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UCSF transgenic mouse mimics Parkinson's earliest symptoms
Date:5/3/2010

dysfunction occurred before there was any evidence of loss of smell and also before any evidence arose of pathological changes in the brain stem.

"This suggests that, at least in mice with the human proteins, these gastrointestinal symptoms are an intrinsic defect caused by the mutant protein, rather than being caused by abnormalities in brain function," Kuo said. "That knowledge could eventually help us test for the disease long before it starts to cause neurodegenerative problems and prevent them from occurring."


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Contact: Kristen Bole
kbole@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
Source:Eurekalert

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