Navigation Links
UGA researchers develop rapid diagnostic test for common type of pneumonia
Date:12/15/2010

Athens, Ga. University of Georgia researchers have developed a technique that can diagnose a common type of pneumonia within minutes, potentially replacing existing tests that can take several days for results.

The researchers, whose findings are detailed online in the journal PLoS ONE, detected Mycoplasma pneumoniae, which causes atypical or "walking pneumonia," in true clinical samples with over 97 percent accuracy using a recently-developed nanotechnology-based platform.

"If you can make a positive identification from a 10-minute test, then appropriate antibiotics can be prescribed, limiting both the consequences in that patient and the likelihood that it will spread to others," said lead-author Duncan Krause, a professor in the department of microbiology in the UGA Franklin College of Arts and Sciences.

Krause and his colleagues built upon an existing technology called surface-enhanced Raman spectroscopy, which works by detecting spectral signatures of a near-infrared laser as it scatters off a biological specimen. They were able to enhance the Raman signal by using silver nanorod arrays to detect the tiny bacteria in throat swab specimens.

Krause, who also directs the interdisciplinary UGA Faculty of Infectious Diseases, compared the nanorod array developed by collaborator Yiping Zhao, director of the UGA Nanoscale Science and Engineering Center, to a brush with densely packed bristles, where each of the tiny silver rods extends out at a specific angle. The sample, such as bacteria from a throat swab, penetrates among the bristles, where the spectral signature produced by the laser is amplified and then analyzed by a computer program.

Krause noted that infections due to M. pneumoniae are very common yet difficult to diagnose. The bacterium is a major cause of respiratory disease in humans and the leading cause of pneumonia in older children and young adults.

"Walking pneumonia feels like a bad chest cold that will not go away," he explained. "It can persist for weeks and even months and can cause permanent damage to the lungs if not diagnosed promptly. A delay in diagnosis extends the likelihood for complications as well as continued transmission of the infection to others."

Krause said the device can be reduced to a size that could fit in a briefcase, although their testing is currently done only in a laboratory setting. "Our hope is that when we begin to explore the capabilities of this technology, it can be applied in point-of-care testing," he added. "Then the impact becomes truly significant."

Krause hopes the combined efforts of the research specialists in nanotechnology and infectious disease will eventually be able to determine if the technique is effective in detecting other pathogens in clinical samples. "We need to do a thorough job with mycoplasmas first," said Krause. "Then we can go to other clinical samples and ask the same questions with other infectious agents."


'/>"/>

Contact: Duncan Krause
dkrause@uga.edu
706-542-2671
University of Georgia
Source:Eurekalert

Related biology news :

1. Freshwater sustainability challenges shared by Southwest and Southeast, researchers find
2. MGH researchers develop faster method of engineering zinc-finger nucleases
3. Researchers discover how natural drug fights inflammation
4. Researchers devise computer model for projecting severity of flu season
5. NIH awards $6.4 million to Case Western Reserve School of Medicine researchers
6. Researchers discover a way to delay Christmas tree needle loss
7. Researchers: Include data about societal values in endangered species decisions
8. UT Southwestern researchers uncover culprits in life-threatening clotting disorder
9. SomaLogic researchers describe revolutionary new approach to protein analysis and application to early diagnosis of lung cancer
10. Researchers describe first functioning lipidome of mouse macrophage
11. Researchers find link between sugar, diabetes and aggression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... , Mar. 23, 2017 Research and Markets ... Market Analysis & Trends - Industry Forecast to 2025" report ... ... at a CAGR of around 8.8% over the next decade to ... report analyzes the market estimates and forecasts for all the given ...
(Date:3/22/2017)... , March 21, 2017 Optimove ... used by retailers such as 1-800-Flowers and AdoreMe, ... — Product Recommendations and Replenishment. Using Optimove,s machine learning ... personalized product and replenishment recommendations to their customers ... on predictions of customer intent drawn from a ...
(Date:3/20/2017)... HANOVER, Germany , March 20, 2017 At ... Hamburg -based biometrics manufacturer DERMALOG. The Chancellor came to the ... Japan is this year,s CeBIT partner country. At the largest ... important biometrics in use: fingerprint, face and iris recognition as well as ... ...
Breaking Biology News(10 mins):
(Date:4/19/2017)... (PRWEB) , ... April 18, 2017 , ... Alisa Wright, ... Distinguished Alumni Awards from the Purdue College of Pharmacy in Lafayette, Indiana. , ... Pharmacy Program for achievements in their careers and other scientific endeavors. , Wright ...
(Date:4/19/2017)... ... April 19, 2017 , ... ThermaGenix, the PCR ... event adds to several other early achievements at ThermaGenix, including the business formation ... , ThermaGenix will use proceeds from the Series A-1 round to:, ...
(Date:4/19/2017)... PUNE, India , April 19, 2017 A ... Opportunity Analysis and Industry Forecast, 2014-2022 ," the global market was valued at ... registering a CAGR of 9.6% from 2016 to 2022. ... ...      (Logo: ...
(Date:4/19/2017)... April 19, 2017 Veracyte, Inc. ... that it will report its first quarter 2017 ... 3, 2017. Following the announcement, Veracyte,s management will host a ... Time to discuss the company,s financial results and business ... replay may be accessed by visiting Veracyte,s website at  http://investor.veracyte.com ...
Breaking Biology Technology: