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UCSF researchers identify 2 key pathways in adaptive response
Date:8/21/2009

nite set of core structures can execute a particular function.

"From a scientific standpoint, this is about one thing: Are there universal principles in biology, and if so, what are they," Tang said.

The potential applications from these studies could be tremendous: in medicine, an understanding of what causes a system to shift from one behavior to another could greatly aid in developing more targeted therapeutics for treatments of complex diseases like cancer, the researchers said.

Fundamentally, the complex network of homeostatic response is what makes these diseases so difficult to tackle therapeutically, according to the research team. If the entire network is out of balance, a drug that blocks a single receptor won't work. Identifying the core structures behind adaptive response, however, makes it possible to someday create a therapy that could readjust that network.

It also could have applications in the emerging field of synthetic biology, by serving as a manual for how to engineer robust biological circuits that carry out a target function.


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Contact: Kristen Bole
kristen.bole@ucsf.edu
415-476-2557
University of California - San Francisco
Source:Eurekalert

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