics at Case Western Reserve University School of Medicine. "The possibility that improving treatment may be as easy as taking a vitamin which is activated in the skin by normal exposure to sunlight is exciting."

UH Rainbow will enroll 20 patients; 400 patients will be enrolled nationally. This study will be a double-blind randomized trial in which half patients will receive Vitamin D and the other half will receive a placebo. Neither the patients nor the doctors will know which arm of the study the patients are in.


'/>"/>

Contact: George Stamatis
george.stamatis@uhhospitals.org
216-844-3667
University Hospitals Case Medical Center
Source:Eurekalert

Related biology news :

1. Wild rainbow trout critical to health of steelhead populations
2. Rainbows without pigments offer new defense against fraud
3. World breakthrough in treating premature babies
4. Consumers desire more genetic testing, but not designer babies
5. Study finds rescue course of antenatal steroids improves outcome in premature babies
6. Mama whales teach babies where to eat
7. Engineering bouncing babies, 1 at a time
8. Tufted bacteria cause infection in premature babies
9. Babies born to native high-altitude mothers have decreased risk of low birth weight
10. ICSI or IVF: Babies born from frozen embryos do just as well
11. Supplementing babies formula with DHA boosts cognitive development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/29/2019)... ... October 29, 2019 , ... ... for biopharmaceutical R&D, today announced that Octapharma, one of the world’s largest ... support the development and manufacturing of therapeutic proteins addressing severe diseases in ...
(Date:10/26/2019)... ... October 23, 2019 , ... Medrio is pleased to announce ... leadership team. , As a market leader in solutions for EDC, Direct Data ... to reduce timelines and improve quality with real-time data capture. In her ...
(Date:10/26/2019)... N.J. (PRWEB) , ... October ... ... global provider of advanced delivery technologies, development, and manufacturing solutions for drugs, ... two presentations during the “Manufacturing and Bioprocessing Track” at the forthcoming American ...
Breaking Biology News(10 mins):
(Date:10/30/2019)... ... October 30, 2019 , ... ... showcase the many roles innovation and technology play in educating the next generation ... featured hands-on learning opportunities and presentations by WesternU administrators and representatives of companies ...
(Date:10/29/2019)... ... October 29, 2019 , ... ... skin*. Using Silios CMS-C multispectral imagers , researchers identified people by the ... identification based on retinal imaging, face recognition, fingerprints and vasculature. , The ...
(Date:10/22/2019)... SOMERSET, N.J. (PRWEB) , ... October 22, 2019 , ... ... Director, Clinical Supply Services and Drug Product Technologies Integration, will participate in a panel ... Logistics Conference (HPCLC), to be held at the Gwen Hotel, Chicago, on Oct. 28-30, ...
(Date:10/17/2019)... PARK, Kan. (PRWEB) , ... October 15, 2019 ... ... to 23andMe, a leader among services that offer DNA Testing for health and/or ... so popular. Everywhere you look, it seems that people want to know more ...
Breaking Biology Technology: