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UF scientists reveal how dietary restriction cleans cells
Date:8/23/2007

GAINESVILLE, Fla. Reduce, recycle and rebuild is as important to the most basic component of the human body, the cell, as it is to the environment.

And a University of Florida study shows just how much the body benefits when it goes green, at least if youre a rat: Cutting calories helps rodents live longer by boosting cells ability to recycle damaged parts so they can maintain efficient energy production.

Caloric restriction is a way to extend life in animals. If you give them less food, the stress of this healthy habit actually makes them live longer, said Christiaan Leeuwenburgh, Ph.D., chief of the division of biology of aging in UFs Institute on Aging.

Understanding how the process works at the cellular level in rodents could help scientists develop drugs that mimic the process in humans, Leeuwenburgh added.

How does it work? During the aging process, free radicals highly reactive byproducts of our cells respiration wreak havoc on our cellular machinery. Mitochondria, the tiny power plants that keep a cell functioning, are especially vulnerable to this type of damage.

The effects can be disastrous if malfunctioning mitochondria arent removed, they begin to spew out suicidal proteins that prompt the entire cell to die. Cell death, on a whole-body scale, is what aging is all about.

Fortunately, younger cells are adept at reducing, recycling and rebuilding.

In this process, damaged mitochondria are quickly swallowed up and degraded. The broken down pieces are then recycled and used to build new mitochondria. However, older cells are less adept at this process, so damaged mitochondria tend to accumulate and contribute to aging.

Cell survival is dependent upon the ability of the cell to reduce and recycle by a mechanism called autophagy, said William Dunn Jr., Ph.D., a professor of anatomy and cell biology in UFs College of Medicine and senior author of the study, which was published
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Contact: Ann Griswold
anngriswold@gmail.com
352-273-5819
University of Florida
Source:Eurekalert

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