Navigation Links
UCSF researchers identify new drug target for Kaposi's sarcoma
Date:7/30/2009

UCSF researchers have identified a new potential drug target for the herpes virus that causes Kaposi's sarcoma, re-opening the possibility of using the class of drugs called protease inhibitors against the full herpes family of viruses, which for 20 years has been deemed too difficult to attain.

The new drug target, which is known as a protease dimer, could serve as a model for developing new therapeutics for diseases ranging from cancer to Alzheimer's, the researchers say. Findings are reported in the Advance Online Publication section of the "Nature Chemical Biology" web site and can be found at www.nature.com/nchembio/index.html.

Most current antiviral drugs target the active sites of viral proteins, where enzymes and receptors work in a lock-and-key approach to either activate or deactivate that particular protein, the researchers explained. Traditionally, drug development has focused on inhibiting that lock-and-key action to prevent the enzyme, or receptor from being effective.

Some viral enzymes known as proteases, however, including those for HIV and the herpes virus family, take the form of a dimer, or two identical halves much like a fully opened clamshell in their most stable state. Those proteases play an essential role in making the virus infectious, but require the two clamshell halves to bind together to be activated, according to the paper.

The HIV protease was successfully targeted for drug development in the 1980s, by blocking the active site on the surface of the dimer, but the herpes virus protease dimer has consistently eluded efforts to disrupt it at its active site, the researchers said.

The UCSF team set out to find ways to instead prevent the two halves of the dimer from connecting at that clamshell joint, to prevent it from activating. What they found was a new target on the unstable, monomer form of the protease, which respond
'/>"/>

Contact: Kristen Bole
kbole@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Fox Chase researchers uncover one force behind the MYC oncogene in many cancers
2. 1 in 6 health workers wont report in flu pandemic -- study by Ben-Gurion U. researchers
3. Researchers team up to provide new hope for childhood hunger
4. UBC researchers help push for standard DNA barcodes for plants
5. Researchers develop brain-reading methods
6. ISU researchers find possible treatment for spinal muscular atrophy
7. Researchers capture bacterial infection on film
8. Researchers design first model motor nerve system thats insulated and organized like the human body
9. Iowa State University researchers develop process for surgical genetic changes
10. UCLA researchers discover new molecular pathway for targeting cancer, disease
11. Munich researchers discover new target for tailored antibiotics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... Rice University researchers are using magnetic beads and ... can be used as microscale models for polymer macromolecules. ... introduced as theory in the 1950s, can be made ... be of interest to materials scientists who study the ... Rice chemical and biomolecular engineer Sibani Lisa Biswal and ...
(Date:7/28/2014)... killers to prevent and treat HIV infection has been ... these molecules can arouse as they get rid of ... the Weizmann Institute and the National Institutes of Health ... molecules interferons around the time of infection ... disease. Their research appeared in Nature . ...
(Date:7/28/2014)... explorer Roald Amundsen became the first man to reach ... 100 years later, an international team of scientists led ... have proven that air pollution from industrial activities arrived ... collected from widely spaced locations around the Antarctic continent, ... accurate and precise reconstruction to date of lead pollution ...
Breaking Biology News(10 mins):Seeing is bead-lieving 2Interfering with interferon 2Industrial lead pollution beat explorers to the South Pole by 22 years and persists today 2Industrial lead pollution beat explorers to the South Pole by 22 years and persists today 3
... are losing about 1.6 million tonnes of carbon per year ... economy and carbon accounts, according to new research.,Top soil is ... away by events such as the ,Red Dawn, in Sydney ... the atmosphere it changes the amount and location of soil ...
... Improved diagnosis for people afflicted with carpal tunnel syndrome ... is the goal of a research collaboration led by an ... Clinic physician. Marco Santello and Mark Ross were recently ... Medicine to advance their effort to quantify the effects of ...
... help determine the vulnerability of public-supply wells to contamination. ... into which contaminants in an aquifer might reach a ... might arrive. About one-third of the U.S. population ... the understanding of the vulnerability of public-supply wells to ...
Cached Biology News:Soil carbon 'blowing in the wind' 2ASU-Mayo research project targets carpal tunnel syndrome diagnosis 2New insight on vulnerability of public-supply wells to contamination 2
(Date:7/28/2014)... MD (PRWEB) July 28, 2014 ... personalized medicine, will be exhibiting data and research conducted ... International Spine Intervention Society’s (ISIS) 22nd Annual ... 3rd, at the Hyatt Regency, in Orlando, Florida. ... knowledge and clinical competence of physicians who care for ...
(Date:7/28/2014)... DALLAS , July 28, 2014 /PRNewswire/ ... research report  "Microbial Identification Market by Products (Consumables, Instruments, ... & Beverages), End User (Detection, Characterization) - ... global Microbial Identification Market is estimated at ... to reach $1,194.1 Million by 2019, growing ...
(Date:7/28/2014)... --  Propeller Health , the FDA-cleared digital health solution ... Brad Towle as Senior Vice President, Business and ... company,s sales growth, customer acquisition and program expansion. ... past role in the development of accountable care organizations, ... time in the industry," said David Van Sickle ...
(Date:7/28/2014)... 28, 2014 The global market for ... 2020, according to a new study by Grand View ... demand for effective vaccines and drugs in an attempt ... needs is expected to drive market demand over the ... agricultural productivity via the use of genetically engineered seeds ...
Breaking Biology Technology:Proove Biosciences Exhibits Industry Leading Data and Research at International Spine Intervention Society’s 22nd Annual Scientific Meeting 2Microbial Identification Market worth $1,194.1 Million by 2019 2Microbial Identification Market worth $1,194.1 Million by 2019 3Propeller Health Hires Brad Towle as Senior Vice President of Business and Client Development 2Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 2Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 3Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 4
... 12 VIA Pharmaceuticals,Inc. (Nasdaq: VIAP ), a ... treatment of cardiovascular disease, announced today that,James G. Stewart, ... present a company update at the Fourth Annual Noble ... 19, 2008 at the Loews Lake,Las Vegas Resort in ...
... and Webcast on Monday, August 18, 2008, ... Beginning at 1:00 PM Eastern Time, LIVINGSTON, ... recognized leader in,advanced injection technologies, today announced that it plans to ... 2008 on the morning,of Thursday, August 14, 2008., Milestone Scientific ...
... DSM Biologics and MorphoSys,AG (Frankfurt Stock Exchange: ... signing of a Biopharmaceutical Manufacturing Agreement,covering process ... is a,fully human HuCAL(R) antibody, directed against ... multiple myeloma. DSM Biologics will manufacture,MOR202 in ...
Cached Biology Technology:VIA Pharmaceuticals to Present at Fourth Annual Noble Financial Equity Conference 2Milestone to Report Results for 2008 Second Quarter on Thursday, August 14, 2008 2DSM Biologics and MorphoSys AG to Manufacture Fully Human Antibody 2DSM Biologics and MorphoSys AG to Manufacture Fully Human Antibody 3
Modified and insect cell culture tested....
Bethyl Laboratories Epitope Retrieval Buffer-Reduced pH will unmask antigenic sites from formaldehyde fixation and allow for subsequent immunostaining. Shelf-Life: 1 year from date of receipt...
Mycoplasma and virus tested...
Edited by Benjamin Lewin (1997) • This book gives an integrated account of the structure and function of genes in both prokaryotic organisms and is thoroughly up to date with the latest thinking...
Biology Products: