Navigation Links
UD prof helps discover new chemical method important to drug design, agrichemicals
Date:6/24/2010

University of Delaware scientist Donald Watson is part of a research team that has discovered an easier method for incorporating fluorine into organic molecules, giving chemists an important new tool in developing materials ranging from new medicines to agricultural chemicals.

The research, which is reported in the June 25 edition of Science, was led by Stephen Buchwald, the Camille Dreyfus Professor of Chemistry at the Massachusetts Institute of Technology.

Watson worked in Buchwald's lab at MIT as a postdoctoral research associate prior to joining the UD Department of Chemistry and Biochemistry as an assistant professor this past September.

About 25 percent of pharmaceuticals contain fluorine, according to Watson, but it's difficult to incorporate the element into drug molecules. Numerous researchers have been working to develop general methods to introduce fluorine atoms into organic molecules under mild reaction conditions.

"The introduction of fluorine atoms into a pharmaceutical compound can have pronounced effects," Watson notes. "They can modulate the uptake of the drug and stabilize it against metabolism by the body, keeping it in a person's system longer and making it more effective."

The chemical method discovered by the research team uses a soluble palladium (a precious metal) catalyst to replace a chlorine atom in an aromatic molecule with a trifluoromethyl (CF3) group, which contains one carbon and three fluorine atoms. The process is highly general and occurs under mild conditions, and may become even more economical in the future as less expensive reagents are identified, Watson says.

Watson's role in the research effort was in early stage development. He dissected the complex chemical process into manageable pieces, isolating the first compounds critical to the reaction and demonstrating their effectiveness.

This is the second article in this research field that the team has pub
'/>"/>

Contact: Tracey Bryant
tbryant@udel.edu
302-831-8185
University of Delaware
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Natural chemical found in broccoli helps combat skin blistering disease
2. Device helps patients survive, regain function til transplant
3. Presence of gene mutation helps guide thyroid cancer treatment
4. CABI helps phase out dangerous pesticide in EU
5. Diet support helps chronic kidney patients
6. Argonne helps China create cleaner Beijing for 2008 Olympics
7. A tiny pinch from a z-ring helps bacteria cells divide
8. Ultraviolet light helps to secure water supply
9. MSU researcher helps develop computer game for Ugandan children recovering from cerebral malaria
10. Handbook helps parents deal with childhood infections
11. NASA technology helps predict and prevent future pandemic outbreaks
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UD prof helps discover new chemical method important to drug design, agrichemicals
(Date:8/29/2014)... German . ... cycle on Earth and in biological wastewater treatment plants. ... on nitrite as their source of energy. An international ... at the University of Vienna, has now shown that ... of energy. The oxidation of hydrogen with oxygen enables ...
(Date:8/29/2014)... release is available in German . ... signals between organisms is considered the oldest form of ... between conspecifics, for example, the sexual attraction between males ... responses and to coordinate reproductive behavior in males and ... University of the Algarve in Faro, Portugal, and at ...
(Date:8/29/2014)... species of marine phytoplankton, such as the prolific bloomer ... B1 (thiamine), researchers have discovered. The finding contradicts the ... other eukaryotic microbes depend on scarce supplies of thiamine ... different way to think about the ocean," says CIFAR ... The ISME Journal paper with CIFAR fellows ...
Breaking Biology News(10 mins):Hydrogen powers important nitrogen-transforming bacteria 2Hydrogen powers important nitrogen-transforming bacteria 3Ready for mating at the right time 2Ready for mating at the right time 3Not all phytoplankton in the ocean need to take their vitamins 2Not all phytoplankton in the ocean need to take their vitamins 3
... EuroScience Open Forum 2014 (ESOF2014) have announced some of ... science forum from 21-26 June. The Nobel Laureates ... Brian Schmidt, Australian National University, Ada Yonath, Weizmann Institute ... Biology, will be among the speakers. During EuroScience ...
... SAN FRANCISCO, January 27, 2014 -- The world,s oceans ... hasn,t happened for millions of years. But will marine ... with the waters? SF State Associate Professor of ... of scientists in calling for more studies of how ...
... For more than a century, the Hell Creek and ... captivated geologists and paleontologists alike. In Montana and adjacent ... locality for Tyrannosaurus rex and the epicenter for debate ... boundary. The 15 chapters in this volume ...
Cached Biology News:5 Nobel Laureates attending EuroScience Open Forum in Copenhagen 2New studies needed to predict how marine organisms may adapt to the future's acidic oceans 2New studies needed to predict how marine organisms may adapt to the future's acidic oceans 3
(Date:8/29/2014)... 2014 According to a new market report ... orthobiologics market was valued at USD 3,754.6 million in 2012 ... in 2019at a CAGR of 5.9% from 2013 to 2019. ... above is afflicted by bone and joint disorders, and this ... This has and will continue to increase the demand for ...
(Date:8/29/2014)... August 29, 2014 Pittcon is pleased ... and colleague Koichiro Matsuda, Horiba Scientific, have organized a ... 5, 2014. JASIS , Asia’s largest analytical and ... in Makuhari Messe, Japan. , The four speakers ... Bioanalysis from Single Molecules to Single Cells” will present ...
(Date:8/29/2014)... - iCo Therapeutics ("iCo" or "the Company") (TSX-V: ... the six months ended June 30, 2014. Amounts, ... and presented under International Financial Reporting Standards ("IFRS"). ... , Announced top-line results related to the eight ... enrolled in the Phase 2 iDEAL Study evaluating ...
(Date:8/29/2014)... (PRWEB) August 29, 2014 Local veterinarian, ... Veterinary Hospital are seeking candidates to participate in an ... osteoarthritis. The ultimate goal of this study is ... cells into one or two arthritically affected joints can ... , Candidates for the current investigational study must ...
Breaking Biology Technology:Global Orthobiologics Market to Reach $5,519.9 Million by 2019: Transparency Market Research 2Global Orthobiologics Market to Reach $5,519.9 Million by 2019: Transparency Market Research 3Fifth Annual U.S. Symposium at JASIS Organized by Pittcon’s Program Chairman Hub MacDonald 2iCo Therapeutics Announces Second Quarter 2014 Financial Results 2iCo Therapeutics Announces Second Quarter 2014 Financial Results 3iCo Therapeutics Announces Second Quarter 2014 Financial Results 4Burnt Hills Veterinary Hospital Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2
... "I am pleased to announce that Haas,TCM Inc. ... (collectively Kemfast) and its MC Technologies division have combined,with ... Haas TCM Group Inc.,ICMS Holdings, Inc. (d/b/a Avchem, Inc.), ... Haas TCM Group Inc. The focus of these,businesses is ...
... Calif., Jan. 11 Maxygen, Inc.,(Nasdaq: MAXY ... of,improved protein drugs, today announced that it will ... Conference on Thursday,January 17, 2008 at 7:45 a.m. ... present. A live webcast of the presentation can ...
... Walton, Ph.D., President, ViaGen, January 11, 2008, ... Safety Authority,s strong endorsement of the safety of food,from ... and Drug,Administration to release its final risk assessment at ... The international,scientific consensus is clear: food from these animals ...
Cached Biology Technology:The Jordan Company, L.P. Has Teamed with the Management of Haas TCM Inc. to Form Haas TCM Group Inc. 2The Jordan Company, L.P. Has Teamed with the Management of Haas TCM Inc. to Form Haas TCM Group Inc. 3Statement on the Release of the European Food Safety Assessment on the Safety of Food Derived From Clones and Their Offspring in the Food Supply 2
12 breakable polypropylene strips of 8 wells each held in a rigid frame. Ideal for antibody assays....
... Features A direct, ... molecules to the well surface ... , Maleic anhydride maintains its ... for months under dry, room ...
... a bovine protein-free alternative to StabilCoat Immunoassay ... that contains non-toxic chemicals in a PBS ... 7.2, and does not contain a preservative. ... antibodies and other biomolecules that are absorbed ...
... stabilizer is designed for stabilizing the ... antibodies for immunoassay development. It ... the coating and drying process and ... can also works as a blocking ...
Biology Products: