Navigation Links
UCSF team develops 'logic gates' to program bacteria as computers
Date:12/8/2010

A team of UCSF researchers has engineered E. coli with the key molecular circuitry that will enable genetic engineers to program cells to communicate and perform computations.

The work builds into cells the same logic gates found in electronic computers and creates a method to create circuits by "rewiring" communications between cells. This system can be harnessed to turn cells into miniature computers, according to findings that will be reported in an upcoming issue of Nature and appear today in the advanced online edition at www.nature.com.

That, in turn, will enable cells to be programmed with more intricate functions for a variety of purposes, including agriculture and the production of pharmaceuticals, materials and industrial chemicals, according to Christopher A. Voigt, PhD, a synthetic biologist and associate professor in the UCSF School of Pharmacy's Department of Pharmaceutical Chemistry who is senior author of the paper.

The most common electronic computers are digital, he explained; that is, they apply logic operations to streams of 1's and 0's to produce more complex functions, ultimately producing the software with which most people are familiar. These logic operations are the basis for cellular computation, as well.

"We think of electronic currents as doing computation, but any substrate can act like a computer, including gears, pipes of water, and cells," Voigt said. "Here, we've taken a colony of bacteria that are receiving two chemical signals from their neighbors, and have created the same logic gates that form the basis of silicon computing."

Applying this to biology will enable researchers to move beyond trying to understand how the myriad parts of cells work at the molecular level, to actually use those cells to perform targeted functions, according to Mary Anne Koda-Kimble, dean of the UCSF School of Pharmacy.

"This field will be transformative in how we harness biology for bi
'/>"/>

Contact: Kristen Bole
kristen.bole@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Iowa State, Ames Lab researcher develops new way to study single biological molecules
2. MU scientist develops salmonella test that makes food safer, reduce recalls
3. IVCC develops new public health insecticides
4. NC State develops more precise genetic off switches
5. Yale develops new animal model for hemophilia A
6. Research develops simple recipe for fungus-free horseradish
7. CCNY-led team develops non-toxic oil recovery agent
8. Harvards Wyss Institute develops technology to produce sugar from photosynthetic bacteria
9. ISU researcher develops green, bio-based process for producing fuel additive
10. Military develops multi-purpose green decontaminants for terrorist attack sites
11. CSIRO develops highest-yielding salt-tolerant wheat
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UCSF team develops 'logic gates' to program bacteria as computers
(Date:7/25/2014)... an unknown interaction between microorganisms and salt. When ... of salt water and is left to dry, bacteria ... 3D morphologically complex formations, where they hibernate. Afterwards, simply ... was made by chance with a home microscope, but ... journal and may help to find signs of life ...
(Date:7/24/2014)... 24, 2014 /PRNewswire-iReach/ -- The Geneva Healthcare Suite, an ... has cut emergency room wait times by an average ... Medical Center, according to a recent study published in ... are using the suite to access data from incoming ... "Using Geneva,s technology platform we have been ...
(Date:7/24/2014)... that characterize sustainable university and college programs designed ... teachers. Specifically, one or more faculty members who ... with institutional motivation and commitment can ensure that ... Math (STEM) teacher shortages are especially acute in ... institutions seeking to increase the number of STEM ...
Breaking Biology News(10 mins):Bacteria manipulate salt to build shelters to hibernate 2UC San Diego Medical Center Cuts Average ER Wait Time by 92 Minutes using the Geneva Healthcare Suite 2UC San Diego Medical Center Cuts Average ER Wait Time by 92 Minutes using the Geneva Healthcare Suite 3Creating sustainable STEM teacher preparation programs 2
... to humane alternatives to the use of animals in research ... requires using animals as part of the testing, what do ... Responsible Medicine, you invent your own test. , PCRM president ... world's first cruelty-free insulin assay, a test used to measure ...
... devices intended to optimize the cardiac function of patients ... patients might be at higher risk of dying suddenly ... Medical Center. , Besides maintaining optimal electrical stimulation to ... devices are giving cardiologists a new view of subtle ...
... It seems survival of the fittest affect every organism ... resistant than non-migratory ones to parasite infections; scientists just ... quite don't make it while migrating long distances, so ... , A little-studied outcome of animal migration is ...
Cached Biology News:PCRM develops world's first cruelty-free insulin assay 2Implanted Devices Detect High-Risk Heart Failure Patients 2Implanted Devices Detect High-Risk Heart Failure Patients 3
(Date:7/26/2014)... July 26, 2014 Canada Endoscopy ... market data on the Canada Endoscopy Visualization Systems ... US dollars, volume (in units) and average prices ... Endoscopy Visualization Systems, Mid-Range Endoscopy Visualization Systems and ... at http://www.marketresearchreports.biz/analysis/213254 . , The report also ...
(Date:7/25/2014)... 2014 "Ischemic Stroke and Cerebral ... data on the Ischemic Stroke and Cerebral Stroke ... and data relating to the clinical trials on ... global Ischemic Stroke Research Report 2014 at: ... the trial numbers and their recruitment status as ...
(Date:7/25/2014)... , July 25, 2014 Amgen (NASDAQ: ... today declared a $0.61 per share dividend for the ... on Sept. 5, 2014, to all stockholders of record ... 2014.  About Amgen Amgen is committed ... from serious illnesses by discovering, developing, manufacturing and delivering ...
(Date:7/25/2014)... MA -- Trillions of bacteria live in each person,s ... help digest food and stave off harmful infections, but ... , To help shed light on the role of ... associate professor Eric Alm recently tracked fluctuations in the ... year. The findings, described in the July 25 issue ...
Breaking Biology Technology:Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 2Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 3Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 4Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 5Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 2Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 3Amgen Announces 2014 Third Quarter Dividend 2Amgen Announces 2014 Third Quarter Dividend 3Monitoring the rise and fall of the microbiome 2Monitoring the rise and fall of the microbiome 3
... AquaSensors , a Milwaukee-area company that makes ... a $360,000 investment from local angel group Silicon Pastures. ... which various sensors for water, waste-water, food, beverages, chemicals, ... to a standard "stick" device that converts the signals ...
... Before the calendar turns to a new year, here ... in 2005. Take it easy on the professor if ... ,Innovation: A minus. Wisconsin continues to produce more than ... such as the Wisconsin Alumni Research Foundation (WARF) and ...
... and financing of health care in the United States are ... , About one in seven Americans (15.7 percent) lack health ... According to the latest federal figures, health spending accounts for ... $1.68 trillion in 2003 works out to $5,670 for each ...
Cached Biology Technology:Grading Wisconsins high-growth economy 2Grading Wisconsins high-growth economy 3Health care economics make definition of 'cost' problems difficult 2Health care economics make definition of 'cost' problems difficult 3
KNP-1 (HES1) Purified Anti-Mouse, Anti-Rat, Anti-Human, Anti-Dog, Anti-Chicken clone 35, Isotype Mouse IgG 1 , 150 µg Consult technical datasheet for details....
Request Info...
Form: Ready to use Applications: Immunohistology-frozen, Immunohistology-paraffin, Western Blot, ELISA...
... H): 17 3/4" x 8 ... Programmable 0 - 100 hoursControl: Programmable 30 ... 40 user programmable protocols 3 operating modes ... temperature ramp-up from 37 - 95C and ...
Biology Products: