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UH Rainbow Babies and Children's Hospital opens asthma studies
Date:7/29/2011

CLEVELAND: Physicians at University Hospitals (UH) Rainbow Babies and Children's Hospital are participating in two new clinical trials with the national research consortium AsthmaNet. UH Rainbow, one of the 27 clinical sites in the United States, has partnered with University of Pittsburgh Medical Center (through a subcontract with Case Western Reserve University), to collaborate on these studies and future asthma clinical research studies in children and adults.

The first study will focus on new treatments for wheezing in young children who wheeze during colds, while a second will examine if Vitamin D can help adolescents and adults who cannot control their asthma through standard inhaled controller medications.

Looking for the best treatment for wheezing in preschoolers with colds

Preschool aged children often have coughing and/or wheezing leading to visits to the doctor's office, urgent care center, emergency department or even hospitalization.

This study, referred to as APRIL/OCELOT, has two parts. The purpose of the first part of the study is to determine if starting the anti-inflammatory drug azithromycin at the first signs of a cold will prevent the development of significant breathing symptoms such as frequent coughing, trouble breathing, or wheezing. If wheezing does begin, the second part of the study is focused on whether steroids are effective at reducing the severity of the wheezing and other respiratory symptoms.

"When preschool children wheeze with colds, doctors typically treat the wheezing and trouble breathing after it starts with asthma medicines," said Kristie Ross, M.D., a pediatric pulmonologist and one of the clinical researchers at UH Rainbow and an assistant professor of pediatrics at Case Western Reserve University School of Medicine. "This study is examining whether azithromycin can prevent the episodes from happening, and how best to treat wheezing when it does happen. The results
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Contact: George Stamatis
george.stamatis@uhhospitals.org
216-844-3667
University Hospitals Case Medical Center
Source:Eurekalert

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