Navigation Links
UCSF researchers identify 2 key pathways in adaptive response
Date:8/21/2009

UCSF researchers have identified the two key circuits that control a cell's ability to adapt to changes in its environment, a finding that could have applications ranging from diabetes and autoimmune research to targeted drug development for complex diseases.

The new findings are featured as the cover story in the August 21, 2009 issue of the journal "Cell" and are available online at http://www.cell.com.

The limited number of circuits that can achieve adaptation represents a fundamental shift in our understanding of this important biological behavior, which previously had been thought to be affected by hundreds of different circuits, according to Chao Tang, PhD, who was co-senior author on the paper with Wendell Lim, PhD.

Both Lim and Tang are faculty members in the UCSF departments of Bioengineering and Therapeutic Sciences and of Biochemistry and Biophysics, and are affiliated with the California Institute for Quantitative Biosciences (QB3) at UCSF.

Adaptation is a fundamental property of many cellular sensing systems, allowing the cell to automatically reset itself after responding to a stimulus, Lim said. These adaptive circuits are what enable eyes to adjust to changes in light, white blood cells to move toward bacteria, or insulin levels to adjust to sugar loads. They are involved in heat adaptation, movement, sight and smell, among others. They also are often the mechanisms that go wrong at a molecular level in some of the most difficult diseases to treat.

"Many diseases are diseases of homeostasis," explained Lim, who is also affiliated with the Howard Hughes Medical Institute. "Diabetes or autoimmune diseases, for example, are based on a disruption in the circuitry that prevents the body from readjusting itself."

Until now, however, the millions of circuits involved in that adaptive response were impenetrably complex.

For this research, the team us
'/>"/>

Contact: Kristen Bole
kristen.bole@ucsf.edu
415-476-2557
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Disrupting a destructive duo: U of T Mississauga researchers inhibit cancer proteins
2. Researchers boost production of biofuel that could replace gasoline
3. Researchers find genetic link between physical pain and social rejection
4. UTSA biology researchers demystify elusive war zone bacterium
5. UGA researchers propose model for disorders caused by improper transmission of chromosomes
6. Researchers develop new, more-sensitive assay for detecting DNA methylation in colon cancer
7. NIH-funded researchers sequence exomes of 12 people
8. USC researchers identify regulatory genetic sequences that may predict risk for prostate cancer
9. K-State lab gives researchers the tools to study porcine circovirus associated diseases
10. Hebrew U. researchers shed light on the brain mechanism responsible for processing of speech
11. SLAC researchers reveal the dance of water
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2014)... analyzed concentrations of African dust transported to South ... spring. These research findings offer new insight on ... of African dust, including the climate change-induced human ... increased African dust emissions in the coming decades., ... School of Marine and Atmospheric Science and colleagues ...
(Date:8/19/2014)... release is available in German . ... new information about the metabolism of plants can switch ... Erich Kombrink from the Max Planck Institute for Plant ... University of Duisburg-Essen adopt a different approach. They identify ... process like brake pads and prevent the downstream reactions. ...
(Date:8/19/2014)... DIEGO, Calif. (August 19, 2014) Daylight was breaking ... MY Hanse Explorer. Between sips, about a dozen scientists ... and slip below the surface to collect water samples ... would tinker with the whirring gizmos and delicate machinery ... single goal: Be the first research group to bring ...
Breaking Biology News(10 mins):Study of African dust transport to South America reveals air quality impacts 2Researchers block plant hormone 2Researchers block plant hormone 3Sequencing at sea 2Sequencing at sea 3
... WORCESTER, Mass. A Worcester Polytechnic Institute (WPI) research ... the National Institutes of Health (NIH) to continue a ... to tools that will enable physicians to predict the ... heart attacks and strokes. Led by Dalin Tang, PhD, ...
... of bacteria can produce a lethal chemical that keeps ... the growth of nearby colonies and even killing some ... for themselves, even when the encroaching colony is closely ... is a superorganism, a multicellular organism with it,s own ...
... German . , In the coming decades, ... living conditions for plants, whereby major regional differences may be ... future provide habitats for additional species, and in arid and ... plant diversity will deteriorate. This is the conclusion reached in ...
Cached Biology News:WPI receives $1.4 million from NIH for pioneering work on arterial plaque and cardiovascular disease 2WPI receives $1.4 million from NIH for pioneering work on arterial plaque and cardiovascular disease 3Colonies of bacteria fight for resources with lethal protein 2Global warming threatens plant diversity 2Global warming threatens plant diversity 3
(Date:8/19/2014)... , Aug. 19, 2014 /PRNewswire/ - iCo Therapeutics Inc. ... today reported results of its Oral Amphotericin B ... reservoirs.  The study, conducted by ImmuneCarta®, the immune ... vitro effectiveness of Oral Amp B in ... in individuals despite intensive treatment with antiretroviral therapy. ...
(Date:8/18/2014)... FREDERICK, Md. , Aug. 18, 2014 ... the maker of advanced consumer medical devices ... Kotak was interviewed by CEOLIVE.TV as ... The entire interview is available at ... interview Dr. Kotak explains to investors the ...
(Date:8/18/2014)... According to the new ... (Municipal Wastewater Treatment and Industrial Wastewater Treatment), By ... By Configuration (Internal/Submerged and External/Sidestream), and By Region-Trends ... market for membrane bioreactor systems is projected to ... CAGR of 15.28% between 2014 and 2019. ...
(Date:8/16/2014)... NY (PRWEB) August 16, 2014 ... industry provide guidance and advisory services to ... and technical issues. Industry services are highly diverse ... Therefore, industry services range from geological and geophysical ... plans. “Consequently, over the past five years, the ...
Breaking Biology Technology:iCo Therapeutics Announces Positive Oral Amphotericin B Study Results 2iCo Therapeutics Announces Positive Oral Amphotericin B Study Results 3BioElectronics EVP Dr. Deepak Kotak Interviewed on CEO Live 2BioElectronics EVP Dr. Deepak Kotak Interviewed on CEO Live 3Membrane Bioreactor Systems Market Worth $2,927 Million by 2019 2Membrane Bioreactor Systems Market Worth $2,927 Million by 2019 3Scientific and Economic Consulting in Canada Industry Market Research Report Now Available from IBISWorld 2Scientific and Economic Consulting in Canada Industry Market Research Report Now Available from IBISWorld 3
... CPHD ) today announced that it will report financial results ... 30, 2009, after the close of the market. , , ... Time on Thursday, July 30, 2009, to discuss the results. ... www.cepheid.com/investors at least 15 minutes before the scheduled ...
... June 25, 2009 Veritide Ltd., a developer of ... new independent data to be presented at the Biodetection ... Ceeker (pronounced "seeker") portable bacterial detection device in discriminating ... data show that in over two weeks of testing ...
... N.J. Dr. Frank Fisher, an Assistant Professor of ... and Co-Director of the Graduate Nantoechnology Program at Stevens ... two 2009 Ferdinand P. Beer and E. Russell Johnston ... of Engineering Education (ASEE). , Fisher was selected on ...
Cached Biology Technology:Cepheid Schedules 2009 Second Quarter Financial Results Announcement and Webcast 2Novel handheld device detects anthrax with outstanding accuracy and reliability 2Novel handheld device detects anthrax with outstanding accuracy and reliability 3
...
... measures NOS activity by monitoring the conversion ... is simple, sensitive, and specific for NOS ... crude and purified enzyme preparations. The kit ... total reactions. Radiolabeled arginine and NADPH are ...
Human TSLP MAb (Clone 258136)...
Human Complement Component C5a MAb (Clone 295003)...
Biology Products: