Navigation Links
UCSF biochemist wins prestigious prize
Date:12/23/2011

olled, however, to ensure that the body does not poison itself by releasing toxic proteins that are not processed correctly. The unfolded protein response is one of the main ways cells maintain this control.

Basically, explained Walter, "The unfolded protein response makes life and death decisions for the cell."

Those decisions happen in an involuted compartment found within cells known as the endoplasmic reticulum (ER), which can be thought of as a cell's warehouse and way station rolled into one. The vast majority of all the proteins a cell produces are assembled, processed, and packaged there, and the ER ensures that proteins are folded correctly into their final shape and that no misfolded, and potentially malfunctioning and toxic, proteins are released into surrounding tissues.

The ER warehouse can become overworked and too crowded at times, putting stress on cells. When stressed, cells can exercise a sort of nuclear option, switching on a program known as apoptosis and killing themselves. The unfolded protein response is a fail-safe switch in this mechanism. It can pull a cell back from the edge by making more ER, expanding capacity for more proteins to fold properly, thereby relieving the stress.

A few years ago Walter discovered the lynchpin in the process, a protein known as IRE1. This protein is a molecular detector in the ER that gauges when things become too crowded and triggers cell changesthat expand ER space.

This process can also go awry, and when it does, it can lead to a number of different diseases, including cancer. In multiple myeloma, for instance, IRE1 appears to go haywire and the cancer cells "forget how to die," as Walter described it.

Blocking the IRE1 protein with small molecules may help people with this form of cancer, he saida therapeutic possibility that Walter and his colleagues are actively pursuing.

"The Paul Ehrlich and Ludwig Darmstaedter Prize is particularly specia
'/>"/>

Contact: Jason Socrates Bardi
jason.bardi@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. UC Riverside biochemists devise method for bypassing aluminum toxicity effects in plants
2. Vitamin D a key player in overall health of several body organs, says UC Riverside biochemist
3. Biochemistry of human physiology in health and disease is focus of updated clinical text
4. Phytoplankton cell membranes challenge fundamentals of biochemistry
5. UC Riverside biochemist to study how crops can increase protein production
6. ASBMB Annual Meeting to feature talks on the biochemistry of aging
7. Springer partners with the American Society for Biochemistry and Molecular Biology
8. Stimulus funding helps K-State biochemist study eyes lens in diabetes, galactosemia patients
9. Biochemist researching computer models of protein structure that help high school, college students
10. Biochemist unlocks genes role in breast-tumor growth
11. Colorado State University biochemists study how chromosomes unravel to let genes do their jobs
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UCSF biochemist wins prestigious prize
(Date:7/10/2014)... 2014  Pomerantz LLP has filed a class ... the "Company")(NYSE-MKT: PVCT) and certain of its officers.  ... Court, Middle District of Tennessee ... class consisting of all persons or entities who ... 17, 2013 and May 22, 2014, both dates ...
(Date:7/10/2014)... 1, 2014 Smart technology emphasis grows ... and improved security: NXT-ID, Inc. (OTCBB: NXTD), eBay Inc. (NASDAQ: ... ), Apple Inc. (NASDAQ: AAPL ), Visa Inc. ... NXT-ID, Inc., (OTCQB: NXTD) a biometric authentication company focused ... the second series of 30 second spots on CNBC for ...
(Date:7/10/2014)... It is a great honor for Avery ... the world-renowned Thoracic and Cardiovascular surgeon, Mark E Ginsburg, ... Ginsburg, with over 34 years of experience, is currently ... Samaritan Regional Medical Center. Dr. Ginsburg has been implanting ... is considered an expert in the implantation of the ...
Breaking Biology News(10 mins):SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 3Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 2Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 3Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 4Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 5Avery Biomedical Devices, Inc. announces the appointment of Mark E Ginsburg, M.D. to its Board of Directors 2
... twice as often as men, but estrogen might not be ... of the preliminary findings in the lab of Florida State ... Medicine. He recently was awarded a five-year, $1.8 million grant ... sex differences in anxiety. His research team also is working ...
... drugs is a huge industry with an annual turnover of ... extremely serious. Half of the malaria medication sold there could ... UK have now developed a technique that could resolve the ... have a prototype ready. It will resemble a small briefcase, ...
... Lizards are an important indicator species for understanding ... a crucial index for evaluating species health, but lizards ... recurring problem of spontaneous tail loss when lizards are ... way of evaluating these lizards. Dr. Shai Meiri of ...
Cached Biology News:Why does anxiety target women more? FSU researcher awarded $1.8 million grant to find out 2Problem of fake medicines in developing countries could be solved 2Getting a tail up on conservation? 2
(Date:7/10/2014)... Burkina Faso (PRWEB) July 10, 2014 ... Faso, today have access to an additional family ... increase access to contraception at all levels of ... a lower-dose formulation of a widely used contraceptive—Pfizer’s ... system. , Burkina Faso is the first of ...
(Date:7/10/2014)... Unraveling life’s mysteries can intrigue, amaze, and ... purchased a DNA test to unravel the ... a lifetime of memories, sharing, and closeness. In fact, ... genuinely brought the family closer together. , Recently, ... history and prior to taking the genetic ancestry ...
(Date:7/10/2014)... July 10, 2014  Franciscan St. Anthony ... capnography for respiratory monitoring outside the operating ... leaders in embracing state-of-the-art patient safety technology. ... are breathing and can alert medical caregivers ... the amount of carbon dioxide the patient ...
(Date:7/10/2014)... Calif., July 10, 2014   Ceres, Inc . ... seed company, announced today financial results for the three ... on its business. Ceres reported that the ... product performance this growing season in Brazil, which concluded ... the company,s sorghum evaluation areas for part of the ...
Breaking Biology Technology:Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 2Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 3Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 4Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 5Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 6Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9
... a surge in demand for nanotech tools in the ... by a New York consulting firm that focuses on ... also projected that sales of nanotech tools could double ... nanotechnology focuses on remarkable applications ranging from computer displays ...
... Hiring talent is a serious business. Many companies maintain ... matching the right person with the right skills to ... dollars are routinely spent on all manner of testing ... thinking styles, psychologies and talents of potential hires. Countless ...
... ago, while attending a conference on equity capital, the ... more than a few snickers from the participants. ... along with the entrepreneur's personal funds is nothing to ... Entrepreneurship Monitor (GEM) report. , ,William D. Bygrave, ...
Cached Biology Technology:Corporate clients will dominate surge in nanotech tool demand, study projects 2Corporate clients will dominate surge in nanotech tool demand, study projects 3Hiring in the name of talent 2Hiring in the name of talent 3Hiring in the name of talent 4Family reunion? Don't forget your business plan 2Family reunion? Don't forget your business plan 3
The S. cerevisiae Hansen strains are the parental yeast strains from which the deletions were derived....
The Hybrid Hunter Yeast Two-Hybrid System uses the activation of reporter genes to indicate positive protein-protein interactions. Two reporters are used an auxotrophic marker and lacZ....
Tris-Hepes kit of BG-163 & BG-165 (order number BG-166)...
Incorporating the innovative InGaAs detection system the Cary 6000i is the worlds most advanced UV-Vis-NIR spectrophotometer delivering superior signal to noise performance and outstanding sensitivit...
Biology Products: