Navigation Links
UCSF discovers new glucose-regulating protein linked with diabetes
Date:5/28/2009

Researchers at the University of California, San Francisco, and collaborators at Harvard Medical School have linked a specialized protein in human muscles to the process that clears glucose out of the bloodstream, shedding light on what goes wrong in type 2 diabetes on a cellular level.

Establishing the function of this protein, which significantly is not present in mice, has broad implications for both the future study and possible therapies for diabetes, according to an article published in the May 29, 2009 issue of the journal "Science."

While a significant amount of research into diabetes and many other diseases is conducted in mice, the often-unknown differences between mice and men can create obstacles to direct translation of such research and need to be taken into account in understanding the progression of human disease, according to the researchers.

"Much has been learned from mouse models about glucose metabolism that is relevant to human diabetes, but what happens on a cellular level is now found to be different between the two species," said Frances Brodsky, DPhil, senior author on the paper and a UCSF professor in the Departments of Bioengineering and Therapeutic Sciences, Pharmaceutical Chemistry, and Microbiology and Immunology. "This research shows one significant species-specific difference that will influence our understanding of mechanisms of type 2 diabetes."

In humans, muscles play a key role in clearing glucose from the bloodstream, Brodsky explained. In normal function, this is controlled by insulin, which stimulates the muscle cells to import glucose by means of a system known as the GLUT4 glucose transporter.

Normally, she said, GLUT4 is stored inside both human and mouse muscles in a special compartment that releases it upon insulin stimulation. Fat cells also form a GLUT4 compartment and take up glucose in response to insulin. In type 2 diabetes, however, the muscle and fat cel
'/>"/>

Contact: Kristen Bole
kbole@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
Source:Eurekalert

Page: 1 2

Related biology news :

1. deCODE discovers cause of major subtype of glaucoma
2. CU-Boulder team discovers first ancient manioc fields in Americas
3. Weill Cornell team discovers how brains own tPA helps regulate blood flow to neurons
4. QUT researcher discovers Maya mask splendor
5. CSHL scientists part of team that discovers role of rare gene mutations in schizophrenia
6. Researcher discovers pathway plants use to fight back against pathogens
7. NYU dental professor discovers biological clock linking tooth growth to other metabolic processes
8. U of T discovers environmental factors linked to sex ratio of plants
9. N.Y. research team discovers how antidepressants and cocaine interact with brain cell targets
10. Wildlife Conservation Society discovers Planet of the Apes
11. UCR graduate student discovers, names bacterium linked to psyllid yellows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2014)... survived the asteroid strike that wiped them out if ... history, scientists say. , A fresh study using up-to-date ... to build a new narrative of the prehistoric creatures, ... that in the few million years before a 10km-wide ... environmental upheaval. This included extensive volcanic activity, changing sea ...
(Date:7/27/2014)... climate change to cut food supplies. But these studies ... increasing temperature and air pollution specifically ozone pollution, ... study involving researchers at MIT shows that these interactions ... take both warming and air pollution into account in ... at global production of four leading food crops ...
(Date:7/25/2014)... the first broad-scale estimate of air pollution removal by ... that trees are saving more than 850 human lives ... symptoms. , While trees, pollution removal equated to an ... the impacts of that improvement are substantial. Researchers valued ... at nearly $7 billion every year in a study ...
Breaking Biology News(10 mins):Dinosaurs fell victim to perfect storm of events, study shows 2Study: Climate change and air pollution will combine to curb food supplies 2Study: Climate change and air pollution will combine to curb food supplies 3First national study finds trees saving lives, reducing respiratory problems 2
... first large, single-institution series directly comparing weight-loss outcomes ... Chicago found that a newer operation, the duodenal ... standard operation, the Roux-en-Y gastric bypass. , In ... the researchers report that the duodenal switch (DS) ...
... recent years, health professionals and the general public alike have ... from a flu pandemic. Although many people might still recall ... 1918-1920 pandemic--and the possibility of a recurrence on that scale--that ... still don't know exactly how many people died from this ...
... amount of MDMA, better known as ecstasy, can be harmful ... at the neurotoxic effects of low doses of the recreational ... at the annual meeting of the Radiological Society of North ... in some areas of the brain in young adults who ...
Cached Biology News:For super-obese patients, duodenal switch beats gastric bypass 2For super-obese patients, duodenal switch beats gastric bypass 3Recurrence of a flu pandemic similar to infamous 1918 flu could kill 62 million 2Recurrence of a flu pandemic similar to infamous 1918 flu could kill 62 million 3Ecstasy can harm the brains of first-time users 2
(Date:7/28/2014)... July 28, 2014  David Hardison, Ph.D., vice ... Deloitte , has been elected chairman of the ... a non-profit working to establish common protocols around ... it relates to electronic health records. ... of collaborating with organizations across the research and ...
(Date:7/28/2014)... July 28, 2014 The global market ... by 2020, according to a new study by Grand ... rising demand for effective vaccines and drugs in an ... medical needs is expected to drive market demand over ... enhance agricultural productivity via the use of genetically engineered ...
(Date:7/26/2014)... Canada Endoscopy Visualization Systems Market ... the Canada Endoscopy Visualization Systems market. The report ... (in units) and average prices (in US dollars) ... Mid-Range Endoscopy Visualization Systems and Low-End Endoscopy Visualization ... . , The report also provides company shares ...
(Date:7/25/2014)... , July 25, 2014 Research ... "Global Metabolomics Market 2014-2018" report to ... Metabolomics or Metabonomics is the ... has become a new experimental technique that is ... environmental sciences. Metabolites are small molecules that are ...
Breaking Biology Technology:ConvergeHEALTH by Deloitte's David Hardison Named Chairman of the Clinical Data Interchange Standards Consortium 2ConvergeHEALTH by Deloitte's David Hardison Named Chairman of the Clinical Data Interchange Standards Consortium 3Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 2Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 3Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 4Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 2Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 3Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 4Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 5Global Metabolomics Market 2014-2018: Key Vendors are Agilent, Bio-Rad, Bruker, Human Metabolome and Metabolon 2
... Imaging Diagnostic,Systems, Inc., (OTC Bulletin Board: IMDS), a ... recent study on CTLM is one of the featured,scientific ... Dr. Jin Qi,a radiologist at the Tianjin Medical ... her paper, "CTLM as an Adjunct to Mammography,in the ...
... strong pipeline makes the,Copenhagen Region biotech cluster well prepared for ... development, Denmark,ranks third in Europe. Only United Kingdom and Germany ... Also in term of pipeline growth Denmark has a ... countries in Europe. , ...
... 1 Collexis Holdings, Inc.,(OTC Bulletin Board: ... and,knowledge discovery software, announced today a partnership ... promote BiomedExperts.com,to the association,s 200+ membership base. ... primary professional network for,BioFlorida, helping to facilitate ...
Cached Biology Technology:Imaging Diagnostic Systems CT Laser Mammography (CTLM(R)) System Featured at the 94th Annual Radiological Society of North America (RSNA) Conference 2Imaging Diagnostic Systems CT Laser Mammography (CTLM(R)) System Featured at the 94th Annual Radiological Society of North America (RSNA) Conference 3Ernst & Young Benchmarks Danish Biotech Pipeline Third in Europe 2BioFlorida Selects Collexis' BiomedExperts.com as the Primary Professional Network for its 200 Member Companies and Organizations 2BioFlorida Selects Collexis' BiomedExperts.com as the Primary Professional Network for its 200 Member Companies and Organizations 3BioFlorida Selects Collexis' BiomedExperts.com as the Primary Professional Network for its 200 Member Companies and Organizations 4
... Gel-Digesting Preparation contains a unique β-agarose digesting ... recovery of intact DNA and RNA from ... electrophoresis in TAE, TBE, MOPS, or phosphate ... in the TAE, TBE, MOPS, and phosphate ...
... in-house demand is causing shortages in your laboratory ... can cause unwanted distractions, problems and delays. ... hard work and endeavour! Bring us your idea ... it internationally. We work under ISO 9001 quality ...
... causing shortages in your laboratory or fellow researchers ... distractions, problems and delays. • ... endeavour! Bring us your idea and let us ... work under ISO 9001 quality assurance in design, ...
Topoisomerase I...
Biology Products: