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UCSF receives $15 million to advance personalized medicine
Date:9/7/2010

e anti-diabetic drug metformin in African American patients with type 2 diabetes.

The field of membrane transporter pharmacogenomics has undergone enormous growth over the last decade, Giacomini said, and it is expected to have a significant impact on our understanding of pharmaceutical therapies over the next decade as well. In fact, the field of pharmacogenomics is expected to see enormous change, she said.

"Thanks to breakthroughs in genome sequencing technologies and our growing understanding of genetic variation among individuals, there has never been a better time to propel the field of pharmacogenomics," said NIH Director Francis S. Collins, MD, PhD. "Through these studies, we are moving closer to the goal of using genetic information to help prescribe the safest, most effective medicine for each patient."

Giacomini also will oversee a $3.2 million grant under the NIH program, to continue and expand a Global Alliance for Pharmacogenomics. This alliance involves NIH funded scientists in the Pharmacogenomics Research Network and scientists from the Center for Genomic Medicine, Riken, Yokohama, Japan.

The alliance will focus on large genomic studies of drug response from many drug classes, including those targeting cancer, asthma, cardiovascular disease and diabetes. The goal of the alliance is to identify genetic markers that determine both therapeutic and adverse drug responses in multiple racial and ethnic populations. These markers can eventually be used to guide drug therapy.

"This research requires analysis of vast amounts of data that can only be tackled through collaborative efforts among scientists and clinicians in many institutions," Giacomini said. "The global alliance will enable us to bring together the best and brightest in this field, from around Japan and the U.S., to achieve the goals of personalized medicines."

The new awards include 14 scientific research projects and seven network resou
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Contact: Kristen Bole
kristen.bole@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert

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