Navigation Links
UCSB scientists discover potential drug delivery system
Date:8/25/2009

(Santa Barbara, Calif.) Scientists at UC Santa Barbara have discovered a potential new drug delivery system. The finding is a biological mechanism for delivery of nanoparticles into tissue. The results are published in this week's Proceedings of the National Academy of Sciences.

"This work is important because when giving a drug to a patient, it circulates in the blood stream, but often doesn't get into the tissue," said senior author Erkki Ruoslahti, of the Burnham Institute for Medical Research at UCSB. "This is especially true with tumors.

"We believe this method will lead to better, more efficient delivery of drugs," he said. In this study, the scientists used prostate cancer cells as their target, but the method could apply to any type of cell.

The scientists developed a peptide, a small piece of protein that can carry "cargo" for delivery into the cell. The cargo could be a nanoparticle, or even a cell. Riding on the peptide, the cargo gets out of the blood vessel and penetrates the tissue.

The drug is located at one end of the peptide. At the other is the "C terminal," which has the "motif" an amino acid sequence including arginine or lysine, that causes the tissue penetration. This terminal has to be open, the researchers found. The strict requirement for the C terminal led the group to coin a new name, the "C-end rule," or CendR, pronounced "sender."

Ruoslahti explained that another exciting aspect of the study is the discovery that viruses appear to use this "CendR" system to get into cells. "It's a natural system," he said. "We're not quite clear what the exact function is, but viruses appear to take advantage of it."

Ongoing research in the Ruoslahti lab is understanding how viruses use this system, and then working to develop inhibitors to prevent viruses from entering the cell.


'/>"/>

Contact: Gail Gallessich
gail.g@ia.ucsb.edu
805-893-7220
University of California - Santa Barbara
Source:Eurekalert  

Page: 1

Related biology news :

1. Scientists shed new light on behavior of shark tweens and teenagers
2. Scientists discover new species of crustacean on Lanzarote
3. Scientists discover bioluminescent green bombers from the deep sea
4. Study: Young Arctic muskoxen better at keeping warm than scientists thought
5. Scientists help explain effects of ancient Chinese herbal formulas on heart health
6. Scientists link genetic glitches to common childhood cancer
7. Scientists take early steps toward mapping epigenetic variability
8. UOG scientists successfully compete for research grants
9. Canadian scientists identify gene that makes water striders glide across water
10. Scientists conduct shark survey off US East Coast
11. Scientists demonstrate importance of niche differences in biodiversity
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UCSB scientists discover potential drug delivery system
(Date:5/21/2015)... , May 21, 2015 ... "Thermal Imaging Market by Solutions (Hardware, Software, Services), by ... Automotive & others), by End-Users (Military & Defense ... by MarketsandMarkets, Thermal Imaging Market is expected to ... Million by 2020, at a Compound Annual Growth ...
(Date:5/19/2015)... -- Technology is rapidly advancing, outpacing enterprises, ability to secure ... and their management are soon to be rendered obsolete ... as those developed by the FIDO Alliance™. With the ... BYOD, COPE, IoT, and mobile payments, the interconnected online ... In response to the call for seamless, secure, ...
(Date:5/11/2015)... SAN JOSE, Calif. , May 11, 2015 ... leading developer of human interface solutions, today announced ... Senior Vice President and Chief Financial Officer, reporting ... Mr. Ali replaces Synaptics, current Chief Financial Officer, ... in December 2014. Mr. Ali ...
Breaking Biology News(10 mins):Thermal Imaging Market Worth $9,998.9 Million by 2020 2Thermal Imaging Market Worth $9,998.9 Million by 2020 3Thermal Imaging Market Worth $9,998.9 Million by 2020 4HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 2HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 3Synaptics Appoints Wajid Ali as Senior Vice President and Chief Financial Officer 2
... AWRE ), a leading technology innovator and supplier ... call to discuss the company,s operating results for the third ... Eastern Time. President and CEO Edmund Reiter and CFO Rick ... call is being webcast by Thomson and can be accessed ...
... slice it, watermelon has a lot going for it ... there,s more. Evidence from a pilot study led by food ... be an effective natural weapon against prehypertension, a precursor to ... its kind in humans. FSU Assistant Professor Arturo Figueroa and ...
... ,URBANA When you think about "wine country," Illinois may not ... big business on the prairie. There are 90 wineries licensed in ... wine grapes can bring as much as $8,000 in sales, though ... produce 90,000 gallons per year, while many produce 3,000 to 10,000 ...
Cached Biology News:Aware, Inc. Announces Q3'10 Earnings Conference Call 2Florida State study finds watermelon lowers blood pressure 2Florida State study finds watermelon lowers blood pressure 3Taming wild grapes for better wine 2Taming wild grapes for better wine 3
(Date:5/20/2015)... 2015  Select Medical Corporation ("Select") (NYSE: ... granted early termination of the waiting period under ... as amended, applicable to the acquisition of Concentra ... venture that Select has created with Welsh, Carson, ... announced, MJ Acquisition Corporation has signed a definitive ...
(Date:5/20/2015)... Agricultural firm H.J. Baker & Bro., ... of Tiger-Sul. Since the purchase of Tiger Industries ... May 2005, H.J. Baker has leveraged the innovation of ... comprehensive portfolio of product offerings and solutions expertise. The ... the innovation of Tiger-Sul, transforming the company into a ...
(Date:5/20/2015)... DIEGO , May 20, 2015  Cypher ... announced a collaboration with Celgene Corporation to apply ... genomic biomarkers that associate with patient response to ... is intended to help accelerate patient access to ... efficiencies in clinical research and development and potentially ...
(Date:5/20/2015)... RESEARCH TRIANGLE PARK, North Carolina ... das weltweit führende Unternehmen für klinische ... geprüften Finanzergebnisse für das Geschäftsjahr 2014, ... abgeschlossen und eingereicht. Das Unternehmen hat ... abgeschlossen. Logo - ...
Breaking Biology Technology:Select Medical Corporation's Proposed Acquisition of Concentra Inc. through Joint Venture with Welsh Carson Receives Antitrust Clearance 2Agricultural Firm H.J. Baker & Bro., Inc., Celebrates 10 Years Since Acquisition Of Tiger-Sul 2Agricultural Firm H.J. Baker & Bro., Inc., Celebrates 10 Years Since Acquisition Of Tiger-Sul 3Cypher Genomics Collaborates with Celgene Corporation to Identify Novel Genomic Biomarkers 2Marken schließt Ergebnisse für das Geschäftsjahr 2014 ab 2
... , SAN DIEGO, Dec. 10 Biomatrica, the ... release of SampleWare 3.1 software system for laboratory inventory, organization ... an audit trail functionality that tracks user and date stamps ... , The addition of the audit trail feature offers ...
... ... center in the country specifically established to treat adolescents and adults and is today the ... in its registry. , ... December 10, 2009 -- The Hertz Family Foundation of Santa Monica has announced that total ...
... Opinion Leaders Examine the Role ... Dec. 9 On Tuesday, December 8, 2009, Scientific American , the ... Decade-2 Education Forum in Washington, D.C. The forum was ... was sponsored by Amgen , a leading biotechnology company committed to science ...
Cached Biology Technology:Biomatrica Launches SampleWare 3.1 2Biomatrica Launches SampleWare 3.1 3Hertz Annual Appeal for Adult Congenital Heart Disease Center At UCLA Passes $2-Million Mark in Funds Raised Over Ten Years 2Hertz Annual Appeal for Adult Congenital Heart Disease Center At UCLA Passes $2-Million Mark in Funds Raised Over Ten Years 3Science Education Experts Discuss Solutions for Global Competitiveness at Scientific American Forum 2Science Education Experts Discuss Solutions for Global Competitiveness at Scientific American Forum 3
... reliable and compact GC-8A is Shimadzu's basic ... and simple to use, the GC-8A supports ... control, on column injection port(s), and analog ... models are available. The GC-8A is only ...
... system combines world-class performance hardware, Cerity Networked ... world-renowned support and columns, as well as ... that lets you reach uncompromising results and ... data. The Agilent 6820 GC system is ...
... Adding an exciting new chapter ... GC leadership, Agilents 7890A GC ... to take your lab to ... and GC/MS performance, including advanced ...
The essence of fluorescence analysis is sensitivity. The high throughput optical system in the RF-5301PC employs a blazed holographic grating, photomultiplier and digital signal processing to provide...
Biology Products: