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UF oncologists fight leukemia with two-pronged therapy, clinical trials planned
Date:6/3/2010

portant in cancer cell survival, and that targeting them might be a good anti-cancer strategy. Karp pioneered the use of bevacizumab the antibody used in the UF studies after chemotherapy, which resulted in remission among patients with cancer that was resistant to chemotherapy or that had returned after treatment.

"The results are extremely exciting and need to be implemented clinically in a very prioritized and timely fashion," said Karp, who was not affiliated with the study.

Indeed, the U.S. Food and Drug Administration quickly gave its approval in April for a phase 1 clinical trial. That means the treatment could be available by late 2010 or the start of 2011 to eligible study volunteers at Shands at UF, as soon as the researchers are able to obtain the necessary funding for the trial.

The initial two-year trial is not designed to determine whether the drug works, but rather to determine the maximum tolerable dose. It will involve three dozen individuals age 18 and older whose cancer is growing despite previous treatment. Trial details are at the National Institutes of Health website http://clinicaltrials.gov. Search for "NCT01085656."


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Contact: Czerne M. Reid
czerne@ufl.edu
352-273-5814
University of Florida
Source:Eurekalert

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