Navigation Links
UCSB scientists discover potential drug delivery system

(Santa Barbara, Calif.) Scientists at UC Santa Barbara have discovered a potential new drug delivery system. The finding is a biological mechanism for delivery of nanoparticles into tissue. The results are published in this week's Proceedings of the National Academy of Sciences.

"This work is important because when giving a drug to a patient, it circulates in the blood stream, but often doesn't get into the tissue," said senior author Erkki Ruoslahti, of the Burnham Institute for Medical Research at UCSB. "This is especially true with tumors.

"We believe this method will lead to better, more efficient delivery of drugs," he said. In this study, the scientists used prostate cancer cells as their target, but the method could apply to any type of cell.

The scientists developed a peptide, a small piece of protein that can carry "cargo" for delivery into the cell. The cargo could be a nanoparticle, or even a cell. Riding on the peptide, the cargo gets out of the blood vessel and penetrates the tissue.

The drug is located at one end of the peptide. At the other is the "C terminal," which has the "motif" an amino acid sequence including arginine or lysine, that causes the tissue penetration. This terminal has to be open, the researchers found. The strict requirement for the C terminal led the group to coin a new name, the "C-end rule," or CendR, pronounced "sender."

Ruoslahti explained that another exciting aspect of the study is the discovery that viruses appear to use this "CendR" system to get into cells. "It's a natural system," he said. "We're not quite clear what the exact function is, but viruses appear to take advantage of it."

Ongoing research in the Ruoslahti lab is understanding how viruses use this system, and then working to develop inhibitors to prevent viruses from entering the cell.


Contact: Gail Gallessich
University of California - Santa Barbara

Page: 1

Related biology news :

1. Scientists shed new light on behavior of shark tweens and teenagers
2. Scientists discover new species of crustacean on Lanzarote
3. Scientists discover bioluminescent green bombers from the deep sea
4. Study: Young Arctic muskoxen better at keeping warm than scientists thought
5. Scientists help explain effects of ancient Chinese herbal formulas on heart health
6. Scientists link genetic glitches to common childhood cancer
7. Scientists take early steps toward mapping epigenetic variability
8. UOG scientists successfully compete for research grants
9. Canadian scientists identify gene that makes water striders glide across water
10. Scientists conduct shark survey off US East Coast
11. Scientists demonstrate importance of niche differences in biodiversity
Post Your Comments:
Related Image:
UCSB scientists discover potential drug delivery system
(Date:10/29/2015)... Oct. 29, 2015  Rubicon Genomics, Inc., today ... distribution of its DNA library preparation products, including ... new ThruPLEX Plasma-seq kit. ThruPLEX Plasma-seq has been ... of NGS libraries for liquid biopsies--the analysis of ... prognostic applications in cancer and other conditions. Eurofins ...
(Date:10/27/2015)... 27, 2015 Munich, Germany ... Mapping technology (ASGM) automatically maps data from mobile eye ... , so that they can be quantitatively analyzed ... Munich, Germany , October 28-29, 2015. SMI,s ... from mobile eye tracking videos created with SMI,s ...
(Date:10/23/2015)... DUBLIN , Oct. 23, 2015 Research ... of the "Global Voice Recognition Biometrics Market 2015-2019" ... --> --> The global voice recognition ... during 2014-2019. --> ... 2015-2019, has been prepared based on an in-depth market ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... (PRWEB) , ... November 24, 2015 , ... ... maintain healthy metabolism. But unless it is bound to proteins, copper is also ... Health (NIH), researchers at Worcester Polytechnic Institute (WPI) will conduct a systematic study ...
(Date:11/24/2015)... , Nov. 24, 2015  Clintrax Global, Inc., a worldwide ... Carolina , today announced that the company has set a ... a 391% quarter on quarter growth posted for Q3 of 2014 ... and Mexico , with the establishment of ... December 2015. --> United Kingdom and ...
(Date:11/24/2015)... ... November 24, 2015 , ... The Academy of Model ... Group (SIG), MultiGP, also known as Multirotor Grand Prix, to represent the First–Person View ... years. Many AMA members have embraced this type of racing and several new model ...
(Date:11/24/2015)... Israel , Nov. 24, 2015  Tikcro Technologies Ltd. (OTCQB: TIKRF) ... on December 29, 2015 at 11:00 a.m. Israel ... Electra Tower, 98 Yigal Allon Street, 36 th Floor, ... of Eric Paneth and Izhak Tamir to the ... Rami Skaliter as external directors; , approval of an amendment to ...
Breaking Biology Technology: