Navigation Links
UCSB scientists discover inner workings of potent cancer drug
Date:10/14/2010

(Santa Barbara, Calif.) A potent drug derived from an evergreen tree may soon save the lives of some patients with the deadliest form of breast cancer. According to the National Cancer Institute, breast cancer will claim approximately 40,000 lives in the U.S. this year.

Scientists at UC Santa Barbara, in cooperation with scientists in the pharmaceutical industry, have discovered the mechanism by which this drug kills cancer cells. The team has isolated the drug's action in the test tube as well as in cancer cells.

The results are reported in two studies published as the cover story of the October issue of Molecular Cancer Therapeutics, authored by a team of UCSB researchers. The articles feature work performed in the laboratories of Mary Ann Jordan and Leslie Wilson, professors in UCSB's Department of Cellular, Molecular and Developmental Biology.

"This anticancer drug, called maytansine, when linked to a tumor-targeting antibody, shows promising early results in clinical trials on patients with metastatic breast cancer," said Jordan. "Although the drug is not yet approved by the FDA, current clinical trials are open to new patients. And, the drug is being tested, with good results, on other cancers, such as multiple myeloma and B-cell lymphoma."

Early clinical trials show that the drug shrank the tumors of one-third of the patients in the breast cancer study a strong result, according to the authors. The studies explain that the drug works by targeting the microtubules of cancer cells. Microtubules are the dynamic, rapidly growing and shortening protein filaments that help cells to divide and multiply.

"We discovered how the drug is taken up into the tumor cells," said Jordan. "We found out that it is metabolized by the cancer cells, inhibits the dynamics of cellular microtubules, and thus blocks the mitosis of the spindles in the cells, causing them to die."

Manu Lopus, a postdoctoral fellow a
'/>"/>

Contact: Gail Gallessich
gail.g@ia.ucsb.edu
805-893-7220
University of California -- Santa Barbara
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
2. Scientists identify novel inhibitor of human microRNA
3. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
4. MU scientists go green with gold, distribute environmentally friendly nanoparticles
5. Scientists identify gene that may contribute to improved rice yield
6. Scientists discover why a mothers high-fat diet contributes to obesity in her children
7. MU scientists see how HIV matures into an infection
8. Earth scientists keep an eye on Texas
9. Thinking it through: Scientists call for policy to guide biofuels industry toward sustainability
10. Scientists identify a molecule that coordinates the movement of cells
11. Scientists Find new migratory patterns for Mediterranean and Western Atlantic bluefin tuna
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UCSB scientists discover inner workings of potent cancer drug
(Date:12/17/2014)... , Dec. 15, 2014  HITLAB SM ... Clinical Practices (GCP) audit to confirm its adherence ... regulations. This accomplishment enables HITLAB to conduct regulated ... the highest principles for patient safety and research ... global healthcare access, quality, and delivery with innovative ...
(Date:12/15/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/87pph8/global_facial ) ... Facial Recognition Market 2015-2019" report to their ... Facial recognition is a technology used ... measures the overall facial feature of a person ... distance between eyes. Facial recognition is used for ...
(Date:12/11/2014)... 10, 2014  Data Sciences International (DSI), the ... a new series of digital telemetry implants to ... M series, part of the PhysioTel™ Digital platform, ... possible physiologic data when incorporating functional endpoints into ... to toxicology studies has evolved from short ECG ...
Breaking Biology News(10 mins):HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3New telemetry implants expected to change how large animal toxicology studies are conducted 2
... the October 2011 issue of Experimental Biology and ... Medical Center led by Stephen Tsang, MD, Ph.D have ... model for retinitis pigmentosa (RP) using novel bipartite gene ... by progressive degeneration of rod photoreceptors (which mediate night ...
... Advances in tissue engineering and stem cell therapies ... National Institutes of Health,s fourth Symposium on Cardiovascular Regenerative ... 30 leading researchers will share insights into the state ... sponsored by the NIH,s National Heart, Lung, and Blood ...
... Karolinska Institutet have discovered a new inherited disorder that ... adenosine kinase deficiency, is caused by mutations in the ... The findings, which are presented in the ... possible through the detailed biochemical examination of a Swedish ...
Cached Biology News:Cell-specific mechanism-based gene therapy approach to treat retinitis pigmentosa 2Cell-specific mechanism-based gene therapy approach to treat retinitis pigmentosa 3NIH hosts Cardiovascular Regenerative Medicine Symposium Oct. 4-5 2New inherited neurometabolic disorder discovered 2
(Date:12/24/2014)... St. Louis, Missouri (PRWEB) December 23, 2014 ... and targeting Swiss biotechnology company, Syngenta, are in the ... for pretrial proceedings. The consolidated case is In Re: ... in the U.S. District Court for the District of ... litigation (MDL) has been handed over to U.S. District ...
(Date:12/24/2014)... Texas (PRWEB) December 23, 2014 ... methyl mercaptan such as its definition, classification, ... presents product specification, manufacturing process, and product ... technology and applications. The analysis also covers ... marketing channels, industry development trend and proposals. ...
(Date:12/24/2014)... Texas , Dec. 23, 2014 ... company focused on gynecologic disease, announced today that ... Schuler , Birchview Fund LLC and several Vermillion ... of unregistered shares of Vermillion,s common stock and ... stock in a private placement.  ...
(Date:12/22/2014)... The Center for Professional Innovation ... training across the life sciences industry, has partnered with ... to provide the organization's members with discounted classroom courses, ... the more than 350 sessions across 80 course titles. ... when registering for a public course at ...
Breaking Biology Technology:Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2Worldwide Methyl Mercaptan Market 2015-2020 Forecasts on Development & Trends Now Available at ReportsnReports.com 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 4Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 5CfPIE Announces Partnership with the Society for Clinical Data Management 2CfPIE Announces Partnership with the Society for Clinical Data Management 3
... concerned and troubled about the editorial titled, "End ... last week's Wisconsin State Journal (08/07/03). Wisconsin is only ... this channel of distribution and growing industry. The notion ... just plain bad business. We need to encourage the ...
... Now Largest Venture Capital Firm Based in Wisconsin ... raised and closed an additional round of fund raising ... to support applied technology, life sciences, healthcare and business ... and the Midwest. Milwaukees Baird Venture Partners was picked ...
... Wisconsin Technology Network recently interviewed two University of Wisconsin-Madison researchers ... principles behind learning a game can be used in academics. ... James Gee, Ph.D. , is a professor of Curriculum and ... the author of What Video Games Have to Teach Us ...
Cached Biology Technology:Is Wisconsin a Technology Leader or Laggard? 2Milwaukee Company Raises $90 million VC Fund for Midwest Projects 2Milwaukee Company Raises $90 million VC Fund for Midwest Projects 3The Learning Game - Researchers Study Video Gaming Principles that Apply to Education 2The Learning Game - Researchers Study Video Gaming Principles that Apply to Education 3The Learning Game - Researchers Study Video Gaming Principles that Apply to Education 4The Learning Game - Researchers Study Video Gaming Principles that Apply to Education 5The Learning Game - Researchers Study Video Gaming Principles that Apply to Education 6